Danazol and diabetes

Golland, I. M.; Ca, Williams; Shalet, SM

doi:10.1002/pdi.1960060120

Cited by 1 publication

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although hyperglu¬ cagonaemia was well established within six weeks of starting treatment with danazol, we are unable to say how rapidly this change developed, nor whether such a change was sustained for the du¬ ration of the treatment period. It has been previously reported (1)(2)(3)(4)(5) that treat¬ ment with danazol does not change the concentra¬ tions of glucose or insulin in the fasting state, al¬ though, in response to an oral glucose load, glucose tolerance is impaired, hyperinsulinaemia develops, and the insulin/glucose ratio is increased, thereby demonstrating an increase in insulin resistance. In this study, the insulin response to an oral glucose load was increased, confirming the development of insulin resistance but without change in the fasting or summed concentration of glucose.…”

Section: Discussionmentioning

confidence: 99%

“…This may influence the choice of drug for the treatment of endometriosis in those women known to have impaired glucose tolerance (5).…”

Section: Discussionmentioning

confidence: 99%

“…During such treatment, hyperinsulinaemia and in¬ sulin resistance develop independently of any as¬ sociated weight gain, although, typically, the fast¬ ing insulin concentration is not increased (1)(2)(3)(4)(5).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Influence of danazol and goserelin on insulin and glucagon in non-obese women with endometriosis

Golland¹,

Vaughan-Williams²,

Shalet³

et al. 1990

Acta Endocrinologica

View full text Add to dashboard Cite

To investigate the effects of medical treatment of endometriosis on concentrations of insulin and glucagon in comparison with those of androgens, 12 nonobese women with minimal endometriosis were randomly allocated to receive treatment with either danazol or the gonadotropin-releasing hormone analogue, goserelin. In subjects treated with danazol, mean (sd) summed serum insulin (1.08 (0.22) nmol/l pretreatment; 3.00 (1.50) nmol/l after treatment, p<0.05) and summed plasma glucagon (94 (21) pmol/l pretreatment; 238 (113) pmol/l after treatment, p<0.05) responses to oral glucose administration increased significantly, but remained unchanged in subjects treated with goserelin. In the danazol-treated group, the mean free testosterone index increased from 3.3 (1.6) to 13.3 (4.2) (p<0.01), but there was no correlation between either glucagon or insulin and free testosterone index. In the goserelin-treated subjects, however, there was no change in mean free testosterone indices (pretreatment 3.6 (1.0), post-treatment 3.9 (1.8). Thus, the increase in free testosterone index induced by danazol treatment is not responsible for the concomitant development of hyperinsulinaemia and hyperglucagonaemia.

show abstract

Section: Discussionmentioning

confidence: 99%

“…This may influence the choice of drug for the treatment of endometriosis in those women known to have impaired glucose tolerance (5).…”

Section: Discussionmentioning

confidence: 99%