Czech Working Group for Paediatric Gastroenterology and Nutrition guidelines for diagnostics and treatment of inflammatory bowel diseases in children – 1st edition update

Bronský, Jiří; Beránková, Katarína; Černá, Zuzana; Copova, Ivana; Durilová, Marianna; Hradský, Ondřej; Karásková, Eva; Mitrová, Katarína; Nevoral, Jiří; Poš, Lucie; Schwarz, Jan; Szitányi, Peter; Škába, Richard; Šuláková, A.; Tuková, Jana

doi:10.14735/amgh201711

Cited by 3 publications

(1 citation statement)

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“…We then undertook to create a candidate model for predicting early relapse of the disease. Patients received initial standardized treatment with mesalazine and/or corticosteroids guided by the PUCAI according to relevant national guidelines [ 17 ] and were evaluated for adherence to therapy by use of structured interview. We monitored whether after standard treatment a patient experienced an early relapse during the first year of treatment despite significant initial remission of the disease, defined as PUCAI < 10 during the first 3 months after diagnosis and fecal calprotectin <100 ug/L.…”

Section: Methodsmentioning

confidence: 99%

MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification

Jabandžiev

Kakisaka

Bohošová

et al. 2021

JCM

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Prevalence of inflammatory bowel disease has been on the rise in recent years, especially in pediatric populations. This study aimed to provide precise identification and stratification of pediatric patients with diagnosed ulcerative colitis (UC) according to the severity of their condition and the prediction for standard treatment according to the specific expression of candidate miRNAs. We enrolled consecutive, therapeutically naïve, pediatric UC patients with confirmed pancolitis. We examined formalin-fixed paraffin-embedded specimens of colonic tissue for the expression of 10 selected candidate miRNAs. We performed receiver operating characteristic curve analysis, using area under the curve and a logistic regression model to evaluate the diagnostic and predictive power of the miRNA panels. Sixty patients were included in the final analysis. As a control group, 18 children without macroscopic and microscopic signs of inflammatory bowel disease were examined. The combination of three candidate miRNAs (let-7i-5p, miR-223-3p and miR-4284) enabled accurate detection of pediatric UC patients and controls. A panel of four candidate miRNAs (miR-375-3p, miR-146a-5p, miR-223-3p and miR-200b-3p) was associated with severity of UC in pediatric patients and a combination of three miRNAs (miR-21-5p, miR-192-5p and miR-194-5p) was associated with early relapse of the disease. Nine patients out of the total were diagnosed with primary sclerosing cholangitis (PSC) simultaneously with ulcerative colitis. A panel of 6 candidate miRNAs (miR-142-3p, miR-146a-5p, miR-223-3p, let-7i-5p, miR-192-5p and miR-194-5p) identified those patients with PSC. Specific combinations of miRNAs are promising tools for potential use in precise disease identification and severity and prognostic stratification in pediatric patients with ulcerative pancolitis.

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Section: Methodsmentioning

confidence: 99%

MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification

Jabandžiev

Kakisaka

Bohošová

et al. 2021

JCM

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Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease

et al. 2020

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Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study

Filip,

Vojtíšek,

Jičínská

et al. 2024

Front. Neurosci.

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BackgroundThe research on possible cerebral involvement in Crohn’s disease (CD) has been largely marginalized and failed to capitalize on recent developments in magnetic resonance imaging (MRI).ObjectiveThis cross-sectional pilot study searches for eventual macrostructural and microstructural brain affection in CD in remission and early after the disease onset.Methods14 paediatric CD patients and 14 healthy controls underwent structural, diffusion weighted imaging and quantitative relaxation metrics acquisition, both conventional free precession and adiabatic rotating frame transverse and longitudinal relaxation time constants as markers of myelination, iron content and cellular loss.ResultsWhile no inter-group differences in cortical thickness and relaxation metrics were found, lower mean diffusivity and higher intracellular volume fraction were detected in CD patients over vast cortical regions essential for the regulation of the autonomous nervous system, sensorimotor processing, cognition and behavior, pointing to wide-spread cytotoxic oedema in the absence of demyelination, iron deposition or atrophy.ConclusionAlthough still requiring further validation in longitudinal projects enrolling larger numbers of subjects, this study provides an indication of wide-spread cortical oedema in CD patients very early after the disease onset and sets possible directions for further research.

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Czech Working Group for Paediatric Gastroenterology and Nutrition guidelines for diagnostics and treatment of inflammatory bowel diseases in children – 1st edition update

Cited by 3 publications

References 0 publications

MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification

MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification

Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease

Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study

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