Daily Adaptive Radiotherapy Using the Varian ETHOS System to Improve Dose Distribution During Treatment to the Upper Abdomen

Ward, A.; Martinou, M.; Kidane, G.; Graham, S.

doi:10.1016/j.clon.2022.01.036

Cited by 4 publications

(2 citation statements)

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“…Although the majority of adaptive treatments happen for pelvic RT treatments due to large and stochastic variations in anatomy, ETHOS has been used for other tumour locations, such as pancreatic and lower oesophagus cancers [11] , [12] . To our knowledge, this is the first case of online-ART treatment for a colon cancer.…”

Section: Discussionmentioning

confidence: 99%

Cone-beam computed tomography-guided online-adaptive radiotherapy for inoperable right colon cancer: First in human

Pierrard,

Dumont,

Dechambre

et al. 2023

Technical Innovations & Patient Support in Radiation Oncolo

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Section: Discussionmentioning

confidence: 99%

Cone-beam computed tomography-guided online-adaptive radiotherapy for inoperable right colon cancer: First in human

Pierrard,

Dumont,

Dechambre

et al. 2023

Technical Innovations & Patient Support in Radiation Oncolo

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“…The attending physician then reviews the quality of both plans before deciding which to use for treatment. Numerus studies have demonstrated the feasibility of utilization of the Ethos system for ART for different cancer sites with real patient cases or emulation studies following the standard adaptive workflow [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. The goal of this study is to test our novel workflow, in which the required individually optimized preplan is replaced by a properly selected plan from a pre-built plan library.…”

Section: Introductionmentioning

confidence: 99%

Simulation and pre-planning omitted radiotherapy (SPORT): a feasibility study for prostate cancer

Zhuang,

Parsons,

Desai

et al. 2024

Biomed. Phys. Eng. Express

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This study explored the feasibility of on-couch intensity modulated radiotherapy (IMRT) planning for prostate cancer (PCa) on a cone-beam CT (CBCT)-based online adaptive RT platform without an individualized pre-treatment plan and contours. Ten patients with PCa previously treated with image-guided IMRT (60Gy/20 fractions) were selected. In contrast to the routine online adaptive RT workflow, a novel approach was employed in which the same preplan that was optimized on one reference patient was adapted to generate individual on-couch/initial plans for the other nine test patients using Ethos emulator. Simulation CTs of the test patients were used as simulated online CBCT (sCBCT) for emulation. Quality assessments were conducted on synthetic CTs (sCT). Dosimetric comparisons were performed between on-couch plans, on-couch plans recomputed on the sCBCT and individually optimized plans for test patients. The median value of mean absolute difference between sCT and sCBCT was 74.7 HU (range 69.5-91.5 HU). The average CTV/PTV coverage by prescription dose was 100.0%/94.7%, and normal tissue constraints were met for the nine test patients in on-couch plans on sCT. Recalculating on-couch plans on the sCBCT showed about 0.7% reduction of PTV coverage and a 0.6% increasing of hotspot, and the dose difference of the OARs was negligible (<0.5 Gy). Hence, initial IMRT plans for new patients can be generated by adapting a reference patient’s preplan with online contours, which had similar qualities to the conventional approach of individually optimized plan on the simulation CT. Further study is needed to identify selection criteria for patient anatomy most amenable to this workflow.

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Cone-Beam Computed Tomography‑Guided Online Adaptive Radiotherapy for Inoperable Right Colon Cancer: First in Human

Pierrard

Dumont

Dechambre

et al. 2023

Preprint

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Daily Adaptive Radiotherapy Using the Varian ETHOS System to Improve Dose Distribution During Treatment to the Upper Abdomen

Cited by 4 publications

References 0 publications

Cone-beam computed tomography-guided online-adaptive radiotherapy for inoperable right colon cancer: First in human

Cone-beam computed tomography-guided online-adaptive radiotherapy for inoperable right colon cancer: First in human

Simulation and pre-planning omitted radiotherapy (SPORT): a feasibility study for prostate cancer

Cone-Beam Computed Tomography‑Guided Online Adaptive Radiotherapy for Inoperable Right Colon Cancer: First in Human

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