Dandy-Walker Malformation Presenting with Affective Symptoms

Batmaz, Mert; Balçık, Zeynep Ezgi; Özer, Ürün; Yalçin, Burcu Hamurişçi; Özen, Şakir

doi:10.5152/npa.2017.18114

Cited by 4 publications

(8 citation statements)

References 29 publications

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“…Previous case reports have mentioned that there may be a relationship between MCM and psychiatric symptoms. This relationship is more evident in malformations affecting the vermis and cerebellar hemispheres [14,15]. However, in proton magnetic resonance spectroscopy, it was observed that the levels of gamma-aminobutyric acid (GABA) were decreased in the cerebellar tissue of patients diagnosed with unipolar and bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Mega cisterna magna in bipolar mood disorder: a case report

et al. 2022

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Mega cisterna magna (MCM), one of the members of the Dandy-Walker complex, is a developmental malformation of the posterior fossa that is larger than 10 mm but morphologically does not affect the vermis and cerebellar hemispheres. Reports of psychiatric disorders associated with this anomaly are rare. We present the case of a patient with MCM who presented with a psychotic manic attack and was diagnosed with bipolar disorder. A 28-year-old female, single housewife, university graduate, presented with irritability, decreased sleep and appetite, distraction, and agitation. The patient also had a delusion of reference. In the clinical follow-up, an increase in energy and an increase in the amount of speech were observed. Her neurological examination was normal, and cranial magnetic resonance imaging revealed an MCM. The relationship and clinical significance of MCM with psychosis and mood disorders have not yet been fully elucidated. It is not known whether this association is accidental or based on etiological commonality. The purpose of this case report is to review the relationship between the cerebellum and psychiatric symptoms and to contribute to the literature.

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Section: Discussionmentioning

confidence: 99%

Mega cisterna magna in bipolar mood disorder: a case report

et al. 2022

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“…Most patients were initially admitted to an inpatient setting (n = 27; 75%), due to acute psychiatric manifestations [20][21][22][23][24][25][26][27][28]30,34,36,[39][40][41][42][43][44][45][46][48][49][50][51][52][53], in some cases requiring compulsory admission [23,24,34,39,51]. Conversely [31][32][33], only eight patients were exclusively assessed on an outpatient basis [29,32,33,35,37,38,41,43].…”

Section: Use Of Psychopharmacological Medications and Clinical Coursementioning

confidence: 99%

“…At first presentation, 10 patients (27,8%) were not taking any medications [23,25,27,35,36,39,[43][44][45], 15 patients (41.7%) were on monotherapy [20,21,26,31,32,34,[40][41][42][47][48][49][50][51][52], and 11 patients (30.5%) were on polytherapy [22,24,[28][29][30]33,34,37,38,46,53]. The most prescribed drugs at presentation were second- [21,22,24,26,29,32,34,37,38,41,42,[47][48][49][50]…”

Section: Use Of Psychopharmacological Medications and Clinical Coursementioning

confidence: 99%

“…The most prescribed drugs at presentation were second- [21,22,24,26,29,32,34,37,38,41,42,[47][48][49][50]53] and firstgeneration [28,33,37,52,53] antipsychotics, followed by mood stabilizing agents [22,[28][29][30][31]46], antidepressants [20,33,34,38,51], and anxiolytics and hypnotic/sedatives [34,40,46]. At discharge, only four patients (11.1%) were not being prescribed any medications (with a 60% decrease compared to presentation) [28,36,40,51], nine patients (25%) were on monotherapy (with a 40% decrease compared to presentation) [21,34,35,43,[45][46][47][48]…”

Section: Use Of Psychopharmacological Medications and Clinical Coursementioning

confidence: 99%

“…Among patients who were not taking any medications, one underwent electroconvulsive therapy [40]. Consistent with presentation, the most prescribed drugs among treated patients were second- [21,[23][24][25][26][27][29][30][31][32]34,35,37,38,[41][42][43]45,[47][48][49][50]52,53] and first-generation antipsychotics [33,37,49], followed by mood stabilizing agents (with a 100% increase compared to presentation) [20,22,24,29,31,34,39,42,43,46,50,53], antidepressants (with an 80% increase compared to presentation) [20,25,26,33,34,38,39,41,…”

Section: Use Of Psychopharmacological Medications and Clinical Coursementioning

confidence: 99%

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Tic-Related Obsessive–Compulsive and Eating Disorders in Dandy–Walker Variant: A Case Report and Systematic Reappraisal of Psychiatric Profiles

Bortoletto,

Candolo,

Nicotra

et al. 2024

Brain Sciences

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Dandy–Walker complex (DWC) consists of a continuum of brain malformations involving the posterior fossa, often leading to psychiatric manifestations during adulthood. We discussed the case of a young woman with Dandy–Walker variant (DWV) and a comorbid complex neuropsychiatric presentation, who was diagnosed with an eating disorder, obsessive–compulsive disorder, and a tic disorder. Afterwards, we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review reappraising all evidence of psychiatric outcomes in adults with DWC. Overall, 34 studies were eligible for data extraction, comprising 36 patients. Psychiatric profiles were more common among young adult males, with DWC lesions, especially DWV subtype, being often discovered incidentally after admission to mental health inpatient facilities. Most patients were diagnosed with psychosis and bipolar disorder, often comorbid with cognitive impairment. Psychotropic polypharmacy was frequently prescribed, generally leading to complete recovery. Evidence from our case report and systematic review indicates the importance of monitoring long-term psychiatric sequelae among adult patients with DWC malformations.

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