2012
DOI: 10.1016/j.jhep.2012.04.033
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D-livering the message: The importance of vitamin D status in chronic liver disease

Abstract: Vitamin D is synthesized predominantly in the liver and functions as an important secosteroid hormone with pleiotropic effects. While its key regulatory role in calcium and bone homeostasis is well established, recently there is increasing recognition that vitamin D also regulates cell proliferation and differentiation, and has immunomodulatory, anti-inflammatory and anti-fibrotic properties. These non-skeletal effects are relevant in the pathogenesis and treatment of many causes of chronic liver disease. Vita… Show more

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Cited by 202 publications
(193 citation statements)
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References 142 publications
(229 reference statements)
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“…Some of the major effects of optimized VD levels post transplantation include the decreased incidence of acute cellular rejection, decreased rate of infection, and reduced incidence of fracture (Kitson & Roberts, 2012;Moromizato et al, 2014;Nakchbandi, 2014). Vitamin D supplementation using ergocalciferol was the current approach at project site among liver transplant providers.…”
Section: Resultsmentioning
confidence: 99%
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“…Some of the major effects of optimized VD levels post transplantation include the decreased incidence of acute cellular rejection, decreased rate of infection, and reduced incidence of fracture (Kitson & Roberts, 2012;Moromizato et al, 2014;Nakchbandi, 2014). Vitamin D supplementation using ergocalciferol was the current approach at project site among liver transplant providers.…”
Section: Resultsmentioning
confidence: 99%
“…The intention is to supplement these patients who are especially at risk for complications of the VDD. The pre-transplant population has advanced disease, and the post population is vulnerable to infections and graft rejection (Kitson & Roberts, 2012).…”
Section: Local Issue Of Vitamin D Deficiencymentioning
confidence: 99%
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