D. H. Lawrence and ‘Difference’

Chaudhuri, Amit

doi:10.1093/acprof:oso/9780199260522.001.0001

Cited by 76 publications

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“…The mechanism that is best supported by experiments is one that attributes contractility to the nonlinear, asymmetric mechanics of actin filaments. Actin filaments readily buckle under compression 145,146 whereas they strongly resist stretching 147 . Experimentally, buckling of actin filaments was observed during contraction of quasi-2D actin-myosin networks and a correlation was observed between the macroscopic deformation and the amount of deformation of individual filaments 41,148 .…”

Section: Myosin Molecular Motorsmentioning

confidence: 99%

Force percolation of contractile active gels

et al. 2017

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Living systems provide a paradigmatic example of active soft matter. Cells and tissues comprise viscoelastic materials that exert forces and can actively change shape. This strikingly autonomous behavior is powered by the cytoskeleton, an active gel of semiflexible filaments, crosslinks, and molecular motors inside cells. Although individual motors are only a few nm in size and exert minute forces of a few pN, cells spatially integrate the activity of an ensemble of motors to produce larger contractile forces (∼nN and greater) on cellular, tissue, and organismal length scales. Here we review experimental and theoretical studies on contractile active gels composed of actin filaments and myosin motors. Unlike other active soft matter systems, which tend to form ordered patterns, actin-myosin systems exhibit a generic tendency to contract. Experimental studies of reconstituted actin-myosin model systems have long suggested that a mechanical interplay between motor activity and the network's connectivity governs this contractile behavior. Recent theoretical models indicate that this interplay can be understood in terms of percolation models, extended to include effects of motor activity on the network connectivity. Based on concepts from percolation theory, we propose a state diagram that unites a large body of experimental observations. This framework provides valuable insights into the mechanisms that drive cellular shape changes and also provides design principles for synthetic active materials.

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Section: Myosin Molecular Motorsmentioning

confidence: 99%

Force percolation of contractile active gels

et al. 2017

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D. H. Lawrence

Laird¹

2014

A Companion to Modernist Poetry

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In presenting this thesis in partial fulfilment of the requirements for a Postgraduate degree from the University of Saskatchewan, I agree that the Libraries of this University may make it freely available for inspection. I further agree that permission for copying of this thesis in any manner, in whole or in part, for scholarly purposes may be granted by the professor or professors who supervised my thesis work or, in their absence, by the Head of the Department or the Dean of the College in which my thesis work was done. It is understood that any copying or publication or use of this thesis or parts thereof for financial gain shall not be allowed without my written permission. It is also understood that due recognition shall be given to me and to the University of Saskatchewan in any scholarly use which may be made of any material in my thesis.

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Where Agni Araflammed and Shiva Slew: Joyce's Interface with India

Sen¹

2017

A Companion to James Joyce

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D. H. Lawrence and ‘Difference’

Cited by 76 publications

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Force percolation of contractile active gels

Force percolation of contractile active gels

D. H. Lawrence

Where Agni Araflammed and Shiva Slew: Joyce's Interface with India

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