D-Dimer level was associated with prognosis in metastatic colorectal cancer

Liu, Chan; Ning, Yueguo; Chen, Xiaoming; Zhu, Qian

doi:10.1097/md.0000000000019243

Cited by 21 publications

(14 citation statements)

References 29 publications

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“…DD is correlated with prognosis in patients with various malignant tumors. High DD levels are associated with poor prognosis in patients with breast cancer, renal cell carcinoma, gastric cancer, lung cancer, bladder cancers, colorectal cancers, gynecological tumors and lymphoma and sarcoma [47,[54][55][56][57][58][59][60][61]. High levels of PIC have been reported to be correlated with poor prognosis in lung cancer [62].…”

Section: Discussionmentioning

confidence: 99%

Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?

et al. 2022

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Background Coagulation and fibrinolysis are distinct processes that are highly correlated. Cells control coagulation and fibrinolysis by expression of tissue factor and urokinase-type plasminogen activator receptor on their surface. Tumor cells express these proteins, adjust their microenvironment and induce tumor exacerbation. We hypothesized that the expression of plasma markers for coagulation and fibrinolysis in patients with soft tissue sarcomas (STSs) was dependent on the level of tumor malignancy. To elucidate which markers are predictive of recurrence, metastasis and prognosis, coagulation or fibrinolysis, we analyzed the correlation between plasma levels of thrombin-antithrombin III complex (TAT), soluble fibrin (SF), plasmin-α2 plasmin inhibitor complex (PIC), D-dimer (DD) and clinical parameters in patients with STSs. Methods TAT, SF, PIC or DD were measured in pre-treatment blood samples from 64 patients with primary STSs and analyzed with clinicopathological parameters, and 5-year recurrence free survival (RFS), 5-year metastasis free survival (MFS) and 5-year overall survival (OS) were evaluated. Results The metastasis group had significantly higher DD (p = 0.0394), PIC (p = 0.00532) and SF (p = 0.00249) concentrations than the group without metastasis. The group that died of disease showed significantly higher DD (p = 0.00105), PIC (p = 0.000542), SF (p = 0.000126) and TAT (p = 0.0373) than surviving patients. By dividing the patients into low and high groups, the group with high DD, PIC, SF and TAT showed significantly lower 5-year MFS and 5-year OS than the corresponding low group. Furthermore, in multivariate COX proportional hazard analysis of continuous variables for 5-year MFS, only PIC was found to be a significant factor (HR: 2.14). Conclusion Fibrinolysis was better than coagulation at reflecting the disease condition of patients with STS. Notably, PIC levels ≥ 1.1 can not only predict the risk of metastasis and poor prognosis, but also increasing PIC levels correspond to further increases in risks of metastasis and poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?

et al. 2022

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“…An association between coagulation activity, INR (international normalized ratio) and cancer prognosis, such as lung cancer, colorectal cancer, pancreatic cancer, or breast cancer, has been reported [8][9][10][11][12]. Increased DD in plasma is associated with poor prognosis in cancer patients such as breast cancer, renal cell carcinoma, gastric cancer, lung cancer, bladder cancers, colorectal cancers, gynecological tumors and lymphoma [5,[13][14][15][16][17]. Among coagulation and fibrinolysis factors, DD is one of the most reported factors analyzed as a prognostic marker.…”

Section: Discussionmentioning

confidence: 99%

Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors

et al. 2021

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Background The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the malignant phenotype enhancing coagulation and fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects the expression of coagulation and fibrinolysis markers, which could be used to distinguish STS from benign soft tissue tumors. We analyzed the correlations between plasma levels of D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), and thrombin-antithrombin III complex (TAT) in benign soft tissue tumors and STS to elucidate whether these markers can be used to predict STS. Methods Plasma DD, PIC, SF and TAT levels in primary soft tissue tumors (benign 67, STS 68) were measured before biopsy or treatment. The marker levels were analyzed and compared to various clinicopathological parameters. Results In malignancy (STS), the average DD, PIC and SF levels were significantly higher than in benign tumors. Multivariate logistic analysis of continuous variables indicated that only PIC exhibited a significant difference (OR: 24.5, 95%CI: 3.55–170, p = 0.0012). Receiver operating characteristic curve analysis produced area under the curve values for DD: 0.691, PIC: 0.784, SF: 0.734 and TAT: 0.588. Youden’s index was used to establish thresholds of 0.37 (DD), 0.80 (PIC), 0.90 (SF) and 0.82 (TAT). Threshold values for PIC and SF indicated high specificity (0.881, 0.791) and high positive predictive value (0.818, 0.745), respectively. The highest accuracy value among the markers was observed for PIC (0.704). Significant differences in multivariate analysis of binary variables were demonstrated by categorizing low and high groups based on their threshold, PIC (≥0.80) (OR: 3.36, 95%CI: 1.19–9.43, p = 0.0212) and SF (≥0.90) (OR: 2.63, 95%CI: 1.04–6.66, p = 0.0404) . Conclusions Of the coagulation and fibrinolysis markers studied, increased PIC levels were related to STS and over 0.80 PIC was the most suitable for the prediction of STS, which, along with other diagnostic tools, represents a helpful subsidiary tool for the prediction of STS.

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“…Notably, the intimate relationship between coagulation and brinolysis in malignant tumors is a well-known phenomenon. Increased DD in plasma is associated with poor prognosis in cancer patients such as breast cancer, renal cell carcinoma, gastric cancer, lung cancer, bladder cancers, colorectal cancers, gynecological tumors and lymphoma 5, [5,[7][8][9][10][11]. Among coagulation and brinolysis factors, DD is one of the most reported factors analyzed as a prognostic marker.…”

Section: Discussionmentioning

confidence: 99%

Significance of Coagulation and Fibrinolysis Markers for Benign and Malignant Soft Tissue Tumors

Nakamura

Hagi

Okamoto

et al. 2020

Preprint

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Background: The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the malignant phenotype enhancing coagulation and fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects the expression of coagulation and fibrinolysis markers, which could be used to distinguish STS from benign soft tissue tumors. We analyzed the correlations between plasma levels of D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), and thrombin-antithrombin III complex (TAT) in benign soft tissue tumors and STS to elucidate whether these markers can be used to predict STS.Methods: Plasma DD, PIC, SF and TAT levels in primary soft tissue tumors (benign, 67, STS 68) were measured before biopsy or treatment. The marker levels were analyzed and compared to various clinicopathological parameters.Results: In malignancy (STS), the average DD, PIC and SF levels were significantly higher than in benign tumors. Multivariate logistic analysis of continuous variables indicated that only PIC exhibited a significant difference (OR: 24.5, 95%CI: 3.55-170, p=0.0012). Receiver operating characteristic curve analysis produced area under the curve values for DD: 0.691, PIC: 0.784, SF: 0.734 and TAT: 0.588. Youden’s index was used to establish thresholds of 0.37 (DD), 0.80 (PIC), 0.90 (SF) and 0.82 (TAT). Threshold values for PIC and SF indicated high specificity (0.881, 0.791) and high positive predictive value (0.818, 0.745), respectively The highest accuracy value among the markers was observed for PIC (0.704). Significant differences in multivariate analysis of binary variables were demonstrated by categorizing low and high groups based on their threshold, PIC (≥0.80) (OR: 3.36, 95%CI: 1.19-9.43, p=0.0212) and SF (≥0.90) (OR: 2.63, 95%CI: 1.04-6.66, p=0.0404) . Conclusions: Of the coagulation and fibrinolysis markers studied, increased PIC levels were related to STS and over 0.80 PIC was the most suitable for the prediction of STS, which, along with other diagnostic tools, represents a helpful subsidiary tool for the prediction of STS.

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D-Dimer level was associated with prognosis in metastatic colorectal cancer

Cited by 21 publications

References 29 publications

Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?

Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?

Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors

Significance of Coagulation and Fibrinolysis Markers for Benign and Malignant Soft Tissue Tumors

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