D2-40, combined with calretinin, WT-1, CEA, and TTF-1, an immunohistochemical panel for differentiating malignant pleural mesothelioma from lung adenocarcinoma

Esheba, Ghada E.

doi:10.1097/01.xej.0000429917.73672.9b

Egyptian Journal of Pathology

2013

DOI: 10.1097/01.xej.0000429917.73672.9b

|View full text |Cite

D2-40, combined with calretinin, WT-1, CEA, and TTF-1, an immunohistochemical panel for differentiating malignant pleural mesothelioma from lung adenocarcinoma

Ghada E. Esheba¹

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 24 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Histopathological and Immunohistochemical Study of D2-40 Expression in Malignant Pleural Mesothelioma and Metastatic Adenocarcinoma

Ibrahim¹,

Hareedy

2020

The Medical Journal of Cairo University

View full text Add to dashboard Cite

Background: Malignant pleural mesothelioma (MPM) is known to be an aggressive malignant tumor due to the difficulty of making early diagnosis and its rapid progression. Its incidence is increasing worldwide but no treatment plans are accepted. D2-40 is an immunohistochemical marker (monoclonal antibody) that has been used as a lymphatic endothelial marker and used in the differential diagnosis of MPM (epithelioid type) versus metastatic adenocarcinoma. Fifty specimens of the pleural biopsy were viewed. They were diagnosed as 40 cases of MPM (epithelioid type) and 10 cases of metastatic adenocarcinoma (unknown primary origin). These diagnoses based on Hematoxylin and Eosin (Hx & E) stained sections and other immunohistochemical markers such as calretinin, carcinoembryonic antigen (CEA), thyroid transcription factor-1 (TTF-1). Aim of Study: To compare D2-40 immunostaining in MPM (epithelioid type) and metastatic adenocarcinoma with determining its sensitivity and specificity in both types. Results: All cases of MPM epithelioid type were positive for D2-40 while all cases of metastatic adenocarcinoma were negative (both sensitivity and specificity= 100%). D2-40 staining result was considered positive or negative according to the presence or absence of membranous staining. Statistical analysis was done for assessment of D2-40 expression in both types of tumors by using SPSS version 21. Conclusion: Routine immunohistochemical work using D2-40 with calretinin is recommended. D2-40 would be superior to calretinin because of its membranous pattern of staining which does not obscure the cytological features of the tumor cells as compared to calretinin.

show abstract

Histopathological and Immunohistochemical Study of D2-40 Expression in Malignant Pleural Mesothelioma and Metastatic Adenocarcinoma

Ibrahim¹,

Hareedy

2020

The Medical Journal of Cairo University

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

D2-40, combined with calretinin, WT-1, CEA, and TTF-1, an immunohistochemical panel for differentiating malignant pleural mesothelioma from lung adenocarcinoma

Cited by 1 publication

References 24 publications

Histopathological and Immunohistochemical Study of D2-40 Expression in Malignant Pleural Mesothelioma and Metastatic Adenocarcinoma

Histopathological and Immunohistochemical Study of D2-40 Expression in Malignant Pleural Mesothelioma and Metastatic Adenocarcinoma

Contact Info

Product

Resources

About