Dark adaptation in early primary biliary cirrhosis

Abstract

Patients with early PBC have modestly impaired dark adaptation, despite standard vitamin A supplementation, although these changes may not have a significant effect on visual function. Vitamin A supplementation should be recommended for older patients with jaundice, but its effect should be carefully monitored.

Dark adaptation pattern of pregnant women as an indicator of functional disturbance at acceptable serum vitamin A levels

“…However, it is difficult to compare the final light threshold of any group of this study with absolute figures of other dark adaptation study results with any degree of validity and sense. The problem arises from the fact that investigators used various techniques and methods (Goldman-weekers, Friedmann visual field analyzer, pupillary threshold method, etc) to assess scoropic vision pattern (Hussaini et al, 1998;Herlong et al, 1981;Congdon et al, 2000). Methods vary in defining dark adaptation, their calibration and spectral composition, initial dark adaptation level, age, sex grouping etc.…”

Assessment of Retinotopic Rod Photoreceptor Function Using a Dark-Adapted Chromatic Perimeter in Intermediate Age-Related Macular Degeneration

“…8 Subjects were excluded from the study if they had choroidal neovascularization, geographic atrophy, OCT, or FAF signs of atrophy or nascent GA, 9 and any other ocular disease that could compromise visual function, including glaucoma, significant cataracts ( ‡2 score on the Age-Related Eye Disease Study [AREDS] cataract grading system 10 ), diabetic retinopathy, amblyopia, history of previous eye surgery, and medications known to affect retinal function, such as hydroxychloroquine. In addition, subjects with medical conditions that could affect dark adaptation (such as liver disease 11 and renal disease 12 ) also were excluded.…”

Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment

“…Underperception of night blindness has been reported by others in ALD,13 PBC14 24 and also in malnutrition. Our study confirmed underperception of impairment of DA which is a risk to patient safety.…”