Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation

Pham, Ngoc Khanh; Bui, Huu Tai; Trần, Thu Hương; Hoang, Thi Ngoc Anh; Vu, Thi Ha; Tung, Dinh; Kim, Young Ho; Song, Seung‐Wan; Cuong, To Dao; Nguyen, Manh Cuong

doi:10.1016/j.steroids.2021.108902

Cited by 14 publications

(9 citation statements)

References 25 publications

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“…Further, Lin et al ( Lin et al, 2017 ) demonstrated that allicin-induced upregulation of ABCA1 promoted cholesterol efflux and reduced lipid accumulation through PPARγ/LXRα signalling in macrophage-derived foam cells. Three isolates (stigmast-4-en-3-one, cabraleahydroxylactone 3-acetate, and cabraleahydroxylactone 3-acetate) from the dichloromethane fraction of methanol extract of Dysoxylum tpongense plant possessed an anti-inflammatory effect against Liver X receptor (LXR) activation in HepG2 cell line ( Pham et al, 2021 ).…”

Section: Phytochemicals and Their Effect On Cholesterol Synthesismentioning

confidence: 99%

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

2022

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There are a plethora of cancer causes and the road to fully understanding the carcinogenesis process remains a dream that keeps changing. However, a list of role players that are implicated in the carcinogens process is getting lengthier. Cholesterol is known as bad sterol that is heavily linked with cardiovascular diseases; however, it is also comprehensively associated with carcinogenesis. There is an extensive list of strategies that have been used to lower cholesterol; nevertheless, the need to find better and effective strategies remains vastly important. The role played by cholesterol in the induction of the carcinogenesis process has attracted huge interest in recent years. Phytochemicals can be dubbed as magic tramp cards that humans could exploit for lowering cancer-causing cholesterol. Additionally, the mechanisms that are regulated by phytochemicals can be targeted for anticancer drug development. One of the key role players in cancer development and suppression, Tumour Protein 53 (TP53), is crucial in regulating the biogenesis of cholesterol and is targeted by several phytochemicals. This minireview covers the role of p53 in the mevalonate pathway and how bioactive phytochemicals target the mevalonate pathway and promote p53-dependent anticancer activities.

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Section: Phytochemicals and Their Effect On Cholesterol Synthesismentioning

confidence: 99%

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

2022

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“…Phytosterols have been reported for attenuating oxidative stress and inflammatory mediators and maintaining the hemostatic environment of the cell (Nattagh-Eshtivani et al, 2022;Pham et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The initiation of cancer is facilitated by elevated oxidative stress and inflammatory mediators, which trigger the alteration of the macromolecule, such as protein, lipids, and DNA molecules of the cell (Pham et al, 2021). This alteration in the macromolecule triggers the transformation of the normal cell into the tumorigenic cell.…”

Section: Introductionmentioning

confidence: 99%

“…Phytosterols have been reported for attenuating oxidative stress and inflammatory mediators and maintaining the hemostatic environment of the cell (Nattagh‐Eshtivani et al, 2022; Pham et al, 2021). The initiation of cancer is facilitated by elevated oxidative stress and inflammatory mediators, which trigger the alteration of the macromolecule, such as protein, lipids, and DNA molecules of the cell (Pham et al, 2021). This alteration in the macromolecule triggers the transformation of the normal cell into the tumorigenic cell.…”

Section: Introductionmentioning

confidence: 99%

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The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

Khan

Shal

et al. 2023

Phytotherapy Research

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Cancer is the leading cause of mortality and morbidity worldwide, and its cases are rapidly increasing every year. Several factors contribute to the development of tumorigenesis. including radiation, dietary lifestyle, smoking, environmental, and genetic factors. The cell cycle is regulated by a variety of molecular signaling proteins. However, when the proteins involved in the cell cycle regulation are altered, cellular growth and proliferation are significantly affected. Natural products provide an important source of new drug development for a variety of ailments. including cancer. Phytosterols (PSs) are an important class of natural compounds reported for numerous pharmacological activities, including cancer. Various PSs, such as ergosterol, stigmasterol, sitosterol, withaferin A, etc., have been reported for their anti‐cancer activities against a variety of cancer by modulating the tumor microenvironment via molecular signaling pathways discussed within the article. These signaling pathways are associated with the production of pro‐inflammatory mediators, growth factors, chemokines, and pro‐apoptotic and anti‐apoptotic genes. These mediators and their upstream signaling are very active within the variety of tumors and by modulating these signalings, thus PS exhibits promising anti‐cancer activities. However, further high‐quality studies are needed to firmly establish the clinical efficacy as well the safety of the phytosterols.

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“…Diverse compound groups of this genus, for instance, alkaloids [3][4], limonoids [5][6][7], steroids [8], sesquiterpenoids [9][10][11], diterpenoids [12][13][14], triterpenoids [15][16][17][18][19], and triterpenoid glycosides [20] mostly have been elucidated. Furthermore, numerous bioactive compounds such as central nervous system depressants, anti-respiratory syncytial virus, antifeeding, antitumor triterpenoid glycosides [20], antiinflammatory [3,17,[21][22], antirheumatic, and cardiacactive alkaloids [5], cytotoxic [23][24][25][26][27][28], antimicrobial [2,[18][19][20][21][22][23][24][25][26][27][28][29], and antibacterial [30][31] have been isolated from Dysoxylum plants.…”

Section: ■ Introductionmentioning

confidence: 99%

Triterpenoids from Stem Bark of <i>Dysoxylum excelsum</i> and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells

Meilanie

Mayanti²,

Nurlelasari³

et al. 2022

Indones. J. Chem.

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The diversity of structures of triterpenoids provides a variety of interesting pharmacological effects, one of them being anticancer. Sources of triterpenoids are found in Dysoxylum excelsum, it is still rarely studied, and it potentially contains triterpenoids with cytotoxic activity. Therefore, the research aimed to isolate the triterpenoids from the stem bark of D. excelsum and determine their cytotoxic efficacy against the breast cancer cells of MCF-7. The dried stem bark of D. excelsum was macerated using methanol and then fractionated with n-hexane and ethyl acetate to obtain the corresponding fractions. Two triterpenoids, 3α,7α-dihydroxyapotirucalla-14,24-Z-dien-26-oic acid (1) and masticadienonic acid or 3-oxo-tirucalla-7,24-Z-dien-26-oic acid (2) were isolated in the first place from the Dysoxylum genus. Compounds 1 and 2 were assayed for their cytotoxic potency anti- MCF-7 using the MTT assay and gave moderate IC50 values of 60.87 and 72.86 µM, respectively. Based on their analogs, partial structure modification of the compounds might increase the activity; thus, it can be further utilized as better lead compounds for anticancer drugs candidate.

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Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation

Cited by 14 publications

References 25 publications

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

Triterpenoids from Stem Bark of <i>Dysoxylum excelsum</i> and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells

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