Cytotoxic effect of functionalized superparamagnetic samarium doped iron oxide nanoparticles for hyperthermia application

Hemalatha, K.; Alamelumangai, K; Arulmozhi, R.; Chandunika, R. K.; Sahu, Niroj Kumar; Parthipan, G.; Muralidharan, R.

doi:10.1016/j.ceramint.2022.05.078

Cited by 11 publications

(5 citation statements)

References 16 publications

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“…The calculated value of K eff was found to be equal to 7.485 × 10 4 (erg/m 3 ), which agrees with previously reported values for MNPs [ 11 , 17 ]. As shown in Equation (8) below, the anisotropy has an essential role in enhancing the Néel relaxation time; hence, higher anisotropy values lead to a higher relaxation time as well as the ability of the particles to be tuned under lower frequencies [ 18 , 19 , 20 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…This is directly related to several other factors that will be discussed in the subsequent sections. Along with SAR values, the maximum obtained temperature and the time to reach the hyperthermia temperature (42 °C) are also other important parameters that assess the self-heating abilities of MNPs [ 21 ]. Nonetheless, all the used concentrations (2.5–10 mg/mL) caused relatively high SAR values and reached hyperthermia temperatures (42 °C) in relatively short times, which indicate the excellent heating efficiencies of the MNPs.…”

Section: Resultsmentioning

confidence: 99%

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Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field

et al. 2023

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Magnetite nanoparticles (MNPs) exhibit favorable heating responses under magnetic excitation, which makes them particularly suited for various hyperthermia applications. Herein, we report the detailed self-heating mechanisms of MNPs prepared via the Ko-precipitation Hydrolytic Basic (KHB) methodology. The as-prepared MNPs were fully characterized using various spectroscopic techniques including transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), and vibrating sample magnetometry (VSM). MNPs exhibited stable 15 nm quasi-spherical small-sized particles, pure crystalline cubic Fe3O4 phases, high saturation magnetizations (Ms = ~40 emu·g−1), and superparamagnetic behavior. In response to alternating magnetic fields (AMFs), these MNPs displayed excellent self-heating efficiencies with distinctive heating responses, even when minimal doses of MNPs were used. Heating efficacies and specific absorption rate (SAR) values as functions of concentration, frequency, and amplitude were systematically investigated. Remarkably, within only a few minutes, MNPs (2.5 mg/mL) showed a rapid dissipation of heat energy, giving a maximum intrinsic loss power (ILP) of 4.29 nHm2/kg and a SAR of 261 W/g. Hyperthermia temperatures were rapidly reached in as early as 3 min and could rise up to 80 °C. In addition, Rietveld refinement, Langevin, and linear response theory (LRT) models were studied to further assess the magnetic and heating mechanisms. The LRT model was used to determine the Néel relaxation time (τR = 5.41 × 10−7 s), which was compared to the Brownian relation time value (τR = 11 × 10−7 s), showing that both mechanisms are responsible for heat dissipated by the MNPs. Finally, the cytotoxicity assay was conducted on aqueous dispersions of MNPs, indicating their biocompatibility and low toxicity. Our results strongly suggest that the as-prepared Fe3O4 MNPs are promising vehicles for potential magnetically triggered biomedical hyperthermia applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field

et al. 2023

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“…These effects are related to the carbon content oxidation originated from the organic biomolecules of plant materials. Thus, one can affirm that the incorporation of bioactive compounds of the plant extracts on the surface or in the pores of MNPs occurred [ 81 ]. Therefore, considering the results obtained, and corroborating with those from the XRD analysis, it can be stated that the synthesis of MNPs at 25 °C, starting from the ethanolic extracts of green tea and basil, leads to the formation of a mixture of magnetite (as the predominant phase) and maghemite (probably in traces).…”

Section: Discussionmentioning

confidence: 99%

Biologic Impact of Green Synthetized Magnetic Iron Oxide Nanoparticles on Two Different Lung Tumorigenic Monolayers and a 3D Normal Bronchial Model—EpiAirwayTM Microtissue

et al. 2022

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The present study reports the successful synthesis of biocompatible magnetic iron oxide nanoparticles (MNPs) by an ecofriendly single step method, using two ethanolic extracts based on leaves of Camellia sinensis L. and Ocimum basilicum L. The effect of both green raw materials as reducing and capping agents was taken into account for the development of MNPs, as well as the reaction synthesis temperature (25 °C and 80 °C). The biological effect of the MNPs obtained from Camellia sinensis L. ethanolic extract (Cs 25, Cs 80) was compared with that of the MNPs obtained from Ocimum basilicum L. ethanolic extract (Ob 25, Ob 80), by using two morphologically different lung cancer cell lines (A549 and NCI-H460); the results showed that the higher cell viability impairment was manifested by A549 cells after exposure to MNPs obtained from Ocimum basilicum L. ethanolic extract (Ob 25, Ob 80). Regarding the biosafety profile of the MNPs, it was shown that the EpiAirwayTM models did not elicit important viability decrease or significant histopathological changes after treatment with none of the MNPs (Cs 25, Cs 80 and Ob 25, Ob 80), at concentrations up to 500 µg/mL.

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“…Cancer is a widespread condition characterized by the uncontrolled proliferation of aberrant cells, which can spread to diverse body regions, encompassing over a hundred distinct forms [ 1 – 2 ]. Current cancer treatments lack a complete approach, as they mostly rely on radiotherapy, chemotherapy, immunotherapy, and surgery in clinical environments [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

Özcan,

Hazar Yoruç

2024

Beilstein J. Nanotechnol.

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In this study, a multifunctional therapeutic agent combining chemotherapy and photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight ratios as a result of dopamine polymerisation and covalent bonding of thiol-polyethylene glycol (SH-PEG). The VNB/PDA/Fe3O4 nanoparticles have a saturation magnetisation value of 60.40 emu/g in vibrating sample magnetometry, which proves their magnetisation. Vinorelbine, which is used as an effective cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design, magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research.

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Cytotoxic effect of functionalized superparamagnetic samarium doped iron oxide nanoparticles for hyperthermia application

Cited by 11 publications

References 16 publications

Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field

Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field

Biologic Impact of Green Synthetized Magnetic Iron Oxide Nanoparticles on Two Different Lung Tumorigenic Monolayers and a 3D Normal Bronchial Model—EpiAirwayTM Microtissue

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

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