Cytotoxic Polyketides from the Marine Sponge Discodermia calyx

Shinde, Pramod B.; Mansoor, Tayyab A.; Luo, Xuan; Hong, Jongki; Lee, Chong O.; Jung, Jee H.

doi:10.5012/bkcs.2007.28.6.990

Cited by 12 publications

(1 citation statement)

References 27 publications

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“…23) The filamentous bacterium was identified as Entotheonella based on the 16S rRNA analysis. In the Discodermia sponges from the seas around Japan, discodermolide has not been reported, but discodermin, 24) discokiolide, 25) and lipodiscamide 26) have been isolated from Discodermia kiiensis, and calyculin A, 27) calyxamide, 28) kasumigamide, 29) and icadamides 30) have been isolated from Discodermia calyx (Fig. 4).…”

Section: Natural Product Biosynthesis In the Sponge Genus Discodermiamentioning

confidence: 99%

Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges

Wakimoto

2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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Marine sponges are among the most primitive animals and often contain unique, biologically active compounds. Several of these compounds have played an important roles as pharmaceutical leads for anti-cancer drugs, such as halichondrin B, which led to the development of an anti-breast cancer drug. Some compounds with remarkable biological activities are accumulated in significantly high concentrations in the sponge. How and why the marine sponges produce and accumulate bioactive natural products are long-standing questions with both biochemical and ecological implications, since in sponges, the animal-microbe symbioses are presumed to be responsible for the biosynthetic machinery, consisting of efficient enzymes and regulatory systems for the specific biological activities of medicinally relevant natural products. In this review, I focus on the chemically rich Theonellidae family sponges and discuss the biosynthesis of bioactive peptides and polyketides. In particular, the biosynthetic pathway of calyculin A suggests that crosstalk between the sponge host and bacterial symbiont confers a chemical defense system on the immobile animal-microbe holobiont.

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Section: Natural Product Biosynthesis In the Sponge Genus Discodermiamentioning

confidence: 99%

Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges

Wakimoto

2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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Porifera (Sponges)–3

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: Secondary Metabolites of Haplosclerida Acetylenic Derivatives 1‐Glyceryl Ethers from the Assemblage Ceratodictyon/Spongiosum/Haliclona/Cymaeformis Atypical Fatty Acids Terpenes and Meroterpenes Triterpenic Glycosides Hopanoids, Steroids and Sterosides Macrolides, Depsipeptides, and Cyclic Peptides Aminoalcohols and Glycosphingolipids (Cerebrosides) Manzamines and Related Derivatives Quinolizidine and 1‐Oxaquinolizidine Derivatives Pyridine Derivatives and 3‐alkylpyridinium Salts Pyridoacridine Alkaloids Pyrroloquinones and Other Examples of Nitrogen‐Containing Heterocycles Quinones and Sulfated Hydroquinones Very Long‐Chain Linear Sulfated Derivatives Thiocyanatins: α,ω‐Dithiocyanates of Oceanapia sp Some Information on Freshwater Haplosclerid Sponges Secondary Metabolites of Poecilosclerida Sterols, Steroids, and Sterosides Terpenes and Triterpenic Glycosides Polybrominated Acetogenins and Oxylipins Long‐Chain Acetylenic Derivatives: Raspailynes Glycolipids Brominated Aromatic Derivatives of Hamigera tarangaensis Macrolides Chondropsins: Cyclic Depsipeptides of Chondropsis sp Eurypamides ( Microciona eurypa ), Microcionamides ( Clathria abietina ) and Other Cyclic Peptides Linear Amides and Peptides Examples of Some Atypical Sulfur‐Containing Derivatives Pyrrole and Indole Derivatives Pyridines, Quinolizines, and Pyridoacridines Guanidine Derivatives Pyrroloiminoquinones and Pyrroloquinones Azasugars and Cyclic Amines Other Examples of Polycyclic Alkaloids Phosphorus‐ and Arsenic‐Containing Derivatives, Betaines

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Porifera (Sponges)–5

Kornprobst

2014

Encyclopedia of Marine Natural Products

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Cytotoxic Polyketides from the Marine Sponge Discodermia calyx

Cited by 12 publications

References 27 publications

Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges

Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges

Porifera (Sponges)–3

Porifera (Sponges)–5

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