Dandelion flower-like micelles

Yao, Yongchao; Xu, Duanyang; Zhu, Yuhong; Dai, Xin; Yu, Yunlong; Luo, Jianbin; Zhang, Shiyong

doi:10.1039/c9sc05741b

Cited by 18 publications

(7 citation statements)

References 70 publications

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“…29,30 By taking the advantages of these hydrophilic and hydrophobic segments, three blocks of hydrophilic-hydrophobichydrophilic copolymer as micellar materials could be designed, such as Poloxamer (PEO-PPO-PEO), etc. 28 In addition to the variety of materials, polymeric micelles can form a wide variety of shapes, including spherical, 15 rod-shaped, 31 worm-like, 32 dandelion flower-like, 33 and starshaped, 34 etc, while the shape of a micelle is related to the length or type of its hydrophilic and hydrophobic segments.…”

Section: Characteristics Of Polymeric Micellesmentioning

confidence: 99%

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Liu

et al. 2021

Nanoscale Adv.

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Section: Characteristics Of Polymeric Micellesmentioning

confidence: 99%

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Liu

et al. 2021

Nanoscale Adv.

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“…For precise treatment, an instantaneous response to external stimuli is urgently needed for the fast release of drugs at the lesion site. [6][7][8]32,33 It remains challenging to overcome the abovementioned problems using polymersomes.…”

Section: ■ Introductionmentioning

confidence: 99%

“…However, thick hydrophobic layers present in polymersomes can compromise permeability with permeability rate reduction proportional to the reciprocal of the membrane thickness. ,, Additionally, the presence of larger hydrophobic (macromolecular) segments slows down the response time. For precise treatment, an instantaneous response to external stimuli is urgently needed for the fast release of drugs at the lesion site. − ,, It remains challenging to overcome the abovementioned problems using polymersomes.…”

Section: Introductionmentioning

confidence: 99%

Azobenzene-Based Cross-Linked Small-Molecule Vesicles for Precise Oxidative Damage Treatments Featuring Controlled and Prompt Molecular Release

Yao

Wan

et al. 2021

Chem. Mater.

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Precise therapy has become prevalent in clinical practice owing to its accurate and efficient targeting treatment of diseases. Such treatments involving polymersomes as carriers have great potential to lesion sites without damage to normal tissues. However, due to the inherent thick hydrophobic layer of polymersomes, an instantaneous release response to external stimuli remains a challenge. To tackle this challenge, here, we report on the synthesis and applications of azobenzene-containing photochromic vesicles as delivery vectors. These vesicles are assembled from small-molecule amphiphiles that have been developed to provide a fast response and promote instantaneous release due to molecular size reduction compared with macromolecular polymersomes. After cross-linking, the stability of vesicles under a physiological environment is notably enhanced. By varying UV and visible light irradiation, the "gate" of vesicles can be opened and closed reversibly for the controlled release of capsuled cargoes. In vitro experiments display that the vesicles can be applied to load cysteamine for eliminating excess reactive oxygen. The synthesized vesicles here show high performance in controlled and instantaneous release in cells both in time and space. By our approach, oxidative damage to cellular biomolecules can be substantially reduced.

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“…Stimuli-responsive soft nanomaterials, such as micelles, vesicles, and gel particles, are of great interest because they have a variety of applications, in drug delivery systems, − smart catalytic systems, − separators, − reaction scaffolds, etc. In particular, multiple stimuli-responsive soft nanomaterials that change their properties in response to two or more stimuli have tremendous advantages compared to single stimuli-responsive systems because of their precisely responsive behavior. − Multiple stimuli-responsive soft nanomaterials exhibit structural responses involving shape transformations, assembly, and disassembly.…”

Section: Introductionmentioning

confidence: 99%

Weakly Acidic pH and Reduction Dual Stimuli-Responsive Gel Particles

et al. 2021

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This paper reports the facile preparation of dual stimuli-responsive gel particles that simultaneously respond to weakly acidic and reducing stimuli and the application of these gel particles as a drug delivery carrier. The dual stimuli-responsive gel particles composed of a pH-responsive polymer network crosslinked with reduction stimuli-responsive disulfide cross-links, and biocompatible poly(ethylene glycol) cross-links were prepared by soap-free emulsion polymerization. The resulting gel particles were colloidally stable at physiological ionic strength and had a diameter of approximately 200 nm with a narrow size distribution. The resulting gel particles slightly swelled in an acidic environment. On the other hand, the gel particles drastically swelled under simultaneous weakly acidic and reducing conditions because of the ionization of tertiary amino groups in the gel network and a decrease in the cross-linking density resulting from cleavage of the disulfide cross-links. When cells were treated with the gel particles, they were taken up by cells via the endocytosis pathway and distributed in the cytosol after endosomal escape by the proton sponge effect. In addition, a hydrophobic drug, doxorubicin (Dox), was loaded into the gel particles through hydrophobic interactions. Dox was released from the gel particles under weakly acidic and reducing conditions, while the Dox release was inhibited at neutral pH. The weakly acidic pH-and reduction stimuli-responsive release of Dox from gel particles was attributed to the drastic swelling of these particles. The fascinating properties of the dual stimuli-responsive gel particles suggest that they can provide a useful platform for designing intracellular drug delivery carriers.

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Dandelion flower-like micelles

Abstract: Dandelion flower-like micelles (DFMs) can release surface cross-linked micelles (SCMs) by non-Brownian motion at an average speed of 19.09 μm s−1 upon reductive stimuli.

Cited by 18 publications

References 70 publications

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Azobenzene-Based Cross-Linked Small-Molecule Vesicles for Precise Oxidative Damage Treatments Featuring Controlled and Prompt Molecular Release

Weakly Acidic pH and Reduction Dual Stimuli-Responsive Gel Particles

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