D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway

Luo, Jialiang; Li, Yao; Zhai, Yumeng; Liu, Yao; Zeng, Junxiang; Wang, Di; Li, Lei; Zhu, Zhengyumeng; Chang, Bo Yoon; Deng, Fan; Zhang, Jing; Zhou, Jia; Sun, Lichang

doi:10.1016/j.intimp.2022.109378

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…D-mannose inhibited the TNF-α-induced increase in inflammatory cytokine expression and substantially downregulated the TNF-α-induced activation of the mTOR/NF-κB signaling pathway. This finding is the first indication that D-mannose plays a role in local skin inflammation, suggesting its potential use in treating AD (Luo et al, 2022). Psoriasis is a chronic autoimmune inflammatory skin condition with a yet-to-be-determined pathogenesis, posing significant treatment challenges.…”

Section: Role Of Mannose Metabolism In Inflammatory Diseasesmentioning

confidence: 76%

“…Mannose is linked to atopic dermatitis (AD), a chronic inflammatory disease with recurrent pruritus. In a mouse model of AD induced by DNCB (2,4-dinitrochlorobenzene), D-mannose substantially reduced skin damage and restored skin barrier function (Luo et al, 2022). D-mannose inhibited the TNF-α-induced increase in inflammatory cytokine expression and substantially downregulated the TNF-α-induced activation of the mTOR/NF-κB signaling pathway.…”

Section: Role Of Mannose Metabolism In Inflammatory Diseasesmentioning

confidence: 99%

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Mannose metabolism and immune regulation: Insights into its therapeutic potential in immunology-related diseases

BU,

LI,

XIA

et al. 2023

BIOCELL

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Mannose, a different isomer of the hydroxyl group at the C-2 position of glucose, shares the same transport carrier protein with glucose to enter cells and participate in the regulation of glucose metabolism. It affects cell growth, differentiation, and function and plays an active role in tumor immunity and inflammatory processes. This paper provides theoretical support for expanding the clinical applications of mannose by exploring its constitution, metabolic pathways, and role in regulating immune cell function and treating immunology-related diseases.

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Section: Role Of Mannose Metabolism In Inflammatory Diseasesmentioning

confidence: 76%

Section: Role Of Mannose Metabolism In Inflammatory Diseasesmentioning

confidence: 99%

Mannose metabolism and immune regulation: Insights into its therapeutic potential in immunology-related diseases

BU,

LI,

XIA

et al. 2023

BIOCELL

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“…Caspases (particularly caspase-3) are mediators of the signalling pathways for apoptosis and cell breakdown and play a role in chromatin condensation and DNA degradation during apoptosis [ 52 , 53 ]. TNF-α acts as a signalling molecule in the inflammatory response [ 54 ]. Increased levels of CASP-3 and TNF-α were observed in this study, which is in agreement with a previous study that APAP-induced inflammation in HepG2 Cells [ 55 ], suggesting that TNF-α and IL-17 signalling pathways were significantly enhanced by LPS treatment, based on findings from transcriptome analysis, which may be associated with cellular inflammatory and immune processes [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Palm Kernel Cake Extracts Obtained from the Combination of Bacterial Fermentation and Enzymic Hydrolysis Promote Swine Small Intestine IPEC-J2 Cell Proliferation and Alleviate LPS-Induced Inflammation In Vitro

Zeng,

Miao,

Liao

et al. 2024

Antioxidants

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Co-fermentation with bacteria and enzymes can reduce sugar content in palm kernel cake (PKC); however, the chemical changes and their effects on cell functionality are unclear. This study investigated the active components in pre-treated PKC extracts and their effects on pig small intestine IPEC-J2 cell proliferation and LPS-induced inflammation. The extracts contained 60.75% sugar, 36.80% mannose, 1.75% polyphenols and 0.59% flavone, as determined by chemical analyses, suggesting that the extracts were palm kernel cake oligosaccharides (PKCOS). Then, we found that 1000 µg/mL PKCOS counteracted the decrease in cell viability (CCK8 kit) caused by LPS induction by 5 µg/mL LPS (p < 0.05). Mechanistic studies conducted by RNA-seq and qPCR analyses suggested PKCOS promoted cell proliferation through the upregulation of TNF-α, PI3KAP1, MAP3K5 and Fos in the PI3K/MAPK signalling pathway; alleviated inflammation caused by LPS via the downregulation of the target genes Casp3 and TNF-α in association with apoptosis; and regulated the expression of the antioxidant genes SOD1, SOD2 and GPX4 to exert positive antioxidant effects (p < 0.05). Furthermore, PKCOS upregulated SLC5A1 (encoding SLGT1), HK and MPI in the glycolytic pathway (p < 0.05), suggesting cell survival. In summary, PKCOS has positive effects on promoting swine intestine cell proliferation against inflammation.

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Mannose: a potential saccharide candidate in disease management

et al. 2023

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D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway

Cited by 7 publications

References 41 publications

Mannose metabolism and immune regulation: Insights into its therapeutic potential in immunology-related diseases

Mannose metabolism and immune regulation: Insights into its therapeutic potential in immunology-related diseases

Palm Kernel Cake Extracts Obtained from the Combination of Bacterial Fermentation and Enzymic Hydrolysis Promote Swine Small Intestine IPEC-J2 Cell Proliferation and Alleviate LPS-Induced Inflammation In Vitro

Mannose: a potential saccharide candidate in disease management

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