Daily Variations in Skin Surface Properties Using Mixed Model Methodology

Latreille, Julie; Guinot, Christiane; Robert-Granié, Christèle; Fur, Isabelle Le; Tenenhaus, Michel; Foulley, Jean-Louis

doi:10.1159/000077240

Cited by 18 publications

(16 citation statements)

References 29 publications

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“…Various other authors have looked at the same questions, highlighting intra-and interpersonal differences. [27][28][29][30][31][32] We can therefore conclude that either more sophisticated global models or a (partial) adjustment of the model to the subject can improve the further performance of the glucose estimations with the current sensor design. Finally, key indicators in Table 1 and Table 2 show that glucose point accuracy estimated with the Multisensor system is not yet at the same level of finger prick based devices due to nonstationarities in the measured signals that are not solved by the linear model with fixed parameters.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Global, Subject, and Device-Specific Model on a Noninvasive Glucose Monitoring Multisensor System

Caduff¹,

Zanon²,

Mueller³

et al. 2015

J Diabetes Sci Technol

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Background: We study here the influence of different patients and the influence of different devices with the same patients on the signals and modeling of data from measurements from a noninvasive Multisensor glucose monitoring system in patients with type 1 diabetes. The Multisensor includes several sensors for biophysical monitoring of skin and underlying tissue integrated on a single substrate. Method: Two Multisensors were worn simultaneously, 1 on the upper left and 1 on the upper right arm by 4 patients during 16 study visits. Glucose was administered orally to induce 2 consecutive hyperglycemic excursions. For the analysis, global (valid for a population of patients), personal (tailored to a specific patient), and device-specific multiple linear regression models were derived. Results: We find that adjustments of the model to the patients improves the performance of the glucose estimation with an MARD of 17.8% for personalized model versus a MARD of 21.1% for the global model. At the same time the effect of the measurement side is negligible. The device can equally well measure on the left or right arm. We also see that devices are equal in the linear modeling. Thus hardware calibration of the sensors is seen to be sufficient to eliminate interdevice differences in the measured signals. Conclusions: We demonstrate that the hardware of the 2 devices worn on the left and right arms are consistent yielding similar measured signals and thus glucose estimation results with a global model. The 2 devices also return similar values of glucose errors. These errors are mainly due to nonstationarities in the measured signals that are not solved by the linear model, thus suggesting for more sophisticated modeling approaches.

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Section: Discussionmentioning

confidence: 99%

The Effect of a Global, Subject, and Device-Specific Model on a Noninvasive Glucose Monitoring Multisensor System

Caduff¹,

Zanon²,

Mueller³

et al. 2015

J Diabetes Sci Technol

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“…L'excrétion de sébum est le paramètre qui a été le plus fré-quemment retrouvé être soumis à un biorythme au niveau du visage [17,19,20,25,26]. Nous retrouvons un débit instantané de sébum qui est similaire au niveau du cuir chevelu.…”

Section: Discussionunclassified

“…L'existence d'un rythme circadien de la PIE sur le visage et sur les avant-bras reste débattue [18,20,25,26,34]. Dans notre étude sur le cuir chevelu, il apparaît que le biorythme circadien de la PIE avait une ampleur importante, quoique inférieure à celle de l'excrétion instantanée du sébum.…”

Section: Discussionunclassified

“…La température cutanée, l'intensité de la sudation, le flux de sébum et le pH de la couche cornée sont eux aussi soumis à des fluctuations au cours du nycthémère [17][18][19][20][21][22][23][24][25][26]. Dans tous les cas, ces rythmes ne sont pas directement influencés par la lumière.…”

Section: Introductionunclassified

“…L'érythème correspondant au volume sanguin superficiel subit aussi un rythme circadien. Il est cependant différent de celui du flux sanguin puisque ses valeurs maximales ont été rapportées à midi et à 20 h sur le visage [26].…”

Section: Introductionunclassified

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Chronophysiologie circadienne du cuir chevelu

Piérard‐Franchimont

Henry

Loussouarn

et al. 2007

Pathologie Biologie

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RésuméLes rythmes biologiques sont nombreux et ils sont également variés selon leurs périodicités et amplitudes. Des variations au cours du jour, et en particulier des rythmes circadiens ont été rapportés au niveau de la peau du visage et des avant-bras. Cependant, peu d'information existe au niveau des biorythmes quotidiens du cuir chevelu. Le but de l'étude était d'explorer la chronophysiologie du cuir chevelu. Nous rapportons des rythmes diurnes chez huit hommes caucasiens. Ils sont révélés par la méthode des plexogrammes par intervalles de quatre heures sur une période de cinq jours. Des biorythmes statistiquement significatifs furent retrouvés pour la couleur de la peau, son hydratation, sa fonction barrière, son pH et l'excrétion de sébum. Le début de l'après-midi était le moment d'accroissement maximum de la rougeur, de l'hydratation, du pH et du débit sébacé. Il correspondait aussi à la diminution maximale de la fonction barrière cutanée. L'amplitude de certains de ces biorythmes était si faible que leur pertinence clinique reste incertaine, même si le caractère statistique est significatif. Compte tenu de leur synchronisme apparent, il est probable qu'un oscillateur central exerce une influence prépondérante. Cependant, rares sont les individus qui expriment des biorythmes pour tous les paramètres physiologiques considérés. La réactivité périphérique joue donc également un rôle important pour définir les bons et les mauvais répondeurs au biorythme potentiel de chaque paramètre individuel. © 2007 Elsevier Masson SAS. Tous droits réservés. AbstractBiological rhythms are numerous and vary according to periodicity and amplitude. Variations over the course of a day, particularly circadian rhythms have been reported in the skin of the face and forearms. However, little information is available about daily biorhythms of the scalp. The aim of the present study was to explore the chronophysiology of the scalp. We report a series of diurnal rhythms in 8 Caucasian men using the plexogram method at 4-h intervals over a 5-day period. Statistically significant biorhythms were found for the colour, hydration, barrier function and pH of the skin, and for the sebum excretion as well. The early afternoon was the time of maximum increase in redness, hydration, pH and sebum output, combined with decreased skin barrier function. The amplitude of some of these biorhythms was so discrete that their clinical relevance remained uncertain even when they appeared statistically significant. In view of the apparent synchronization between them, it is likely that a central oscillator exerts a major influence. However, only rare subjects exhibited biorhythms for all the considered physiological parameters. Hence, peripheral reactivity and/or environmental synchronizers also play an important role to define the good and bad respondors to the potential biorhythms of each individual parameter.

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Clinical Medicine

Introducing Biological Rhythms

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Daily Variations in Skin Surface Properties Using Mixed Model Methodology

Cited by 18 publications

References 29 publications

The Effect of a Global, Subject, and Device-Specific Model on a Noninvasive Glucose Monitoring Multisensor System

The Effect of a Global, Subject, and Device-Specific Model on a Noninvasive Glucose Monitoring Multisensor System

Chronophysiologie circadienne du cuir chevelu

Clinical Medicine

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