d-Serine in the aging hippocampus

Billard, Jean‐Marie

doi:10.1016/j.jpba.2015.02.013

Cited by 34 publications

(29 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serine racemase synthesizes D-serine in neurons and astrocytes, while the enzyme D-amino-acid oxidase catalyzes the oxidative deamination of D-serine 29,30 (Figure 4a). We measured the gene expression of molecules involved in the production and degradation of D-serine as well as the subunits that make up NMDARs.…”

Section: Resultsmentioning

confidence: 99%

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

et al. 2017

View full text Add to dashboard Cite

Paternal environmental perturbations including exposure to drugs of abuse can produce profound effects on the physiology and behavior of offspring via epigenetic modifications. Here we show that adult drug-naive male offspring of cocaine-exposed sires have memory formation deficits and associated reductions in NMDA receptor-mediated hippocampal synaptic plasticity. Reduced levels of the endogenous NMDA receptor co-agonist D-serine were accompanied by increased expression of the D-serine degrading enzyme d-amino acid oxidase (Dao1) in the hippocampus of cocaine-sired male progeny. Increased Dao1 transcription was associated with enrichment of permissive epigenetic marks on histone proteins in the hippocampus of male cocaine-sired progeny, some of which were enhanced near the Dao1 locus. Finally, hippocampal administration of D-serine reversed both the memory formation and synaptic plasticity deficits. Collectively, these results demonstrate that paternal cocaine exposure produces epigenetic remodeling in the hippocampus leading to NMDA receptor-dependent memory formation and synaptic plasticity impairments only in male progeny, which has significant implications for the male descendants of chronic cocaine users.

show abstract

Section: Resultsmentioning

confidence: 99%

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In vivo , L-serine is produced by the serine racemase compound D-serine. D-serine is the main endogenous co-agonist of NMDAR and is required for the expression of the synaptic plasticity involved in memory [50]. Overall, the metabolic responses affecting cognition of APP/PS1 mice following CUMS included systematic changes in sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice

Han

Wang

Geng³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Stress response is determined by the brain, and the brain is a sensitive target for stress. Our previous experiments have confirmed that once the stress response is beyond the tolerable limit of the brain, particularly that of the hippocampus, it will have deleterious effects on hippocampal structure and function; however, the metabolic mechanisms for this are not well understood. Methods: Here, we used morris water maze, elisa and gas chromatography-time of flight/mass spectrometry to observe the changes in cognition, neuropathology and metabolomics in the hippocampus of APP/PS1 mice and wild-type (C57) mice caused by chronic unpredictable mild stress (CUMS), we also further explored the correlation between cognition and metabolomics. Results: We found that 4 weeks of CUMS aggravated cognitive impairment and increased amyloid-β deposition in APP/PS1 mice, but did not affect C57 mice. Under non-stress conditions, compared with C57 mice, there were 8 different metabolites in APP/PS1 mice. However, following CUMS, 3 different metabolites were changed compared with untreated C57 mice. Compared to APP/PS1 mice, there were 7 different metabolites in APP/PS1+CUMS mice. Among these alterations, 3-hydroxybutyric acid, valine, serine, beta-alanine and o-phosphorylethanolamine, which are involved in sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism. Conclusion: The results indicate that APP/PS1 mice are more vulnerable to stress than C57 mice, and the metabolic mechanisms of stress-related cognitive impairment in APP/PS1 mice are related to multiple pathways and networks, including sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism.

show abstract

“…In the recent years, d -serine in the brain has been the subject of extensive research (Fuchs et al 2005, 2011; Nunes et al 2012; Billard 2015; Sacchi et al 2016). d -Serine is an important amino acid in glutamatergic transmission (Fuchs et al 2005) and is a potent coagonist at NMDA receptors in some mammalian brain areas and possibly involved in the pathogenesis of several psychiatric and neurological disorders, such as schizophrenia (Labrie et al 2008; Nunes et al 2012; Balu and Coyle 2015; Ozeki et al 2016), bipolar disorder (Yamada et al 2004; Young and Barrett 2015), depression (Hashimoto et al 2015, 2016; Deutschenbaur et al 2016), Alzheimer’s disease (Paula-Lima et al 2013; Madeira et al 2015), and addiction (D’Ascenzo et al 2014; Seif et al 2015; Liu et al 2016).…”

Section: D-serinementioning

confidence: 99%

Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

Zheng

Wang²,

et al. 2016

Amino Acids

View full text Add to dashboard Cite

A review of studies on the body fluid levels of neuroactive amino acids, including glutamate, glutamine, taurine, gamma-aminobutyric acid (GABA), glycine, tryptophan, d-serine, and others, in autism spectrum disorders (ASD) is given. The results reported in the literature are generally inconclusive and contradictory, but there has been considerable variation among the previous studies in terms of factors such as age, gender, number of subjects, intelligence quotient, and psychoactive medication being taken. Future studies should include simultaneous analyses of a large number of amino acids [including d-serine and branched-chain amino acids (BCAAs)] and standardization of the factors mentioned above. It may also be appropriate to use saliva sampling to detect amino acids in ASD patients in the future—this is noninvasive testing that can be done easily more frequently than other sampling, thus providing more dynamic monitoring.

show abstract

d-Serine in the aging hippocampus

Cited by 34 publications

References 85 publications

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice

Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

Contact Info

Product

Resources

About