Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway

Schisandrin B inhibits epithelial‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways

“…Additionally, the association between p38 MAPK and NF-κB activation has been confirmed in lung cancer cells (46). The p38 MAPK signaling pathway has been verified to regulate the NF-κB signaling pathway (47). Additionally, p38 functions as a facilitator in the transcriptional activity of NF-κB via mitogen-and stress-activated kinase 1-mediated p65 phosphorylation (48).…”

Management of Acute Lung Injury: Palmitoylethanolamide as a New Approach

“…As a result, treatment with um-PEA efficaciously blocked the phosphorylations of IκBα, NF-κB, which suggested that um-PEA suppressed excessive cytokine production by inhibiting NF-κB activation. With regard to the intracellular signaling involved in LPS-induced ALI, it is well known that increases in the production of inflammatory factors are associated with the phosphorylation of MAP kinases, such as p-38, ERK1/2 and JNK [ 52 , 53 , 54 ]. Moreover, previous study showed that PEA was able to reduce the p-ERK, as well as JNK/p38 levels after damage, in several models, like postoperative pain in vivo model or astrogliosis in vitro [ 55 , 56 , 57 ].…”

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock

“…TLR4 has been reported to be enhanced in THSinduced acute lung injury [ 29 , 30 ]. Studies have also revealed the activation of p38MAPK/NF-κB pathway in THS-induced acute lung injury and lung injury [ 29 , 31 , 32 ]. Furthermore, we measured the related protein expression in the TLR4/p38MAPK/NF-κB pathway in THS-induced lung injury models.…”