D3 receptor agonist efficacy in restless legs syndrome

Galbiati, Andrea; Ferini‐Strambi, Luigi

doi:10.1016/bs.apha.2019.01.005

Cited by 3 publications

(4 citation statements)

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“…In addition, dopamine alterations may result in attentional and learning deficits ( 54–56 ), which could be explained by the reduced functional connectivity between the striatum and the frontoparietal networks and increased striatal functional connectivity with the limbic network in NF1 children ( 57 ). Specifically, the dopaminergic pathway alteration can indeed cause the higher PLMI in NF1 reported in our study considering that periodic limb movement disorder and the restless leg syndrome tend usually to beneficiate from dopaminergic receptor agonists treatment ( 58 , 59 ) or iron supplementation in developmental age ( 60 ) due to functional interactions among iron, epicidin, and dopamine production ( 18 ).…”

Section: Discussionmentioning

confidence: 67%

Polysomnographic study in pediatric neurofibromatosis type 1

et al. 2023

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BackgroundNeurofibromatosis type 1 (NF1) is a genetic disease that alters neurodevelopment. We aimed to analyze the sleep macrostructure of a sample of children affected by NF1 without neurocognitive co-morbidities and MRI reports of unidentified bright objects (UBOs).MethodsA 100 pre-pubertal children participated in the cross-sectional study: 50 subjects were children diagnosed with NF1 and 50 subjects were typically developing healthy children (TDC). All participants underwent polysomnographic evaluation through which conventional sleep parameters were collected: Total sleep time (TST), Sleep latency (SOL), first REM latency (FRL), number of stage shifts/h (SS/h), number of awakenings/h (AWN/h), wake after sleep onset (WASO%), sleep efficiency percentage (SE%), percentage of sleep time spent in sleep stages 1 (N1%) and 2 (N2%), slow-wave sleep (N3%), and REM sleep (REM%). Additionally, nocturnal respiratory events such as apnea/hypopnea index (AHI), oxygen desaturation index (ODI), and periodic limb movement index (PLMI) were recorded.ResultsNeurofibromatosis type 1 children showed a reduction in sleep duration parameters (TST; p < 0.001), sleep efficiency (SE%; p < 0.001), and stage N2% (p < 0.001). Moreover, the number of awakenings per hour (AWN/h), wake after sleep onset (WASO%), and respiratory events such as AHI, ODI, and PLMI resulted higher in NF1 vs. TDC children.ConclusionThe data showed that the sleep macrostructure differs between NF1 and TDC children. These findings suggest that the evaluation of sleep may provide useful support in corroborating the diagnosis and offers additional therapeutic management perspectives in NF1 and genetic neurodevelopmental disorders in general.

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Section: Discussionmentioning

confidence: 67%

Polysomnographic study in pediatric neurofibromatosis type 1

et al. 2023

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“…С помощью патоморфологических методов, а также методов визуализации выявлена гиперактивность дофаминергической системы в базальных ганглиях: повышенное содержание дофамина и его фосфорилированной формы обнаруживалось в черной субстанции и скорлупе. По-видимому, это обусловлено увеличением экспрессии тирозингидроксилазы в базальных ганглиях вследствие гипоксии [31]. В ответ на повышение продукции внеклеточного дофамина происходит снижение экспрессии рецепторов D1 и D2, снижается их плотность на мембранах клеток в хвостатом ядре и скорлупе [31].…”

Section: общая характеристика синдрома беспокойных ногunclassified

“…По-видимому, это обусловлено увеличением экспрессии тирозингидроксилазы в базальных ганглиях вследствие гипоксии [31]. В ответ на повышение продукции внеклеточного дофамина происходит снижение экспрессии рецепторов D1 и D2, снижается их плотность на мембранах клеток в хвостатом ядре и скорлупе [31]. В сочетании с циркадианными особенностями метаболизма дофамина (повышение в дневное…”

Section: общая характеристика синдрома беспокойных ногunclassified

“…Нервно-мышечные Б О Л Е З Н И Neuromuscular DISEASES 4'2022 ТОМ 12 VOL. 12 время и снижение в ночное) в ночное время суток возникает относительный дефицит дофамина, что приводит к возникновению симптомов СБН [31,32]. Процесс формирования миелиновой оболочки также зависит от железа.…”

Section: лекции и обзоры | Lectures and Reviewsunclassified

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Anemia in patients with inflammatory bowel disease as a risk factor for restless legs syndrome. Literature review

Zakharova

Калинкин

2022

Neuromuscular Diseases

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Restless legs syndrome (RLS) is a neurological, sensorimotor disorder. It is characterized by the uncomfortable and unpleasant sensations in the legs which begin or worsen during periods of rest, primarily in the evening or night, and are relieved by movement. Central iron deficiency plays a vital role in the pathogenesis of RLS. There is evidence that chronic inflammation is an additional risk factor for RLS. Anemia is the most common complication and extraintestinal manifestation of inflammatory bowel disease, therefore the prevalence of RLS in these patients is a problem of great interest. In addition, inflammatory bowel disease patients’ sleep disturbances directly influence the disease’s clinical course and can be the preclinical marker of exacerbation. It is essential for clinicians to be aware of RLS as a possible reason for sleep disturbance and as a factor that negatively affects the quality of life in inflammatory bowel disease patients.

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