Daily folate consumption is associated with reduced all-cause and cardiovascular disease mortality among US adults with diabetes, prediabetes, or insulin resistance

Liu, Wei; Cao, Shuting; Shi, Da; Ye, Zi; Yu, Linling; Liang, Ruyi; Chen, Weihong; Wang, Bin

doi:10.1016/j.nutres.2023.04.007

Cited by 6 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both insulin resistance (IR) and cardiovascular disease (CVD) are serious public health issues. IR has been proven to have an important impact on diabetes and CVD risk factors [ 16 ]. Insulin resistance develops when insulin fails to exert its full effect on target tissues.…”

Section: Discussionmentioning

confidence: 99%

The triglyceride-glucose index is associated with atherosclerosis in patients with symptomatic coronary artery disease, regardless of diabetes mellitus and hyperlipidaemia

Li,

Dong,

et al. 2023

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background Diabetes and hyperlipidaemia are both risk factors for coronary artery disease, and both are associated with a high triglyceride-glucose index (TyG index). The TyG index has been presented as a marker of insulin resistance (IR). Its utility in predicting and detecting cardiovascular disease has been reported. However, few studies have found it to be a helpful marker of atherosclerosis in patients with symptomatic coronary artery disease (CAD). The purpose of this study was to demonstrate that the TyG index can serve as a valuable marker for predicting coronary and carotid atherosclerosis in symptomatic CAD patients, regardless of diabetes mellitus and hyperlipidaemia. Methods This study included 1516 patients with symptomatic CAD who underwent both coronary artery angiography and carotid Doppler ultrasound in the Department of Cardiology at Tianjin Union Medical Center from January 2016 to December 2022. The TyG index was determined using the Ln formula. The population was further grouped and analysed according to the presence or absence of diabetes and hyperlipidaemia. The Gensini score and carotid intima-media thickness were calculated or measured, and the patients were divided into four groups according to TyG index quartile to examine the relationship between the TyG index and coronary or carotid artery lesions in symptomatic CAD patients. Results In symptomatic CAD patients, the TyG index showed a significant positive correlation with both coronary lesions and carotid plaques. After adjusting for sex, age, smoking, BMI, hypertension, diabetes, and the use of antilipemic and antidiabetic agents, the risk of developing coronary lesions and carotid plaques increased across the baseline TyG index. Compared with the lowest quartile of the TyG index, the highest quartile (quartile 4) was associated with a greater incidence of coronary heart disease [OR = 2.55 (95% CI 1.61, 4.03)] and carotid atherosclerotic plaque [OR = 2.31 (95% CI 1.27, 4.20)] (P < 0.05). Furthermore, when compared to the fasting blood glucose (FBG) or triglyceride (TG) level, the TyG index had a greater area under the ROC curve for predicting coronary lesions and carotid plaques. The subgroup analysis demonstrated the TyG index to be an equally effective predictor of coronary and carotid artery disease, regardless of diabetes and hyperlipidaemia. Conclusion The TyG index is a useful marker for predicting coronary and carotid atherosclerosis in patients with symptomatic CAD, regardless of diabetes mellitus and hyperlipidaemia. The TyG index is of higher value for the identification of both coronary and carotid atherosclerotic plaques than the FBG or TG level alone.

show abstract

Section: Discussionmentioning

confidence: 99%

The triglyceride-glucose index is associated with atherosclerosis in patients with symptomatic coronary artery disease, regardless of diabetes mellitus and hyperlipidaemia

Li,

Dong,

et al. 2023

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…36 The physical activity questionnaire involved in the study was based on the Global Physical Activity Questionnaire, including questions related to daily activities, leisure time activities, and sedentary activities, and the degree of self-reported physical activity was defined as vigorous or moderate recreational physical activity for at least 10 min per week. 37,38 The healthy eating index (HEI-2015) was calculated to assess dietary quality, as described in the literature, and individuals with a healthy eating index in the top 40% of the distribution were regarded as having a healthy diet. 39,40…”

Section: Methodsmentioning

confidence: 99%