Cytotoxic Compounds from the DeepSea Sediment-Derived Streptomyces malaysiensis OUCMDZ-2167

Critical Secondary Metabolites Confer the Broad-Spectrum Pathogenic Fungi Resistance Property of a Marine-Originating Streptomyces sp. HNBCa1

“…Interestingly, in pepper, HNBCa1 could strongly inhibit the mycelia growth of three pathogenic fungi, including HNBY03, HNBY04, and HNBY14 that lead to leaf spot disease, phytophthora blight, and anthracnose, respectively (Figure d). Some species of Streptomyces from sponges also showed good antibacterial activity, , but the antibacterial spectrum of them was not as broad as that of HNBCa1.…”

New Natural Products ofStreptomycesSourced from Deep-Sea, Desert, Volcanic, and Polar Regions from 2009 to 2020

“…aureus ATCC 29213/MRSE Shhs-E1: 12.5～32.0 µg/mL 3536 South China Sea [64] Bafilomycins B1/C1 (64/65) NA4 Inhibitory activities against Fusarium spp. and R. solani 1464 South China Sea [65] Marformycins A～F (66～71) SCSIO 10141 M. luteus: 0.06～4.0 μg/mL 1396 South China Sea [66] Marangucyclines 2403 South China Sea [67] 74/75 PKU-MA01297 -3202 Indian Ocean [68] 76 SCSIO 04496 -3536 South China Sea [77] Tunicamycin [69] Atratumycin (78) SCSIO ZH16 M. tuberculosis H37Ra/H37Rv: 3.8/ 14.6 µmol•L -1 3536 South China Sea [61] 79/80 OUCMBZ-4112 -2206 South China Sea [62] 81 OUCMDZ-2167 -2061 South China Sea [63] Butenolids 1/2 (82/83) TP-A0873 Peroxisome proliferator activated receptor-PPARα agonists NA Toyama Bay [78] Ahpatinins Ac/Pr (84/85) ACT232 Aspartic protease inhibitors: 0.01～0.05 µmol•L -1 1174 Sagami Bay [64] Fradiamines A/B (86/87) MM456M-F7 Clostridium difficile: 8～32 μg/mL 806 Sagami Bay [71] 88～90 M-157 HepG2: 51.5 µmol•L -1 2000 Cantabrian Sea [72] Anthracimycin B (91) M-169…”

“…鞠建华等从中国南海沉积物中分离的链霉菌 SCSIO ZJ46、NA4、SCSIO 10141、SCSIO 11594、SCSIO 04496、SCSIO S15077 或 SCSIO ZH16 中, 分别获得 Desotamides B～D (61～63)、 Bafilomycins B1～C1 (64～ 65)、Marformycins A～F (66～71)、Marangucyclines A～ B (72～73)、二酮哌嗪化合物( 76)、Tunicamycin E (77)、 Atratumycin (78)等多类新天然产物. 朱伟明等从中国南 海深海来源的链霉菌 OUCMBZ-4112、OUCMDZ-2167 中分离到了两个新的吡咯生物碱(79～80) [62] 和 1 个新的 呋喃衍生物(81) [63] .…”

New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

“…As part of our studies to search for new bioactive NPs from deep-sea-derived bacteria [ 33 , 34 , 35 ], we found that the extract of the fermentation broth of a deep-sea (2000 m) water-derived Ochrobactrum sp. OUCMDZ-2164 showed cytotoxic effect on the A549 (83% inhibition) and K562 (70% inhibition) cell line at 0.1 mg/mL.…”

“…Compound 1 showed selective cytotoxicity against human lung carcinoma cell line (A549) and human leukemia cell line (K562) with IC 50 values of 15 and 23 μM, respectively. This is the second example of ansamycins from the deep sea-derived bacteria [ 33 ].…”