Cytotoxic Oleanane‐Type Saponins from the Leaves of Albizia anthelminticaBrongn.

Abstract

Two new oleanane-type saponins: β-d-xylopyranosyl-(1 → 4)-6-deoxy-α-l-mannopyranosyl-(1 → 2)-1-O-{(3β)-28-oxo-3-[(2-O-β-d-xylopyranosyl-β-d-glucopyranosyl)oxy]olean-12-en-28-yl}-β-d-glucopyranose (1) and 1-O-[(3β)-28-oxo-3-{[β-d-xylopyranosyl-(1 → 2)-α-l-arabinopyranosyl-(1 → 6)-2-acetamido-2-deoxy-β-d-glucopyranosyl]oxy}olean-12-en-28-yl]β-d-glucopyranose (2), along with two known saponins: (3β)-3-[(β-d-Glucopyranosyl-(1 → 2)-β-d-glucopyranosyl)oxy]olean-12-en-28-oic acid (3) and (3β)-3-{[α-l-arabinopyranosyl-(1 → 6)-[β-d-glucopyranosyl-(1 → 2)]-β-d-glucopyranosyl]oxy}olean-12-en-28-oic acid (4) were isolated from the acetone-insoluble fraction obtained from the 80% aqueous MeOH extract of Albizia anthelmintica Brongn. leaves. Their structures were identified using different NMR experiments including: H- and C-NMR, HSQC, HMBC and H, H-COSY, together with HR-ESI-MS/MS, as well as by acid hydrolysis. The four isolated saponins and the fractions of the extract exhibited cytotoxic activity against HepG-2 and HCT-116 cell lines. Compound 2 showed the most potent cytotoxic activity among the other tested compounds against the HepG2 cell line with an IC value of 3.60μm. Whereas, compound 1 showed the most potent cytotoxic effect with an IC value of 4.75μm on HCT-116 cells.

Anticancer Phenolics from Dryopteris fragrans (L.) Schott

“…The sugars in the aquatic layer were monitored by Thin-Layer Chromatography (TLC) with BuOH–H 2 O–AcOH (40:10:50, v / v / v , upper BuOH layer) as a developing system when compared with authentic sugars. The TLC plate was sprayed with a vanillin–H 2 SO 4 solvent [ 20 ].…”

Chemical Characteristics, Antimicrobial, and Cytotoxic Activities of the Essential Oil of Egyptian Cinnamomum glanduliferum Bark

“…So, we need for new drugs that have anticancer activities with low toxicity to normal cells. Novel natural products offer chances for innovation in cancer drug (prevention and therapy), as a huge number of natural compounds proved its toxicity against cancer cell lines …”

Melanogenesis-Inhibitory and Cytotoxic Activities of Triterpene Glycoside Constituents from the Bark of Albizia procera

“…14,20−22 Acacic acid lactone-type and echinocystic acid-type triterpene glycosides were also isolated from A. procera, Albizia inundata, and Acacia ligulata, 15,16,23,24 while oleanolic acid-type triterpene glycosides were isolated from Albizia anthelmintica. 25,26 Some of these naturally occurring triterpene glycosides may also contain Nacetylglucosamine, with such compounds exhibiting antiproliferative activities. 27,28 The melanogenesis inhibitory activity and safety of compounds 1−5 were determined in α-MSH-stimulated B16 melanoma cells and B16 melanoma cells, respectively.…”

“…It is noteworthy that triterpenoid glycosides have been encountered frequently in Albizia species. ,− Acacic acid lactone-type and echinocystic acid-type triterpene glycosides were also isolated from A. procera, Albizia inundata, and Acacia ligulata, ,,, while oleanolic acid-type triterpene glycosides were isolated from Albizia anthelmintica. , Some of these naturally occurring triterpene glycosides may also contain N -acetylglucosamine, with such compounds exhibiting antiproliferative activities. , …”