D-dimer and right ventricular abnormalities as prognostic factors in critically ill COVID-19 patients

González-Fernández, Óscar; Antonio, Inés Ponz de; Rodriguez, S O Rosillo; Cantador, José Ruiz; Iglesias, J.C. Figueira; Hentschel, José Luis López-Sendón

doi:10.1016/j.rec.2020.07.004

Cited by 3 publications

(5 citation statements)

References 7 publications

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“… 24 Studies focusing on patients in the ICU, or with a high proportion of intubated patients, report an incidence of LV dysfunction of 11–21% and RV dysfunction of 19–33%. 17 , 23 , 25 , 26 In one previous study of Scandinavian COVID‐19 patients in the ICU, the prevalence of LV and RV dysfunction was 21% and 32%, respectively. 27 Our results are in line with these studies, although comparisons are uncertain due to heterogeneities in the study population and the definitions and measurements used.…”

Section: Discussionmentioning

confidence: 99%

“…A recent systematic review and meta‐analysis has reported a prevalence of RV dysfunction of 20% in hospitalised COVID‐19 patients 24 . Studies focusing on patients in the ICU, or with a high proportion of intubated patients, report an incidence of LV dysfunction of 11–21% and RV dysfunction of 19–33% 17,23,25,26 . In one previous study of Scandinavian COVID‐19 patients in the ICU, the prevalence of LV and RV dysfunction was 21% and 32%, respectively 27 .…”

Section: Discussionmentioning

confidence: 99%

“…Other cardiac manifestations include myocarditis, 7,8 Takotsubo cardiomyopathy 9,10 and cardiac dysfunction related to multisystem inflammatory syndrome in children and adults (MIS‐C/A) 11,12 . Several studies have reported abnormalities in heart function in a large proportion of patients with COVID‐19 undergoing echocardiography 10,13,14 and both left‐ and right ventricular dysfunction seem to be independently correlated to mortality in patients with COVID‐19 13,15‐17 . However, incidence and influence on mortality of cardiac complications in critically ill patients with COVID‐19 in Sweden are not sufficiently studied.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 Several studies have reported abnormalities in heart function in a large proportion of patients with COVID-19 undergoing echocardiography 10,13,14 and both left-and right ventricular dysfunction seem to be independently correlated to mortality in patients with COVID-19. 13,[15][16][17] However, incidence and influence on mortality of cardiac complications in critically ill patients with COVID-19 in Sweden are not sufficiently studied.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac dysfunction and mortality in critically ill patients with COVID‐19: A Swedish multicentre observational study

Holmqvist

Beck-Friis

Jensen

et al. 2022

Acta Anaesthesiol Scand

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Background:The prevalence and importance of cardiac dysfunction in critically ill patients with COVID-19 in Sweden is not yet established. The aim of the study was to assess the prevalence of cardiac dysfunction and elevated pulmonary artery pressure (PAP), and its influence on mortality in patients with COVID-19 in intensive care in Sweden. Methods:This was a multicentre observational study performed in five intensive care units (ICUs) in Sweden. Patients admitted to participating ICU with COVID-19 were examined with echocardiography within 72 h from admission and again after 4 to 7 days. Cardiac dysfunction was defined as left ventricular (LV) dysfunction (ejection fraction <50% and/or regional hypokinesia) or right ventricular (RV) dysfunction (defined as TAPSE <17 mm or visually assessed moderate/severe RV dysfunction). Results:We included 132 patients, of whom 127 (96%) were intubated. Cardiac dysfunction was found in 42 (32%) patients. Most patients had cardiac dysfunction at the first assessment (n = 35) while a few developed cardiac dysfunction later (n = 7) and some changed type of dysfunction (n = 3). LV dysfunction was found in 21 and | 607 HOLMQVIST eT aL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiac dysfunction and mortality in critically ill patients with COVID‐19: A Swedish multicentre observational study

Holmqvist

Beck-Friis

Jensen

et al. 2022

Acta Anaesthesiol Scand

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“…Three studies 8,12,14 included only patients hospitalized in the intensive care unit (ICU), while the remaining studies included ICU and non-ICU patients. The proportion of patients who required mechanical ventilation varied between 4% and 98%.…”

Section: Study Characteristicsmentioning

confidence: 99%

Association between right ventricular dysfunction and mortality in COVID‐19 patients: A systematic review and meta‐analysis

Diaz‐Arocutipa

Saucedo-Chinchay

Argulian

2021

Clinical Cardiology

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There is limited evidence about the prognostic utility of right ventricular dysfunction (RVD) in patients with coronavirus disease 2019 . We assessed the association between RVD and mortality in COVID-19 patients. We searched electronic databases from inception to February 15, 2021. RVD was defined based on the following echocardiographic variables: tricuspid annular plane systolic excursion (TAPSE), tricuspid S 0 peak systolic velocity, fractional area change (FAC), and right ventricular free wall longitudinal strain (RVFWLS). All meta-analyses were performed using a random-effects model. Nineteen cohort studies involving 2307 patients were included. The mean age ranged from 59 to 72 years and 65% of patients were male. TAPSE (mean difference [MD], À3.13 mm; 95% confidence interval [CI], À4.08-À2.19), tricuspid S 0 peak systolic velocity (MD, À0.88 cm/s; 95% CI, À1.68 to À0.08), FAC (MD, À3.47%; 95% CI, À6.21 to À0.72), and RVFWLS (MD, À5.83%; 95% CI, À7.47-À4.20

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Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia

Abohamr,

Abazid,

Alhumaid

et al. 2023

Front. Cardiovasc. Med.

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BackgroundRespiratory infections are one of the most common comorbidities identified in hospitalized patients. The coronavirus disease 2019 (COVID-19) pandemic greatly impacted healthcare systems, including acute cardiac services.AimThis study aimed to describe the echocardiographic findings of patients with COVID-19 infections and their correlations with inflammatory biomarkers, disease severity, and clinical outcomes.MethodsThis observational study was conducted between June 2021 and July 2022. The analysis included all patients diagnosed with COVID-19 who had transthoracic echocardiographic (TTE) scans within 72 h of admission.ResultsThe enrolled patients had a mean age of 55.6 ± 14.7 years, and 66.1% were male. Of the 490 enrolled patients, 203 (41.4%) were admitted to the intensive care unit (ICU). Pre-ICU TTE findings showed significantly higher incidence right ventricular dysfunction (28 [13.8%] vs. 23 [8.0%]; P = 0.04) and left ventricular (LV) regional wall motion abnormalities (55 [27.1%] vs. 29 [10.1%]; p < 0.001) in ICU patients compared to non-ICU patients. In-hospital mortality was 11 (2.2%), all deaths of ICU patients. The most sensitive predictors of ICU admission (p < 0.05): cardiac troponin I level (area under the curve [AUC] = 0.733), followed by hs-CRP (AUC = 0.620), creatine kinase-MB (AUC = 0.617), D-dimer (AUC = 0.599), and lactate dehydrogenase (AUC = 0.567). Binary logistic regression showed that reduced LV ejection fraction (LVEF), elevated pulmonary artery systolic pressure, and dilated right ventricle were echocardiographic predictors of poor outcomes (p < 0.05).ConclusionEchocardiography is a valuable tool in assessing admitted patients with COVID-19. Lower LVEF, pulmonary hypertension, higher D-dimer, C-reactive protein, and B-type natriuretic peptide levels were predictors of poor outcomes.

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D-dimer and right ventricular abnormalities as prognostic factors in critically ill COVID-19 patients

Cited by 3 publications

References 7 publications

Cardiac dysfunction and mortality in critically ill patients with COVID‐19: A Swedish multicentre observational study

Cardiac dysfunction and mortality in critically ill patients with COVID‐19: A Swedish multicentre observational study

Association between right ventricular dysfunction and mortality in COVID‐19 patients: A systematic review and meta‐analysis

Association between echocardiographic features and inflammatory biomarkers with clinical outcomes in COVID-19 patients in Saudi Arabia

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