Cytotoxic effect of Argentine medicinal plant extracts on human hepatocellular carcinoma cell line

Ruffa, María Julieta; Ferraro, Graciela; Wagner, Marcelo L.; Calcagno, María de Luján; Campos, Rodolfo Héctor; Cavallaro, Lorenzo

doi:10.1016/s0378-8741(01)00400-7

Cited by 172 publications

(114 citation statements)

References 17 publications

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“…have an antiproliferative effect. Thus, it was described that A. triangularis inhibited strongly the proliferation of human epidermoid carcinoma (Mongelli et al, 2000), and A. macroura Gomez showed cytotoxic effect against a human hepatocellular carcinoma (Ruffa et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Chaouki

Léger

Eljastimi³

et al. 2010

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

“…In this study we have explored four different polarity extracts from each of those plants on the human breast cancer cell line MCF-7, in order to confirm or discourage their popular use. (Hmamouchi, 1999;Hmamouchi et al, 2000;Merzouki et al, 2000;Ruffa et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Chaouki

Léger

Eljastimi³

et al. 2010

Pharmaceutical Biology

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“…It is popularly used in the form of alcoholic extracts, decoctions and infusions for the treatment of cough, bronchitis, arthritis, diseases of the digestive system and as diuretic, tranquilizer, haemostatic and tonic agent. It also possess antimicrobial, antiviral, cytotoxic and immunomodulatory activities (8,11,13,15). Nevertheless it can cause allergic sensitivity, skin disease, fever and visual problems in sensitive individuals.…”

Section: Introductionmentioning

confidence: 99%

Essential oil of Lithraea molleoides (Vell.): chemical composition and antimicrobial activity

Shimizu¹,

Bueno²,

Rodrigues³

et al. 2006

Braz. J. Microbiol.

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Lithraea molleoides (Vell.) (Anacardiaceae) is a tree found in Brazil, Paraguay, Bolivia, Uruguay, Argentina and Chile. It is popularly used in the form of alcoholic extracts, decoctions and infusions for the treatment of cough, bronchitis, arthritis, diseases of the digestive system and as diuretic, tranquilizer, haemostatic and tonic agent. The objectives of this study were the extraction of the essential oil of the mature fruit, leaves and aerial parts of the plant and quantification of the yield thereof; the identification and quantification of the principal components of the essential oil and the determination of its antimicrobial activity against bacteria and yeast. The essential oil yield of the mature fruits was 1.0% but essential oil was not detected in leaves and flowery branches. The gas chromatograph-mass spectrometer (GC-MS) analysis of the essential oil of the mature fruits detected the presence of limonene (89.89%), α-pinene (3.48%), β-pinene (2.63%), α-terpineol (1.27%), myrcene (0.64%), sabinene hydrate (0.54%), 4-terpineol (0.28%), camphene (0.22%) and Δ-3-carene (0.13%). The essential oil was active against just a few of the Gram-positive bacteria and yeast tested and did not present antimicrobial activity against Gram-negative bacteria.

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“…E-mail: gagliard@uerj.br. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License (Ponte et al, 1996), acaricide (Johnson et al, 1997), antibacterial (Szczepan et al, 1972;Williams et al, 2003), antifungal (Benevides et al, 2001), and treatment for bovine viral diarrhea virus (BVDV) (Ruffa et al, 2002). Many of these effects may result from a cytotoxic mechanism also described for this species as the inhibition of antioxidant status in vitro and in vivo, featuring pro-oxidant effects in a concentrationdependent manner (Andrade et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, components of the extracts have shown a well-defined antioxidant activity (Delle-Monache et al, 1996;Okada et al, 2008), as well as immunomodulatory (Quadros et al, 1999) and neuropharmacological activities (Cifuentes et al, 2001). Research in the last two decades focused on polysulfides with antineoplastic action produced in this species (MataGreenwood et al, 2001;Rosner et al, 2001;Ruffa et al, 2002;Williams et al, 2003;Williams et al, 2007;Webster et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of extracts from field and in vitro plants of Petiveria alliacea L. on plasmidial DNA

N¹,

Mansur²,

Dantas³

et al. 2014

J. Med. Plants Res.

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Petiveria alliacea L. is a native herbaceous species from the Amazon region traditionally used in folk medicine for its various pharmacological activities. This study aimed to perform a comparative assessment of genotoxic and antigenotoxic potential of field-and in vitro-grown plants. Specimens from different populations from Rio de Janeiro State were used as donor plants for in vitro culture on Murashige and Skoog (MS) medium. Aqueous extracts from field and in vitro plants were evaluated by analyzing their effect on the integrity of pUC 9.1 plasmid. DNA genotoxic potential was assessed after treatment of plasmid DNA with increasing concentrations of aqueous extracts (1.0, 5.0 t o 10.0 mg/ml) from the populations studied and the in vitro plants originated from them. The electrophoretic analysis showed changes in the structural conformation of plasmid DNA, indicating the occurrence of single-and double-strand breaks caused by the extracts, demonstrating the genotoxic potential at higher concentrations. The antigenotoxic potential was assessed based on plasmid protection induced by the extracts after DNA treatment with stannous chloride. Thus, data also pointed to a antigenotoxic effect of extracts against oxidative damage. In addition, the intensity of the effect of extracts on plasmid DNA varied according to origin of plants.

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Cytotoxic effect of Argentine medicinal plant extracts on human hepatocellular carcinoma cell line

Cited by 172 publications

References 17 publications

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Essential oil of Lithraea molleoides (Vell.): chemical composition and antimicrobial activity

Effect of extracts from field and in vitro plants of Petiveria alliacea L. on plasmidial DNA

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