Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

Abstract

To investigate the potential cytotoxicity of copper(II)-based complexes, three coordination compounds with heterocyclic ligands, Cu(pbmbt)Cl 2 (CH 3 OH) (1), Cu 2 (ddbib) 2 (NO 3 ) 4 ·3CH 3 OH (2), and Cu 3 (ttmtmb) 2 Cl 6 ·2.5H 2 O (3), which include mononuclear, dinuclear, and trinuclear structures, have been synthesized from reactions of corresponding copper(II) salts with 1-imidazole (ddbib), and 1,1′,1′′-((2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene)tris(2-methyl-1H-benzoimidazole) (ttmtmb), respectively. IC 50 values revealed that 2 and 3 show strong cytotoxicity, whereas 1 is weakly cytotoxic after being tested against a panel of several human alimentary system carcinoma cell lines (SGC7901, EC109, SMMC7721, and HT29). The number of copper centers and different structures could make a tremendous difference on their cytotoxicity. Three coordination compounds with heterocyclic ligands were constructed to investigate the potential cytotoxicity of copper(II)-based complexes. IC 50 values revealed that complexes 2 and 3 show strong cytotoxicity, whereas complex 1 is weakly cytotoxic after being tested by MTT assay against a panel of several human alimentary system carcinoma cell lines.

Synthesis, structure, computational, antimicrobial andin vitroanticancer studies of copper(II) complexes with N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine and tris(2-hydroxyethyl)amine

“…The IC 50 value of synthesized complexes compares well with those reported for cytotoxic copper(II) complexes giving IC 50 values in similar concentration range [11][12][13][14][15]. This study suggests that 1 and 2 have potential as anticancer agents.…”

“…Copper(II) complexes with heterocyclic ligands also possess strong cytotoxicity against several human alimentary carcinoma cell lines [12]. The in vitro cytotoxicity of a copper(II) complex towards cell lines was reported and such complexes may play an important role in cytotoxic activities [13].…”

Influence of d-Electron Divalent Metal Ions in Complex Formation with L-Tartaric and L-Malic Acids

“…Metal ions, which are found in living organisms, occur at the active sites of numerous enzymes and play a key role in them. Their complexes are interesting as model compounds of active sites of biological enzymes [ 1 , 2 , 3 , 4 , 5 , 6 ]. The divalent copper, cobalt, and nickel ions are examples of such metal ions.…”