Dangnyohwan improves glucose utilization and reduces insulin resistance by increasing the adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima Fatty rats

Park, Seung Yeon; Choi, Young-Hee; Lee, Wan

doi:10.1016/j.jep.2007.10.040

Cited by 14 publications

(6 citation statements)

References 53 publications

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“…So, from all these studies, the clearest conclusion that can be drawn is a rough estimation of the effective dose in humans: around 100-500 mg polyphenols daily, acutely administered for two to three weeks. It is important to bear in mind that this dosage is ten times higher than the estimated normal intake 2008).…”

Section: Human Studiesmentioning

confidence: 93%

“…Only some studies postulate a relationship between the effects and the clearly identified ability of procyanidins to improve inflammatory response 2008). So, from all these studies, the clearest conclusion that can be drawn is a rough estimation of the effective dose in humans: around 100-500 mg polyphenols daily, acutely administered for two to three weeks.…”

Section: Human Studiesmentioning

confidence: 99%

“…So, flavonoids include thousands of structures with different chemical, physical, and biological properties which perform a wide array of biochemical and pharmacological actions such as cardioprotective , antioxidant (Williams et al, 2004), anti-inflammatory (Rivera et al,569 Downloaded by [University of Toronto Libraries] 2008), antiallergic, antiviral, and anticarcenogenic (Amin and Buratovich, 2007;Kim et al, 2008) activities. Among their effects, several monomeric flavonoids and natural extracts rich in monomeric forms have been shown to improve hyperglycemia in streptozotocin-induced diabetic rats, in genetically altered diabetic mice, and in animal models with diet-induced insulin resistance or diabetes (Potenza et al, 2007;Park, 2008;Bose et al, 2008;Cao et al, 2007;Diepvens et al, 2006). This review focuses on the effects of the largest and most ubiquitous class of flavonoids, the flavan-3-ols, which comprise the main constitutive units of condensed procyanidins.…”

Section: Introductionmentioning

confidence: 99%

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Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An Analysis of Doses and Treatments According to Different Animal Models

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Cedó

Montagut

et al. 2012

Critical Reviews in Food Science and Nutrition

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This review analyses the potential beneficial effects of procyanidins, the main class of flavonoids, in situations in which glucose homeostasis is disrupted. Because the disruption of glucose homeostasis can occur as a result of various causes, we critically review the effects of procyanidins based on the specific origin of each type of disruption. Where little or no insulin is present (Type I diabetic animals), summarized studies of procyanidin treatment suggest that procyanidins have a short-lived insulin-mimetic effect on the internal targets of the organism, an effect not reproduced in normoglycemic, normoinsulinemic healthy animals. Insulin resistance (usually linked to hyperinsulinemia) poses a very different situation. Preventive studies using fructose-fed models indicate that procyanidins may be useful in preventing the induction of damage and thus in limiting hyperglycemia. But the results of other studies using models such as high-fat diet treated rats or genetically obese animals are controversial. Although the effects on glucose parameters are hazy, it is known that procyanidins target key tissues involved in its homeostasis. Interestingly, all available data suggest that procyanidins are more effective when administered in one acute load than when mixed with food.

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Section: Human Studiesmentioning

confidence: 93%

Section: Human Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An Analysis of Doses and Treatments According to Different Animal Models

Pinent

Cedó

Montagut

et al. 2012

Critical Reviews in Food Science and Nutrition

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“…In paediatric use, A. asphodeloides is employed for the treatment of paediatric epilepsy, fever, coughing and allergies due to its properties of removing pathogenic heat (Park et al. 2008 ; Wang et al. 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes

Wang

Jiang

Zhou

et al. 2020

Pharmaceutical Biology

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Context Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine. Objective This study investigates the effects of anemarsaponin BII on the activity of CYP450s to provide more guidance for the clinical use of anemarsaponin BII. Materials and methods Using various diagnostic substrates, the effects of a fixed concentration of anemarsaponin BII (100 μM) on the activity of eight main isoforms of CYP450s (CYP1A2, 2A6, 3A4, 2C8, 2C9, 2C19, 2D6 and 2E1) was first studied with pooled human liver microsomes (HLMs). Then, dose-dependent (0, 2.5, 5, 10, 25, 50 and 100 μM anemarsaponin BII) and time-dependent (0, 5, 10, 15 and 30 min) experiments were performed to obtain corresponding kinetic parameters. Results Anemarsaponin BII showed significant inhibitory effects on the activity of CYP3A4, 2D6 and 2E1 with the IC 50 values of 13.67, 16.26 and 19.72 μM. Anemarsaponin BII acted as a non-competitive inhibitor of CYP3A4 with the K I value of 6.72 μM and competitive inhibitors of CYP2D6 and 2E1 with the K I values of 8.26 and 9.82 μM, respectively. Additionally, the inhibition of CYP3A4 was revealed to be time-dependent with the K I value of 4.88 μM and the K inact value of 0.053/min. Conclusions The inhibitory effect of anemarsaponin BII on the activity of CYP3A4, 2D6 and 2E1 indicated the potential drug–drug interaction between anemarsaponin BII and drugs metabolized by these CYP450s. Further in vivo experiments are needed to validate the potential drug–drug interactions.

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“…Of them, the rhizome of Anemarrhena asphodeloides Bunge (Asparagaceae) is widely administered as traditional medicine in China, Korea and Japan for the treatment of inflammatory disorders, including fever, coughs, allergies, diabetes, and Alzheimer's disease (7,8). Numerous previous studies support the use of A. asphodeloides for the treatment of various inflammatory disorders.…”

Section: Introductionmentioning

confidence: 99%

Suppression of inflammation by the rhizome of Anemarrhena asphodeloides via regulation of nuclear factor-κB and p38 signal transduction pathways in macrophages

Kim

Cho

et al. 2017

Biomedical Reports

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Abstract. The rhizome of Anemarrhena asphodeloides Bunge (A. asphodeloides) has been used as a traditional East Asian medicine for the treatment of various types of inflammatory disease. However, to the best of our knowledge, there have been no systemic studies regarding the molecular mechanisms of action of the A. asphodeloides rhizome anti-inflammatory effects. The aim of the present study was to elucidate the anti-inflammatory effects and underlying mechanism of action of ethanol extracts of the rhizome of A. asphodeloides (EAA) in murine macrophages. Non-cytotoxic concentrations of EAA (10-100 µg/ml) significantly decreased the production of NO and interleukin (IL)-6 in lipopolysaccharide (LPS)-stimulated macrophages, while the production of tumor necrosis factor-α was not regulated by EAA. EAA-mediated reduction of nitric oxide (NO) was due to reduced expression levels of inducible NO synthase (iNOS). Furthermore, protein expression levels of LPS-induced cyclooxygenase-2, another inflammatory enzyme, were alleviated in the presence of EAA. EAA-mediated reduction of those proinflammatory mediators was due to inhibition of nuclear factor-κB (NF-κB) and activator protein 1 transcriptional activities followed by the stabilization of inhibitor of κ Bα and inhibition of p38, respectively. These results indicate that EAA suppresses LPS-induced inflammatory responses by negatively regulating p38 and NF-κB, indicating that EAA is a candidate treatment for alleviating inflammation.

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Dangnyohwan improves glucose utilization and reduces insulin resistance by increasing the adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima Fatty rats

Cited by 14 publications

References 53 publications

Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An Analysis of Doses and Treatments According to Different Animal Models

Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An Analysis of Doses and Treatments According to Different Animal Models

Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes

Suppression of inflammation by the rhizome of Anemarrhena asphodeloides via regulation of nuclear factor-κB and p38 signal transduction pathways in macrophages

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