2018
DOI: 10.1590/1678-7757-2017-0470
|View full text |Cite
|
Sign up to set email alerts
|

Daily melatonin administration improves osseointegration in pinealectomized rats

Abstract: The hypothesis of this study was that the peri-implant bone healing of the group of pinealectomized rats would differ from the control group. The samples were subjected to immunohistochemical, microtomographic (total porosity and connectivity density), and fluorochrome (mineralized surface) analyses. Objectives The goal of this study was to investigate the cellular changes and bone remodeling dynamics along the bone/implant interface in pinealectomized rats.Material and Methods The total of 18 adult male rats … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
41
0
2

Year Published

2019
2019
2021
2021

Publication Types

Select...
10

Relationship

4
6

Authors

Journals

citations
Cited by 29 publications
(44 citation statements)
references
References 32 publications
1
41
0
2
Order By: Relevance
“…The sample size was determined according to the previously published manuscript [38], in which six animals per group were used, with a normal distribution. Thus, eight animals per group (n = 8) were elected, in compliance with the ethical guidelines for animal researches that expect losses of at least 20% of the sample.…”
Section: Discussionmentioning
confidence: 99%
“…The sample size was determined according to the previously published manuscript [38], in which six animals per group were used, with a normal distribution. Thus, eight animals per group (n = 8) were elected, in compliance with the ethical guidelines for animal researches that expect losses of at least 20% of the sample.…”
Section: Discussionmentioning
confidence: 99%
“…The immunohistochemical reactions were evaluated by assigning scores based on a semi-quantitative analysis [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. The scores were assigned as null (0), mild (1), moderate (2), and intense (3).…”
Section: Methodsmentioning
confidence: 99%
“…Animal models provide relevant information about a variety of disorders in dentistry. The rat model has been widely used for studies in dentistry, including those which involve periodontal diseases, alveolar bone healing, tooth movement, osteogenesis, osseointegration, use of biomaterials, and altered occlusal loadings, for example (Okamoto and de Russo, 1973;Shimomoto et al, 2007;Walker et al, 2008;Wan et al, 2012;Xu et al, 2016;Zeng et al, 2016;Koutouzis et al, 2017;Lee et al, 2017;Hassumi et al, 2018;Palin et al, 2018;Uslu et al, 2018;Wang et al, 2018). Besides that, tooth extraction, inclosing incisor extraction, has been considered as a classical model of preclinical studies and has been applied in many studies with different aims in the last years (Avivi-Arber et al, 2010;Shoji et al, 2010;Boonyagul et al, 2014;Curra et al, 2016;Hassumi et al, 2018;de Oliveira Puttini et al, 2019).…”
Section: Discussionmentioning
confidence: 99%