2007
DOI: 10.1016/j.ijrobp.2006.09.037
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Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133− cells, and the CD133+ sector is enlarged by hypoxia

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Cited by 233 publications
(196 citation statements)
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“…However, recent data cast doubt on these early findings. Under hypoxic conditions, CD133 À CSCs expressed CD133 þ (38,39). Also, in vivo studies showed that CD133 À CSCs drive tumorigenesis in nude rats (24,40).…”
Section: Discussionmentioning
confidence: 98%
“…However, recent data cast doubt on these early findings. Under hypoxic conditions, CD133 À CSCs expressed CD133 þ (38,39). Also, in vivo studies showed that CD133 À CSCs drive tumorigenesis in nude rats (24,40).…”
Section: Discussionmentioning
confidence: 98%
“…In this heterogeneous tumor, CD133À cells in long-term culture were found to be capable of tumor initiation in mice (Chen et al, 2010), although many recent publications maintain that not only is the CD133 þ fraction enriched in BTIC capacity Yan et al, 2011), but the features of 'stemness' marked by CD133 are associated with increasing malignancy and poor patient outcome (Bao et al, 2006;Thon et al, 2008;McCord et al, 2009;Pallini et al, 2010). In medulloblastoma, evidence more uniformly supports the application of CD133 as a BTIC marker, as CD133 þ multipotent NSCs were described in the postnatal cerebellum (Lee et al, 2005), and further studies showed that CD133 enriched for brain tumor-initiating capacity and radioresistance in primary and Daoy medulloblastoma-derived tumors (Fan et al, 2006;Blazek et al, 2007;Annabi et al, 2008Annabi et al, , 2010Pistollato et al, 2010;Yu et al, 2010). In contrast to previous experiments performed on unsorted cells, we found a differential expression of Hh pathway components between the CD133 þ stem-like cells and the CD133À late progenitors or differentiated cells.…”
Section: Shh Regulates Bmi1 In Medulloblastoma Bticsmentioning
confidence: 99%
“…CSC population is increased in hypoxic conditions, which means that HIF-1 may be stabilized in these cells. This can have a role in tumor radioresistance (Blazek et al, 2007).…”
Section: Cscs and Angiogenesismentioning
confidence: 99%