Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice

László, J.; Szilvási, Judit; Fényi, Anett; Szalai, Andrea; Gyires, Klára; Pórszász, Robert

doi:10.3109/09553002.2010.518200

Cited by 15 publications

(3 citation statements)

References 46 publications

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“…For mice with type 2 diabetes, glucose was significantly reduced (p<0.01) only for mice treated with 600 mT. A similar reduction trend for the resting blood glucose of STZ-induced diabetic mice was reported for mice housed in cages and exposed to nonhomogeneous fields for 30 minutes/day for six weeks [ 35 ]. The SMF-treated diabetic mice were exposed to about 477 mT at their feet and about 2.8 mT at the top of their heads.…”

Section: Reviewsupporting

confidence: 73%

Do Magnetic Fields Have a Place in Treating Vascular Complications in Diabetes?

Mayrovitz¹,

Maqsood²,

Tawakalzada³

2022

Cureus

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The use of electromagnetic field therapy (EMFT) is a non-invasive, potential alternative or complementary choice in the treatment of wounds, chronic pain, neuropathy, and other medical conditions, including tissue repair and cell proliferation. Static magnetic fields (SMFs) have been reported to increase microcirculatory blood flow by mediating vasodilation via nitric oxide. Studies report that SMF exposure causes homeostatic, normalizing effects on the vascular tone that may have beneficial effects in situations where tissue perfusion is limited, such as may be present in diabetes. Pulsed electromagnetic fields (PEMFs) have also shown promise in treating diabetic wounds by improving wound healing rates and other attributes. Our purpose was to critically review prior applications of EMFT for relevancy and effectiveness in treating diabetic complications. The goal was to provide information to allow for informed decisions on the possible use of these modalities in the treatment of persons with diabetic complications. The focus was on the following major areas: wound healing, neuropathy, blood glucose control, blood flow, inflammation and oxidative stress.

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Section: Reviewsupporting

confidence: 73%

Do Magnetic Fields Have a Place in Treating Vascular Complications in Diabetes?

Mayrovitz¹,

Maqsood²,

Tawakalzada³

2022

Cureus

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“…If in vitro evidence was found on the SMF-exposure induced inhibition or assistance of the release of pro- and anti-inflammatory cytokines, a possible background mechanism of in vivo experienced antinociceptive effects in invertebrates [18], in mice [19]–[25], and in humans [26] would be supported. Therefore, the present set of in vitro experiments was designed to prove the null-hypotheses that exposure of PBMC to an inhomogeneous SMF for up to 24 h leads to a significant change in the:…”

Section: Introductionmentioning

confidence: 99%

In Vitro Analysis of the Anti-Inflammatory Effect of Inhomogeneous Static Magnetic Field-Exposure on Human Macrophages and Lymphocytes

Vergallo

Szamosvölgyi²,

Tenuzzo

et al. 2013

PLoS ONE

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The effect of inhomogeneous static magnetic field (SMF)-exposure on the production of different cytokines from human peripheral blood mononuclear cells (PMBC), i.e., lymphocytes and macrophages, was tested in vitro. Some cultures were activated with lipopolysaccharide (LPS) at time point −3 h and were either left alone (positive control) or exposed to SMF continuously from 0 until 6, 18, or 24 h. The secretion of interleukin IL-6, IL-8, tumor necrosis factor TNF-α, and IL-10 was tested by ELISA. SMF-exposure caused visible morphological changes on macrophages as well as on lymphocytes, and also seemed to be toxic to lymphocytes ([36.58; 41.52]%, 0.308≤p≤0.444), but not to macrophages (<1.43%, p≥0.987). Analysis of concentrations showed a significantly reduced production of pro-inflammatory cytokines IL-6, IL-8, and TNF-α from macrophages compared to negative control ([56.78; 87.52]%, p = 0.031) and IL-6 compared to positive control ([45.15; 56.03]%, p = 0.035). The production of anti-inflammatory cytokine IL-10 from macrophages and from lymphocytes was enhanced compared to negative control, significantly from lymphocytes ([−183.62; −28.75]%, p = 0.042). The secretion of IL-6 from lymphocytes was significantly decreased compared to positive control ([−115.15; −26.84]%, p = 0.039). This massive in vitro evidence supports the hypotheses that SMF-exposure (i) is harmful to lymphocytes in itself, (ii) suppresses the release of pro-inflammatory cytokines IL-6, IL-8, and TNF-α, and (iii) assists the production of anti-inflammatory cytokine IL-10; thus providing a background mechanism of the earlier in vivo demonstrated anti-inflammatory effects of SMF-exposure.

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“…For example, exposure to a static electric field (7 kV/m) combined with 3 mT SMF ( Carter et al, 2020 ) and downward SMF of 100 mT ( Yu et al, 2021 ) can have positive effects on T2D mice. Furthermore, exposure to 2.8–476.7 mT heterogenous SMFs for 12 weeks can significantly alleviate hyperglycemia in STZ-induced T1D mice ( László et al, 2011 ). These studies also showed that lower SMFs (<0.5 T) can decrease ROS levels, in contrast to our findings on high-gradient SMFs.…”

Section: Discussionmentioning

confidence: 99%

Effects of gradient high-field static magnetic fields on diabetic mice

Yu¹,

Chen²,

Feng³

et al. 2023

Zoological Research

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Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety in diabetic patients is unclear. Furthermore, the effects of high static magnetic fields (SMFs), especially gradient vs. uniform fields, have not been investigated in diabetics. Here, we investigated the consequences of exposure to 1.0–9.4 T high SMFs of different gradients (>10 T/m vs. 0–10 T/m) on type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. We found that 14 h of prolonged treatment of gradient (as high as 55.5 T/m) high SMFs (1.0–8.6 T) had negative effects on T1D and T2D mice, including spleen, hepatic, and renal tissue impairment and elevated glycosylated serum protein, blood glucose, inflammation, and anxiety, while 9.4 T quasi-uniform SMFs at 0–10 T/m did not induce the same effects. In regular T1D mice (blood glucose ≥16.7 mmol/L), the >10 T/m gradient high SMFs increased malondialdehyde ( P< 0.01) and decreased superoxide dismutase ( P< 0.05). However, in the severe T1D mice (blood glucose ≥30.0 mmol/L), the >10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate. In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation. Therefore, this study showed that prolonged exposure to high-field (1.0–8.6 T) >10 T/m gradient SMFs (35–1 380 times higher than that of current clinical MRI) can have negative effects on diabetic mice, especially mice with severe T1D, whereas 9.4 T high SMFs at 0–10 T/m did not produce the same effects, providing important information for the future development and clinical application of SMFs, especially high-field MRI.

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Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice

Abstract: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucose level in diabetic mice.

Cited by 15 publications

References 46 publications

Do Magnetic Fields Have a Place in Treating Vascular Complications in Diabetes?

Do Magnetic Fields Have a Place in Treating Vascular Complications in Diabetes?

In Vitro Analysis of the Anti-Inflammatory Effect of Inhomogeneous Static Magnetic Field-Exposure on Human Macrophages and Lymphocytes

Effects of gradient high-field static magnetic fields on diabetic mice

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