Cytotoxic triterpene diglycosides from the sea cucumber Stichopus horrens

Cuong, Nguyen Xuan; Vien, Le Thi; Hoàng, Lê Tuấn Anh; Hạnh, Trần Thị Hồng; Thảo, Đỗ Thị; Thành, Nguyễn Văn; Nam, Nguyễn Hoài; Thung, Đỗ Công; Kiệm, Phan Văn; Minh, Châu Văn

doi:10.1016/j.bmcl.2017.05.003

Cited by 33 publications

(20 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other mentioned triterpene glycosides demonstrated moderate cytotoxicity. Evaluation of the relationships between structure and cytotoxic activity of these active compounds suggested that the crucial factor is the presence of quinovose and the second xylose residues in the disaccharide chains as well as acetoxyl groups in side chains [ 9 ].…”

Section: Biologically Active Compounds With Anticancer Activitymentioning

confidence: 99%

“…They have gained a lot of attention from researchers worldwide within recent decades because of their nutritive values [ 4 ] as well as their beneficial influence on human health and possible therapeutic uses. The spectrum of active compounds chemically identified from these animals is quite diverse and includes polysaccharides such as glycosaminoglycans (mucopolysacharides) including neutral glycans, fucosylated chondroitin sulfates and sulfated fucans, peptides, phospholipids and glycolipids, including glycosphingolipids (cerebrosides), polyunsaturated fatty acids, phenols, and triterpene glycosides (saponins) [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. In this review, the main attention is given to the compounds for which pharmacological activity has been scientifically demonstrated, physico-chemical properties required for their further standardization have been described and their mechanisms of action are more or less clear ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological Potential of Sea Cucumbers

Khotimchenko

2018

IJMS

136

103

View full text Add to dashboard Cite

This review presents a detailed analysis of published research data focused on the pharmacological activity exerted by biologically active compounds isolated from sea cucumbers belonging to the class of Holothuroidea, phylum Echinodermata. The review contains descriptions of the structure, physico-chemical properties and pharmacological effects of these active substances. Particular attention is given to compounds with anticoagulant, antithrombotic, antioxidant, anticancer, anti-infectious, immune-stimulating and anti-ACE (angiotensin converting enzyme) activities as well as to the substances exerting a regulating influence on lipid and carbohydrate metabolism. All these compounds may be considered as prototypes for development of new pharmaceutical substances and medicines.

show abstract

Section: Biologically Active Compounds With Anticancer Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological Potential of Sea Cucumbers

Khotimchenko

2018

IJMS

136

103

View full text Add to dashboard Cite

show abstract

“…However, most of these studies focused on only a few types of cancers, such as breast cancer, pancreatic cancer, and leukemia. To date, few studies describing the effect of sea cucumber or its components on PCa have been reported, and its mechanisms of in vivo or in vitro anticancer/antitumor activities are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Sea cucumber extract TBL‐12 inhibits the proliferation, migration, and invasion of human prostate cancer cells through the p38 mitogen‐activated protein kinase and intrinsic caspase apoptosis pathway

et al. 2019

View full text Add to dashboard Cite

Background: Sea cucumber is a kind of nutritious echinoderm that has multiple biological activities, including antioxidant, antibacterial, and antitumor activities.However, there is no extensive study on the antitumor effect of sea cucumber extract on prostate cancer (PCa). TBL-12 is a new sea cucumber extract. In this study, we investigated the in vivo anti-PCa effect of TBL-12 and its in vitro effects on the proliferation, apoptosis, migration, and invasion of the human PCa cell lines LNCaP, 22RV1, PC-3, and DU145, and evaluated its possible mechanisms. Methods: Cell proliferation was analyzed by cell counting kit-8 and colony formation assays. Scratch migration assay and transwell invasiveness assay were used to observe TBL-12 effect on the migration and invasion of PCa cells. Matrix metalloproteinase 2 (MMP-2) and MMP-9 expression and enzymatic activity was determined by Western blot analysis, quantitative reverse-transcription polymerase chain reaction, and gelatin zymography. Apoptosis level was detected by flow cytometry analysis. Western blot analysis was used to analyze p38 mitogen-activated protein kinase (MAPK) and apoptosis pathways. Angiogenic array analysis was used to explore autocrine and paracrine growth factors in PCa cell lines. Xenograft tumor model was built to observe the in vivo anticancer effect. Results: TBL-12 could significantly inhibit tumor growth in xenograft PCa mice in vivo, and dramatically inhibit the proliferation, colony formation, migration, and invasiveness of PCa cells in vitro (P < 0.05 and P < 0.001). The expression and enzyme activity of MMP-2 and MMP-9 were significantly suppressed by TBL-12 (P < 0.01), and decreased phosphorylation level of p38 in PCa cells was detected (P < 0.001). Furthermore, TBL-12 could reinforce the MMP-2/MMP-9 inhibitory effect of SB203580, a specific inhibitor of the p38 MAPK pathway (P < 0.05). Besides, TBL-12 could induce the apoptosis of PCa cells by activating caspase-9, caspase-7, and poly(ADP-ribose) polymerase and suppressing survivin, and inhibit The Prostate. 2019;79:826-839. wileyonlinelibrary.com/journal/pros 826 | 1 Yuan and Huang contributed equally to this study. the secretion of angiogenin, angiopoietin-2, and vascular endothelial growth factor in PCa cells. Conclusions: Sea cucumber extract TBL-12 could suppress the proliferation and metastasis of human PCa cells by inhibiting MMP-2 and MMP-9 via blocking the p38 MAPK pathway, inducing apoptosis through intrinsic caspase apoptosis pathway and inhibiting the secretion of angiogenic factors. Our findings may be of importance and significance for the research and clinical applications of sea cucumber extract in PCa treatment. K E Y W O R D S apoptosis, matrix metalloproteinases, prostate cancer, sea cucumber extract, tumor metastasis SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Yuan L, Huang X, Zhou K, et al. Sea cucumber extract TBL-12 inhibits the proliferatio...

show abstract

“…Các saponin ở hải sâm là các tritecpen glycosit, hầu hết thuộc khung holostane, còn các saponin từ sao biển lại là các asterosaponin, các steroit glycosit. Từ loài hải sâm Stichopus chloronotus, một hợp chất saponin mới là stichloroside F (1) cùng với stichoposide D (2), stichloroside A 2 (3), stichoposide E (4), neothyonidioside (5) và holothurin B (6) đã được phân lập và xác định cấu trúc. [2] Hợp chất 6 và echinoside B (7) cũng được phân lập từ hải sâm Holothuria atra.…”

Section: Nhóm Chất Saponinunclassified

“…Các hợp chất 17 và 20 thể hiện hoạt tính đáng kể với IC 50 từ 5,28 đến 11,00 µM, trong khi các hợp chất còn lại thể hiện hoạt tính trung bình với giá trị IC 50 từ 33,48 đến 59,31 µM. [5] Từ loài sao biển Astropecten monacanthus, bốn hợp chất asterosaponin mới là astrosterioside A−D (23-25 và 27), cùng với hai hợp chất đã biết là psilasteroside (26) và marthasteroside B (28) đã được phân lập và xác định cấu trúc. [6] Hai hợp chất 26 và 28 gần đây được nhóm tác giả phân lập từ loài sao biển Astropecten polyacanthus.…”

Section: Nhóm Chất Saponinunclassified

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

Cường¹,

Nhiệm²,

Thành³

et al. 2018

Vietnam Journal of Chemistry

View full text Add to dashboard Cite

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn AbstractThis paper reviews the investigations on marine natural products in Vietnam published in period of 2013-2017 from sponges, corals, echinoderms, mollusks, and microorganisms. About 415 compounds were isolated and structure elucidated including 33 saponins (15 new compounds), 143 steroids (30 new compounds), 38 steroid glycosides (20 new compounds), 33 diterpenes (20 new compounds), 53 sesquiterpenes (27 new compounds), 12 cyclopeptides, 7 pyrrole and furan oligoglycosides (6 new compounds), 10 biscembranoids (2 new compounds), 15 triterpenes (14 new compounds), and 71 other compounds (8 new compounds). Many compounds have unique structures and exhibited potential biological effects including cytotoxic, anti-inflammatory, and anti-microbial activities.

show abstract

Cytotoxic triterpene diglycosides from the sea cucumber Stichopus horrens

Cited by 33 publications

References 10 publications

Pharmacological Potential of Sea Cucumbers

Pharmacological Potential of Sea Cucumbers

Sea cucumber extract TBL‐12 inhibits the proliferation, migration, and invasion of human prostate cancer cells through the p38 mitogen‐activated protein kinase and intrinsic caspase apoptosis pathway

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

Contact Info

Product

Resources

About