D14 repeat polymorphism of the asporin gene is associated with primary osteoarthritis of the knee in a Mexican Mestizo population

González-Huerta, Norma Celia; Borgonio-Cuadra, Verónica Marusa; Zenteno, Juan Carlos; Cortés-González, Socorro; Duarte-Salazár, Carolina; Miranda‐Duarte, Antonio

doi:10.1111/1756-185x.12797

Cited by 12 publications

(22 citation statements)

References 38 publications

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“…2013 20 Iran (Asian) 100/100 32 82 86 0.16 0.41 40 91 69 0.200 0.455 Gonzalez-Huerta et al. 2015 21 Mexico (Caucasian) 93/118 123 7 56 0.661 0.038 134 6 96 0.568 0.025 …”

Section: Resultsmentioning

confidence: 99%

“…1 ). Finally, a total of ten publications 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 30 (ten case-control studies and one cohort) examined the associations between ASPN gene D14 and D13 allele polymorphism with KOA risk, including 4610 cases and 3621 controls were selected for the meta-analysis. These studies were published from 2005 to 2015.…”

Section: Resultsmentioning

confidence: 99%

“… 13 , 31 The ASPN gene lies within a gene cluster on human chromosome 9q22-9q21.3, which encodes a cartilage extracellular protein that is member of the small leucine-rich (LRR) proteoglycan family. 13 , 21 The encoded protein (Asporin) may regulate chondrogenesis by inhibiting transforming growth factor beta 1 (TGF-β) induced gene expression in cartilage. 21 Asporin possesses a unique stretch of aspartic acid residues (D-repeat) in its N-terminal region.…”

Section: Discussionmentioning

confidence: 99%

“… 13 , 21 The encoded protein (Asporin) may regulate chondrogenesis by inhibiting transforming growth factor beta 1 (TGF-β) induced gene expression in cartilage. 21 Asporin possesses a unique stretch of aspartic acid residues (D-repeat) in its N-terminal region. 32 Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have investigated the association between aspartic acid (D) repeat polymorphism of Asporin (ASPN) gene and the risk of KOA in different populations, 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 but the results are inconsistent. For instance, four studies from in Mexican, Iranian, Japanese, and Han Chinese Asian populations detect an association with KOA.…”

Section: Introductionmentioning

confidence: 99%

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Association between aspartic acid repeat polymorphism of the asporin gene and risk of knee osteoarthritis: A systematic review and meta-analysis

Sobhan

Mehdinejad

Jamaladini

et al. 2017

Acta Orthopaedica et Traumatologica Turcica

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ObjectiveStudies have assessed the association between aspartic acid (D)-repeat polymorphism in the gene encoding Asporin (ASPN) and knee osteoarthritis (KOA) risk, but the results were inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between ASPN gene D-repeat polymorphism and KOA risk.MethodsEligible studies were identified by searching several electronic databases for relevant reports published before September 2016. The pooled odds ratios (ORs) for the association between ASPN polymorphism and KOA and their corresponding 95% confidence intervals (CIs) were estimated using the random- or fixed-effect model.ResultsA total of eleven case-control studies in ten publications with 4610 KOA cases and 3621 controls were included for the ASPN D-repeat polymorphism. Overall, no significant association was detected for D14 allele carrier (D14 vs. D13: OR = 1.10, 95% CI = 0.90–1.36, p = 0.32). Meta-analysis of D14 vs. other alleles and D13 vs. other alleles showed the same pattern of KOA association as the D14 vs. D13 (OR = 1.30, 95% CI = 1.00–1.70, p = 0.06; OR = 0.93, 95% CI = 0.82–1.06, p = 0.33, respectively). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of KOA was found in the European and Asians populations (OR = 1.05, 95% CI = 0.91–1.21, p = 0.49; OR = 0.98, 95% CI = 0.78–1.23, p = 0.88, respectively).ConclusionsThe present meta-analysis suggests that the ASPN D-repeat polymorphism is not associated with an increased KOA risk. However, future large studies with gene–gene and gene–environment interactions are needed to validate these findings.Level of evidenceLevel III diagnostic study.

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“…2013 20 Iran (Asian) 100/100 32 82 86 0.16 0.41 40 91 69 0.200 0.455 Gonzalez-Huerta et al. 2015 21 Mexico (Caucasian) 93/118 123 7 56 0.661 0.038 134 6 96 0.568 0.025 …”

Section: Resultsmentioning

confidence: 99%