Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide

Koike, Kazuhide; Yoo, Sung Jin; Bleymehl, Katherin; Omura, Masayo; Zapiec, Bolek; Pyrski, Martina; Blüm, Thomas; Khan, Mona; Bai, Zhaodai; Leinders‐Zufall, Trese; Mombaerts, Peter; Zufall, Frank

doi:10.1016/j.neuron.2021.05.032

Cited by 19 publications

(15 citation statements)

References 89 publications

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“…Nevertheless, Trpa1 mRNA was expressed with only a low number of copies in the OE, and it was not colocalised with anti-β-tubulin III, a selective marker of OSNs [44,45], suggesting that the receptor may be expressed in other OE structures (e.g., on the ending of trigeminal neurons or in type B cells) [52]. The synthesis of this TRPA1 receptor protein may happen predominantly in the perikaryon of TG neurons, where Trpa1 expression has been confirmed previously [53][54][55], contributing to the development of diverse (patho)physiological conditions [48].…”

Section: Discussionmentioning

confidence: 97%

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice

et al. 2021

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Transient receptor potential ankyrin 1 (TRPA1), a nonselective cation channel, contributes to several (patho)physiological processes. Smell loss is an early sign in several neurodegenerative disorders, such as multiple sclerosis, Parkinson’s and Alzheimer’s diseases; therefore, we focused on its role in olfaction and social behaviour with the aim to reveal its potential therapeutic use. The presence of Trpa1 mRNA was studied along the olfactory tract of mice by combined RNAscope in situ hybridisation and immunohistochemistry. The aversive effects of fox and cat odour were examined in parallel with stress hormone levels. In vitro calcium imaging was applied to test if these substances can directly activate TRPA1 receptors. The role of TRPA1 in social behaviour was investigated by comparing Trpa1 wild-type and knockout mice (KO). Trpa1 mRNA was detected in the olfactory bulb and piriform cortex, while its expression was weak in the olfactory epithelium. Fox, but not cat odour directly activated TRPA1 channels in TRPA1-overexpressing Chinese Hamster Ovary cell lines. Accordingly, KO animals showed less aversion against fox, but not cat odour. The social interest of KO mice was reduced during social habituation–dishabituation and social interaction, but not during resident–intruder tests. TRPA1 may contribute to odour processing at several points of the olfactory tract and may play an important role in shaping the social behaviour of mice. Thus, TRPA1 may influence the development of certain social disorders, serving as a potential drug target in the future.

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Section: Discussionmentioning

confidence: 97%

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice

et al. 2021

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“…Interestingly, the long-lasting responses with the skunk secretions are the same in the two models. This kind of response can also be observed in primarily in other studies testing sulfuric molecules and their impact (for example, in main olfactory epithelium (MOE) subsystem) [35] Knowing that skunk spray is a strong defensive protection for them in the wild, this is unsurprising. The defensive spray produced by their glands contains specifical thiols volatile molecules that can last over time [36].…”

Section: Discussionmentioning

confidence: 69%

From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion

Lópes

Brechbühl

Ferreira

et al. 2022

Animals

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In the wild, mice have developed survival strategies to detect volatile cues that warn them of potential danger. Specific olfactory neurons found in the Grueneberg ganglion olfactory subsystem can detect alarm pheromones emitted by stressed conspecifics, as well as kairomones involuntarily released by their predators. These volatile chemical cues allow intra- and interspecies communication of danger, respectively. Alarm pheromones, kairomones and bitter taste ligands share a common chemical motif containing sulfur or nitrogen. Interestingly, three specific bitter taste receptors (TAS2Rs) have been found in the Grueneberg ganglion neurons that are implicated in danger signalling pathways. We have recently developed a TAS2R–expressing heterologous system that mimics the Grueneberg ganglion neuron responses after kairomone stimulation. Here, we demonstrated by in vitro, ex vivo and in vivo experiments that the biological secretions from the raccoon (Procyon lotor) and the skunk (Mephitis mephitis) were acting as potent sources of kairomones. They activated the Grueneberg ganglion neurons and induced fear-related behaviours in mice. Identification of new sources of semiochemicals is a first step towards an understanding of the interspecies danger communication that takes place in the Grueneberg ganglion.

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“…Studies have shown that Trpc2 is also expressed in the MOE ( Bleymehl et al., 2016 ; Omura and Mombaerts, 2015 ), which indicates that Trpc2 in the MOE may also contribute to defects in infanticidal behavior. However, a recent study showed that Trpc2-mediated signaling in the MOE is independent of Cnga2 and does not depend on intact cilia ( Koike et al., 2021 ), which indicates that Trpc2-mediated signaling in the MOE is unlikely to contribute to the infanticidal behavior of adult virgin male mice.…”

Section: Discussionmentioning

confidence: 99%

The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice

Yang

Zhou

et al. 2022

iScience

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Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide

Cited by 19 publications

References 89 publications

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice

From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion

The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice

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