D6: Gastric Acid Response to Distension of the Stomach in Man

Bergegårdh, S; Olbe, L

doi:10.1111/j.1748-1716.1971.tb05011.x

Cited by 11 publications

(8 citation statements)

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“…The most likely explanation for the postweaning rise of plasma gastrin may be that the stomach was never empty in weaned calves. Gastrin release is indeed triggered by the presence of (protein) nutrients in the lumen, and by antrum (Bergegardh and Olbe, 1975;Debas et al, 1975) and fundus (Grotzinger et al, 1977) distension. Moreover, G cells may be more responsive to solid than to liquid food (Hirschowitz, 1983).…”

Section: Data)mentioning

confidence: 99%

Plasma and tissue levels of digestive regulatory peptides during postnatal development and weaning in the calf

Guilloteau¹,

Huërou-Luron²,

Ja³

et al. 1992

Reprod. Nutr. Dev.

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Summary ― Changes in the concentrations of cholecystokinin, gastric inhibitory peptide, gastrin, motilin, pancreatic polypeptide, secretin, somatostatin, and vasoactive intestinal peptide in calf plasma and antral, duodenal and/or pancreatic tissues were assessed by radioimmunoassay during postnatal development and after weaning in 50 male Holstein-Friesian calves (randomly distributed into 10 groups of 5 animals each). The calves in the first group were killed at birth while those in 6 other groups were colostrum-fed for 2 days and then milk-fed until 7, 28, 56, 70

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Section: Data)mentioning

confidence: 99%

Plasma and tissue levels of digestive regulatory peptides during postnatal development and weaning in the calf

Guilloteau¹,

Huërou-Luron²,

Ja³

et al. 1992

Reprod. Nutr. Dev.

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“…In 5 healthy subjects the antrum was distended with 150 ml for 1 h and in 7 healthy subjects this was performed during submaximal stimu lation of the acid secretion by a pentagastrin infusion (peptavlon, ICI, UK) 16 or 90 ug/h; the individual dose of pentagastrin giving submaximal (>50 and <100% of peak acid output) was previously deter mined. The method for graded distention of the antrum in man and the effect on acid secretion has been described in detail elsewhere (2,3). A thin-walled balloon attached to a nasogastric tube was placed in the antrum.…”

Section: Antrai Distentionmentioning

confidence: 99%

Vagovagal Stimulation of Pancreatic-Polypeptide Secretion by Graded Distention of the Gastric Fundus and Antrum in Man

Schwartz¹,

Grötzinger²,

Schöön³

et al. 1979

Digestion

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Previous studies have shown that pancreatic polypeptide (PP) secretion is regulated by efferent, vagal stimulation. In the present study the afferent part of a vagovagal pathway has been investigated in two different ways: (I) Graded fundic distention: in 8 patients with duodenal ulcer ballon distention with 150 ml of the fundus and the body of the stomach increased PP concentrations in plasma from 19 (17–26) to 41 (35–48) pmol/l, median and interquartile range. Distention by 300 and 600 ml did not further increase PP concentrations. After denervation of the fundus by proximal gastric vagotomy, no increase in PP levels was observed during distention with 50 and 300 ml whereas distention by 600 ml was followed by a small increase. (II) Graded antral distention: balloon distention with 50, 100 and 150 ml of the antrum increased plasma PP concentrations in 7 healthy subjects and 14 duodenal ulcer patients. Maximal PP response was achieved by distention with 100 ml, healthy subjects: from 14 (12–23) to 40 (26–44) pmol/l, and duodenal ulcer patients: from 25 (13–38) to 47 (22–63) pmol/l, median and interquartile range. It is concluded that a gastropancreatic reflex stimulating PP secretion through a long vagovagal pathway is present in man, and that this mechanism probably is involved in the initial PP response during a meal.

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“…The effect is stimulatory in duodenal ulcer patients (4 -6 ) and inhibitory in healthy subjects (4,17). The inhibitory mechanism seems to be defective in duodenal ulcer patients (17) and might therefore be of both physiologi cal and pathophysiological interest.…”

Section: Discussionmentioning

confidence: 99%

“…Exclusive antral distension has been used since fundic distension stimulates acid secretion in both healthy sub jects and duodenal ulcer patients (10). The maximal volume of the balloon for exclusive antral distension is 150 ml (4).…”

Section: Discussionmentioning

confidence: 99%

“…The inhibitory mechanism seems to be defective in duodenal ulcer patients (17) and might therefore be of both physiologi cal and pathophysiological interest. The antral distension has been performed with a balloon, the filling of which never generated pressures exceeding 15-20 cm water (4). Exclusive antral distension has been used since fundic distension stimulates acid secretion in both healthy sub jects and duodenal ulcer patients (10).…”

Section: Discussionmentioning

confidence: 99%

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A Study of the Effect of Antral Distension on Gastric Acid Secretion in Man

Schöön¹,

Lundqvist²,

Rehfeld³

et al. 1981

Digestion

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In 30 healthy subjects distension of the antrum by a 150-cm³ balloon reduced the acid and volume responses to submaximal stimulation achieved by a continuous intravenous infusion of pentagastrin. The inhibition persisted during perfusion of the stomach with alkaline buffer. The plasma somatostatin concentration did not increase during distension and no somatostatin was detected in the gastric contents. Balloon distension of the antrum during laparotomy did not affect the concentration of somatostatin and gastrin in portal blood in patients with gallbladder disease or duodenal ulcer. The results confirm that antral distension stimulates acid secretion in duodenal ulcer patients without involvement of the gastrin mechanism. Moreover, the inhibition of acid secretion by antral distension in healthy subjects is independent of luminal pH and does not appear to be mediated by somatostatin.

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D6: Gastric Acid Response to Distension of the Stomach in Man

Cited by 11 publications

References 0 publications

Plasma and tissue levels of digestive regulatory peptides during postnatal development and weaning in the calf

Plasma and tissue levels of digestive regulatory peptides during postnatal development and weaning in the calf

Vagovagal Stimulation of Pancreatic-Polypeptide Secretion by Graded Distention of the Gastric Fundus and Antrum in Man

A Study of the Effect of Antral Distension on Gastric Acid Secretion in Man

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