Abstract. In this paper, to guarantee that the train can take measures to reduce the damage caused by the earthquake, it propose an irregular GI S curve fitting based high-speed railway earthquake influence range calculation model. Firstly, this model eliminates the abnormal points, calculates feature points and finds demarcation points of the highspeed railway GI S curve to get the processed point collection in Mercator coordinate. Secondly, though usin g the processed point collection, this model applies least square polynomial segmentation fitting method to implement complex high-speed GI S curve fitting. Thirdly, calculate the earthquake influence rang on high-seed railway line, according to the scope of the earthquake equation and the high -speed railway GI S curve fitt ed equation. Finally, the paper selects the Beijing So uth to Dezhou East high-speed railway section which is part of Beijing-Shanghai line a s a case study, which proves that the model can calculate the earthquake influence scope on the railway line offering decision support for train operation to ensure safety.