Cytotoxic effect of elements released clinically from gold and CAD-CAM fabricated ceramic crowns

Elshahawy, Waleed; Shohieb, F.; Yehia, Hossam M.; Etman, Wedad M; Watanabe, Ikuya; Kramer, Phillip R.

doi:10.1016/j.tdj.2014.10.002

Cited by 7 publications

(8 citation statements)

References 15 publications

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“…Biocompatibility refers to a material’s ability to not affect the local or systemic behaviour of an organism. Cytotoxicity is an important biocompatibility component [11,53]. It can be studied in in vivo or in vitro studies.…”

Section: Discussionmentioning

confidence: 99%

“…Once implant osseointegration is achieved, a transepitelial abutment is placed for the soft tissue remodelling process [1]. The abutment material should be as similar as possible to the natural tissues in order to create a hermetic barrier [2] between the gingiva and abutment to achieve cellular proliferation and protect the underlying implant These materials must be biocompatible [2,3,4,5,6,7,8,9,10] because dental materials are always in contact with soft or bone tissue [6,11].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility of Polymer and Ceramic CAD/CAM Materials with Human Gingival Fibroblasts (HGFs)

et al. 2019

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Four polymer and ceramic computer-aided design/computer-aided manufacturing (CAD/CAM) materials from different manufacturers (VITA CAD-Temp (polymethyl methacrylate, PMMA), Celtra Duo (zirconia-reinforced lithium silicate ceramic, ZLS), IPS e.max CAD (lithium disilicate (LS2)), and VITA YZ (yttrium-tetragonal zirconia polycrystal, Y-TZP)) were tested to evaluate the cytotoxic effects and collagen type I secretions on human gingival fibroblasts (HGFs). A total of 160 disc-shaped samples (Ø: 10 ± 2 mm; h: 2 mm) were milled from commercial blanks and blocks. Direct-contact cytotoxicity assays were evaluated at 24, 48, and 72 h, and collagen type I (COL1) secretions were analysed by cell-based ELISA at 24 and 72 h. Both experiments revealed statistically significant differences (p < 0.05). At 24 and 48 h of contact, cytotoxic potential was observed for all materials. Later, at 72 h, all groups reached biologically acceptable levels. LS2 showed the best results regarding cell viability and collagen secretion in all of the time evaluations, while Y-TZP and ZLS revealed intermediate results, and PMMA exhibited the lowest values in both experiments. At 72 h, all groups showed sharp decreases in COL1 secretion regarding the 24-h values. According to the results obtained and the limitations of the present in vitro study, it may be concluded that the ceramic materials revealed a better cell response than the polymers. Nevertheless, further studies are needed to consolidate these findings and thus extrapolate the results into clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatibility of Polymer and Ceramic CAD/CAM Materials with Human Gingival Fibroblasts (HGFs)

et al. 2019

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confidence: 98%

“…Rau et al reported that the chemical resistance and corrosion rate of magnesium alloy were improved with the application of a glass-ceramic coating [26].Chemical durability is also important because leached ions during corrosion may not be safe. The literature demonstrated the cytotoxicity of materials in ceramic [27][28][29][30]. Elshahawy et al reported that Zn had the highest cytotoxicity (60% cell viability) to fibroblast cells among the ions released from gold alloys and ceramic crowns in patients' saliva, followed by Cu > Ag > Pd > Al > Au > Si.…”

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confidence: 99%

“…The cytotoxicity was not related to the amount of the ion released in this study; Si had the highest released amount, but the least cytotoxicity (90% cell viability). This indicates Si has higher biocompatibility [28].Another study analyzed the medium where all-ceramic and provisional materials were immersed and found the materials leached to be slightly cytotoxic [30].Research has shown that silicon carbide (SiC) is a promising ceramic material for biomedical applications [31][32][33]. This material has superior properties including lightweight, high strength, corrosion resistance, and high temperature resistance [31][32][33][34][35][36][37][38][39][40][41].…”

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confidence: 99%

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Novel Coating to Minimize Corrosion of Glass-Ceramics for Dental Applications

et al. 2020

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The effect of a novel silicon carbide (SiC) coating on the chemical durability of a fluorapatite glass-ceramic veneer was investigated by examining weight loss and ion release levels. The hypothesis that this novel coating will exhibit significant corrosion resistance was tested. Inductively coupled plasma atomic emission spectrometer (ICP) was used for ion concentration determination and scanning electron microscopy (SEM) for surface morphology analyses. Samples were immersed in pH 10 and pH 2 buffer solutions to represent extreme conditions in the oral cavity. Analyses were done at 15 and 30 days. The SiC coated group demonstrated significant reduction in weight loss across all solutions and time points (p < 0.0001). Ion release analyses demonstrated either a marginally lower or a significantly lower release of ions for the SiC-coated disks. SEM analysis reveals planarization of surfaces by the SiC-coated group. The surfaces of coated samples were not as corroded as the non-coated samples, which is indicative of the protective nature of these coatings. In conclusion, SiC is a novel coating that holds promise for improving the performance of ceramic materials used for dental applications.Materials 2020, 13, 1215 2 of 11 substances pH 8-14 (e.g., spinach, soybeans, and antacids) [1]. Eventually, this constant change in pH can decrease the fracture strength of glass-ceramics [13,14] and increase surface roughness [15,16]. This roughening of the restoration can lead to plaque accumulation and increased wear of the opposing enamel [17,18]. Dental restorations should be able to withstand these fluctuations in pH.Chemical durability of dental materials has been extensively studied because of the importance of this property on the longevity of the restoration. Intrinsic or extrinsic modifications can be used to improve chemical durability. Several studies have demonstrated chemical stability for glass-ceramics can be enhanced by (1) different ratio of compositions; (2) addition of oxides, such as CaO, K 2 O, and Al 2 O 3 ; and (3) fluorine and calcium phosphates as part of intrinsic modifications [19-23]. Extrinsic modification can be achieved by producing additional layers on the surface to enhance chemical durability and other physical properties [24-26]. Esquivel-Upshaw et al. showed that glazed material has better chemical resistance than non-glazed material [1]. Topateş et al. discussed the effect of different glaze compositions on chemical durability [25]. Rau et al. reported that the chemical resistance and corrosion rate of magnesium alloy were improved with the application of a glass-ceramic coating [26].Chemical durability is also important because leached ions during corrosion may not be safe. The literature demonstrated the cytotoxicity of materials in ceramic [27][28][29][30]. Elshahawy et al. reported that Zn had the highest cytotoxicity (60% cell viability) to fibroblast cells among the ions released from gold alloys and ceramic crowns in patients' saliva, followed by Cu > Ag > Pd > Al > Au > Si. The cyt...

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TiN nanoparticles: synthesis and application as near-infrared photothermal agents for cancer therapy

Jiang

Wei

et al. 2019

J Mater Sci

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Cytotoxic effect of elements released clinically from gold and CAD-CAM fabricated ceramic crowns

Cited by 7 publications

References 15 publications

Biocompatibility of Polymer and Ceramic CAD/CAM Materials with Human Gingival Fibroblasts (HGFs)

Biocompatibility of Polymer and Ceramic CAD/CAM Materials with Human Gingival Fibroblasts (HGFs)

Novel Coating to Minimize Corrosion of Glass-Ceramics for Dental Applications

TiN nanoparticles: synthesis and application as near-infrared photothermal agents for cancer therapy

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