Cytotoxic interaction between gorgonian explants: Mode of action

Theodor, Jacques; Senelar, R

doi:10.1016/0008-8749(75)90203-8

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…In many cellular systems, stimulation of death receptors disrupts anti‐apoptosis pathways (187). Given the importance of apoptosis in allorecognition in Cnidaria (188), it was worth looking at the possible conservation of this feature at the level of very primitive organisms. indeed shows the presence of such domain in diploblastic organisms and in more advanced phyla as well.…”

Section: Itim‐containing Molecules Not Directly Involved In Immunitymentioning

confidence: 99%

Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future

Daëron

Jaeger

Pasquier

et al. 2008

Immunological Reviews

322

284

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Since an immunoreceptor tyrosine-based inhibition motif (ITIM) was first identified in the intracytoplasmic domain of Fc gammaRIIB, ITIMs have been found in a large number of inhibitory molecules that were shown to negatively regulate cell activation. Due to their wide tissue distribution and to the variety of their extracellular ligands, ITIM-containing molecules are involved in the control of a large spectrum of biological functions, mostly but not exclusively related to immunity. On the basis of sequence comparison, ITIMs were structurally defined as 6-amino acid sequences containing a tyrosine (Y) with loosely conserved N-terminal (Y-2) and C-terminal (Y+3) residues. Molecular analysis of signaling events demonstrated that when coaggregated with activating receptors, ITIMs are phosphorylated by Src-family tyrosine kinases, which enables them to recruit Src homology 2 domain-containing phosphatases that antagonize activation signals. Because ITIM-dependent negative regulation seems to be a fundamental regulatory mechanism, both in rodents and in humans, and because it can be used either as a target or as a powerful tool in various diseases, we undertook (i) a genome-wide search of potential novel ITIM-containing molecules in humans, mice, frogs, birds, and flies and (ii) a comparative analysis of potential ITIMs in major animal phyla, from mammals to protozoa. We found a surprisingly high number of potential ITIM-containing molecules, having a great diversity of extracellular domains, and being expressed by a variety of immune and non-immune cells. ITIMs could be traced back to the most primitive metazoa. The genes that encode ITIM-containing molecules that belong to the immunoglobulin superfamily or to the C-lectin family seem to derive from a common set of ancestor genes and to have dramatically expanded and diverged in Gnathostomata (from fish to mammals).

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Section: Itim‐containing Molecules Not Directly Involved In Immunitymentioning

confidence: 99%

Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future

Daëron

Jaeger

Pasquier

et al. 2008

Immunological Reviews

322

284

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“…True tissue fusions between allogeneic adult colonies are not common in the Cnidaria, although they have been documented in the Hydrozoa (Hauenschild, 1954(Hauenschild, , 1956Buss et al, 1985;Shenk, 1991;Frank and Rinkevich, 1994). Most histocompatibility related studies in the Cnidaria (reviewed by Leddy and Green, 1991) have been carried out on scleractinian corals (Potts, 1976;Hildemann et al, 1977;Criens, 1982 Rinkevich andLang and Chornesky, 1990;Chadwick-Furman and Rinkevich, 1994;Rinkevich et al, 1994), hydrozoans (Hauenschild, 1954(Hauenschild, , 1956Ivker, 1972;Miiller et al, 1983;Buss et al, 1984Buss et al, , 1985Bosch and David, 1986;Lange et al, 1989;Frank and Rinkevich, 1994) and gorgonians (Theodor, 1970;Theodor and Senelar, 1975;Theodor, 1976;Bigger and Runyan, 1979;Lasker and Coffroth, 1985;Salter-Cid and Bigger, 1991). Little is known, however, about allogeneic responses in soft bodied alcyonaceans.…”

Section: Introductionmentioning

confidence: 99%

Allorecognition responses in the soft coral Parerythropodium fulvum fulvum from the Red Sea

Frank

Bak

Rinkevich

1996

Journal of Experimental Marine Biology and Ecology

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Allorecognition responses in the soft coral Parerythropodium fulvum fulvum from the Red Sea. Frank, U.; Bak, R.P.M.; Rinkevich, B. Published in: Journal of Experimental Marine Biology and Ecology Link to publication Citation for published version (APA):Frank, U., Bak, R. P. M., & Rinkevich, B. (1996). Allorecognition responses in the soft coral Parerythropodium fulvum fulvum from the Red Sea. Journal of Experimental Marine Biology and Ecology, (197),[191][192][193][194][195][196][197][198][199][200][201]. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. AbstractAllogeneic encounters were experimentally arranged in Eilat, Red Sea for the first time in the Alcyonacea with the soft coral Pareryfkpodium ft.&urn fulvum. All possible pairwise combination assays within two groups of five colonies each and one group of three colonies were setup in situ in 2-4 replicates each (a total of 76 assays). Control isogeneic encounters always resulted in complete tissue fusion. Two types of allogeneic responses were documented following tissue-totissue contacts. The first was retreat growth, in which contacting allografts started to retreat from each other a few days following direct contact until a bare area of a few mm separated them. In several assays the colonies repeatedly grew into contact and retreated again. The second allogeneic response was unilateral or reciprocal tissue overgrowth. In this type of response one colony overgrew the conspecific partner by several mm and then stopped. The underlying tissue of the overgrown partner died. No cytotoxicity was observed in allogeneic contacts either in growing parts or when assays were established between cut surface areas. Repeated assays of the same pair-combination were not consistent in terms of type and directionality of responses. We propose that effector mechanisms elicited following allogeneic encounters in P. J fulvum may be affected by biological as well as non-biological parameters and are not specific to the type of allogeneic challenge. However, colony specificity in this species is restricted only to the level of self-and non-self discrimination.

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“…The gorgonians (Anthozoa; Alcyonaria) are an Order of soft corals that includes sea fans and sea whips. Theodor's extensive studies (Theodor, 1966(Theodor, , 1969(Theodor, , 1970(Theodor, , 1976Serre and Theodor, 1967;Theodor and Carriere, 1975;Theodor and Senelar, 1975) of Eunicella stricta and Lophogorgia sarmentosa, and the preliminary work of Bigger and Runyan ( 1979) on Leptogorgia virgulata, Pseudopterogorgia elisabethae and Plexuraflexulosa, have identified some of the major characteristics of histocompatibility in the Order. Naturally occurring grafts within the same colony (autografts) occur in field, and all experimentally induced autografts rapidly fuse within 24 h. (Theodor, 1970;Bigger and Runyan, 1979).…”

Section: Introductionmentioning

confidence: 99%

Alloimmunity in the Gorgonian Coral Swiftia exserta

Salter–Cid

Bigger

1991

The Biological Bulletin

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This study of histocompatibility demonstrates that the gorgonian Swiftia exserta (Coelenterata, Anthozoan) fulfills the minimal functional criteria of cytotoxicity, specificity, and altered secondary response (memory) that characterize an adaptive immune response. All autografts (self grafts) fused, and all allografts (intraspecific grafts) underwent rejection, which is characterized by rapid and progressive blanching, necrosis, and loss of tissue in the immediate contact area. Initial reactions required 7-9 days to produce 1 mm of necrosis, but after a resting period, a second contact at a new tissue area yielded the same reaction in 3-4 days. After primary sensitization, intervals of up to eight weeks still produced a significantly accelerated secondary response. Significant differences between the reaction times of second set and third party allografts demonstrated recognition specificity in these responses. Thus, this is the first report of an adaptive alloimmune response in gorgonians.

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Cytotoxic interaction between gorgonian explants: Mode of action

Cited by 13 publications

References 5 publications

Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future

Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future

Allorecognition responses in the soft coral Parerythropodium fulvum fulvum from the Red Sea

Alloimmunity in the Gorgonian Coral Swiftia exserta

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