Cytotoxic Effect of Alkaloid Extract of Equisetum arvense Plant on Human lymphocytes and MCF7 Cancer Cell Line

Ahmed, Abeer Habeb; Mohammed, Ibrahim H.; Tawfeeq, Amer T.

doi:10.24237/djps.15.02.479c

Cited by 3 publications

(2 citation statements)

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“…Convolvulus arvensis showed anticancer effect against human tumor cell line (Hela), lymphoblastic leukemia, Jurkat cells, human Rhabdomyosarcoma(RD) tumor cell line and 7-12-dimethyl benz(a)antheracene (DMBA) induced skin carcinogenesis (201)(202)(203)(204)(205) . Convolvulus scammonia was active against mice implanted with hepatic cancer cells (hepatic cell H22) and CHO cell line (206)(207)(208) . Epidermal carcinoma of nasopharynx cells, human breast cancer cell lines (MDA-MB-231 and MCF-7), melanoma cells (B16F10, SK-MEL-28, and A375), leukemic cell lines U937, HL-60 and myelogenous leukemia cell line K562 (209)(210)(211)(212)(213)(214) .…”

Section: Plants With Anticancer Effectsmentioning

confidence: 99%

Natural sources as promising future anticancer therapies - A review

Thuwaini¹

2022

GSC Biol. and Pharm. Sci.

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Section: Plants With Anticancer Effectsmentioning

confidence: 99%

Natural sources as promising future anticancer therapies - A review

Thuwaini¹

2022

GSC Biol. and Pharm. Sci.

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“…The majority of anticancer drugs used at this time in clinical settings are described to induce cell death by apoptosis (7). In previous research, the ability of E. arvense alkaloid extract to inhibit the proliferation of the MCF7 cell line was approved (9). In this research the alkaloid extract of Equisetum arvense was used to detect its capacity to induce…”

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confidence: 99%

Alkaloid Extract of Equisetum arvense Plant Induce Apoptosis in MCF7 Cancer Cell Line

Abeer H. Ahmed,

Amer T. Tawfeeq,

Ibrahim H. Mohammed

2020

IJCMG

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This study was conducted to detect the ability of an alkaloid extracted from Equisetum arvense to induce apoptosis on MCF7 cancer cells. The IC50 concentration was employed in these experiments (325 μg/ml at 24hr), it was obtained from studying the effect of the alkaloid extract on the growth inhibition of cancer cells after 24 hours of exposure. genes involved in apoptosis (P53, BAX, Caspase8, and Caspase9) were assessed on the mRNA level.besides that, a study for the cells morphological changes that occurred via apoptosis was carried out by staining with a mixture of two fluorescence dyes acridine orange and propidium iodide. Mitochondrial membrane potential was also assessed. The results showed that the expression level of apoptosis genes was elevated. Apoptosis like morphological changes was noticed in cellular membranes and nucleus. Apoptosis characterization of the mitochondria membrane was detected as well. These results revealed the capability of this alkaloid extract to induce apoptosis in this breast cancer cell line. This study confirmed the substantial cytotoxic and pro-apoptotic activity of Equisetum arvense alkaloid extract toward the studied cell line, which indicates the utility of this substance in anticancer therapy.

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