2016
DOI: 10.3390/md14050082
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Cytotoxic Compounds from the Saudi Red Sea Sponge Xestospongia testudinaria

Abstract: Bioassay-guided fractionation of the organic extract of the Red Sea sponge Xestospongia testudinaria led to the isolation of 13 compounds including two new sterol esters, xestosterol palmitate (2) and xestosterol ester of l6′-bromo-(7′E,11′E,l5′E)-hexadeca-7′,11′,l5′-triene-5′,13′-diynoic acid (4), together with eleven known compounds: xestosterol (1), xestosterol ester of 18′-bromooctadeca-7′E,9′E-diene-7′,15′-diynoic acid (3), and the brominated acetylenic fatty acid derivatives, (5E,11E,15E,19E)-20-bromoeic… Show more

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Cited by 19 publications
(17 citation statements)
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“…The anticancer activity (IC 50 = 2.273 ppm) of X. testudinaria sponge toxic isolate agreed with to a previous report [18], in which the IC 50 of ethanol extract of X. testudinaria sponge on HeLa, HepG-2, and Daoy cells was 83.35, 23.45, and 23.31 ppm, respectively. In addition, the n-EH from the same sponge had IC 50 values of 33.7, 30.2, and 20.74 ppm in of on HeLa, HepG-2, and Daoy cells, respectively.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…The anticancer activity (IC 50 = 2.273 ppm) of X. testudinaria sponge toxic isolate agreed with to a previous report [18], in which the IC 50 of ethanol extract of X. testudinaria sponge on HeLa, HepG-2, and Daoy cells was 83.35, 23.45, and 23.31 ppm, respectively. In addition, the n-EH from the same sponge had IC 50 values of 33.7, 30.2, and 20.74 ppm in of on HeLa, HepG-2, and Daoy cells, respectively.…”
Section: Discussionsupporting
confidence: 91%
“…Few studies have assessed the anticancer activity of Xestospongia testudinaria sponge. The alcohol and n-hexane extracts (EH) from X. testudinaria from the Saudi Red Sea were found to have strong cytotoxic activity against human cervical cancer (HeLa), human hepatocellular carcinoma (HepG-2), and human medulloblastoma (Daoy) cell lines [18]. The methanol extract of X. testudinaria sponge from Sanur, Bali, Indonesia had anticancer activity against HeLa cells with an IC 50 value of 1327 ppm [19].…”
Section: Introductionmentioning
confidence: 99%
“…465) from a Myrmekioderma sponge and four reports of sterols and sterol esters 985-1000 (ref. [466][467][468][469] were made from Xestospongia and Topsentia sponges in 2016; compounds 994 and 995 had been synthesised previously. 470,471 Only two triterpenoid structures were published in 2016, one 1001 from Jaspis stellifera, 472 and the other 1002 from a Lipastrotethya sp.…”
Section: Spongesmentioning
confidence: 99%
“…The tested compounds were solubilized in dimethyl sulfoxide (DMSO) and stored at −20 °C. A 0.5% solution of crystal violet was prepared in MeOH and used to stain the viable cells [ 40 , 41 , 42 , 43 ]. Notably, crystal violet binds to proteins and DNA in adherent and viable cells, so this staining is indicative of the viability of the treated cells.…”
Section: Methodsmentioning
confidence: 99%