2013
DOI: 10.1038/hr.2013.9
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D5 dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1

Abstract: D5 dopamine receptor (D5R) knock-out mice (D5−/−) have a higher blood pressure (BP) and higher reactive oxygen species (ROS) production than their D5R wild-type littermates (D5+/+). We tested the hypothesis that the high BP and increased ROS production in D5−/− mice may be caused by decreased heme oxygenase-1 (HO-1) expression and activity. We found that renal HO-1 protein expression and HO enzyme activity were decreased (65 and 50%, respectively) in D5−/− relative to D5+/+ mice. A 24 h of administration of he… Show more

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Cited by 28 publications
(47 citation statements)
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“…The ability of D 5 R to inhibit NOX2 expression in the long-term is in agreement with our previous report that the long-term antioxidant effect of D 5 R was related, in part, to inhibition to NOX2 expression [52]. However, the inhibitory effect of D 5 R on NOX activity was not completely abolished by PON2 -siRNA, which could be attributed to the partial gene silencing effect of PON2 -siRNA, or the contribution of other anti-oxidative mechanisms, such as HO-1 [56]. …”
Section: Discussionsupporting
confidence: 91%
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“…The ability of D 5 R to inhibit NOX2 expression in the long-term is in agreement with our previous report that the long-term antioxidant effect of D 5 R was related, in part, to inhibition to NOX2 expression [52]. However, the inhibitory effect of D 5 R on NOX activity was not completely abolished by PON2 -siRNA, which could be attributed to the partial gene silencing effect of PON2 -siRNA, or the contribution of other anti-oxidative mechanisms, such as HO-1 [56]. …”
Section: Discussionsupporting
confidence: 91%
“…Thus, PON2 -siRNA partially reversed the inhibitory effect of fenoldopam on NOX activity by 63.3%. However, PON2 -siRNA did not completely abolish the inhibitory effect of long-term (24 h) fenoldopam treatment on NOX activity, which may be attributed to other D 5 R-mediated antioxidant mechanisms, such as stimulation of HO-1 [56] and inhibition of PLD2 [51,52]. …”
Section: Resultsmentioning
confidence: 99%
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“…ROS production is limited not only by decreased oxidant activity, but also by increased antioxidant defense [10, 14]. Peroxiredoxins are thiol-based antioxidant enzymes detoxifying ROS by oxidation of their two cysteine groups to cysteine sulfinic acid (Cys-SO 2 H) or cysteine sulfonic acid (Cys-SO 3 H), causing inactivation of peroxidase activity [1619].…”
Section: Introductionmentioning
confidence: 99%