D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity

Nisoli, Enzo; Brunani, Amelia; Borgomainerio, E.; Tonello, Cristina; Dioni, Laura; Briscini, Luca; Redaelli, Gabriella; Molinari, Enrico; Cavagnini, F.; Carruba, Michele O.

doi:10.1007/bf03327583

Cited by 68 publications

(52 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[327] compared neural responses to food-reward outcomes in individuals with BN and with anorexia nervosa (AN), and found that individuals with BN had relatively greater activation in the dorsolateral prefrontal cortex, the insular cortex, and the pre-central gyrus. These studies compliment candidate genetic behavior investigations in BN that have reported altered allelic frequencies for the DAT gene [328] and DA receptor genes [329,330] in individuals with bulimia.…”

Section: Reviewsupporting

confidence: 74%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

View full text Add to dashboard Cite

This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

show abstract

Section: Reviewsupporting

confidence: 74%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

View full text Add to dashboard Cite

show abstract

“…The presence of the A1 allele is not reported to be related to body weight (Nisoli et al, 2007), which was also indicated in our study. In addition, the Taq1A polymorphism is unlikely to be a common cause of obesity in Nauruan and Australian subjects (Southon et al, 2003).…”

Section: Ergun Et Alsupporting

confidence: 79%

The Apolipoprotein E Gene and Taq1A Polymorphisms in Childhood Obesity

Ergün

Karaoğuz

Koç

et al. 2010

Genetic Testing and Molecular Biomarkers

View full text Add to dashboard Cite

“…Gambling Comings et al1996 Methamphetamine Chen et al 2004 Polysubstance abuse Persico et al 1996 Nisoli et al 2007;Davis et al 2008 the contribution of DRD2 variants in schizophrenia has been investigated (Seeman et al 1987). A number of DRD2 polymorphisms (including the TaqIA SNP of ANKK1) have been tested for linkage and association with schizophrenia.…”

Section: Schizophreniamentioning

confidence: 98%

The ANKK1 Kinase Gene and Psychiatric Disorders

et al. 2009

View full text Add to dashboard Cite

The TaqIA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 dopamine receptor gene (DRD2; chromosome 11q22-q23), is the most studied genetic variation in a broad range of psychiatric disorders and personality traits. A large number of individual genetic association studies have found that the TaqIA SNP is linked to alcoholism and antisocial traits. In addition, it has also been related to other conditions such as schizophrenia, eating disorders, and some behavioral childhood disorders. The TaqIA A1 allele is mainly associated with addictions, antisocial disorders, eating disorders, and attention-deficit/hyperactivity disorders, while the A2 allele occurs more frequently in schizophrenic and obsessive-compulsive patients. Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants. ANKK1 would belong to a family of kinases involved in signal transduction. This raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders. Basic research on the ANKK1 protein and its putative interaction with the D2 dopamine receptor could shed light on this issue.

show abstract

D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity

Abstract: These results confirm that the presence of A1+ allele is not simply related to body weight but the A1+ allele might be a marker of a genetic psychological condition in people with high risk to develop pathological eating behaviour.

Cited by 68 publications

References 36 publications

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

The Apolipoprotein E Gene and Taq1A Polymorphisms in Childhood Obesity

The ANKK1 Kinase Gene and Psychiatric Disorders

Contact Info

Product

Resources

About