Das Elektronen-, Positronen- und Gammaspektrum des64Cu

Abstract

Mit einem Szintillationsspektrometer wurden das fi--und /~+-Spektrum des 6JCu(T1/~ = 12,g h) untersucht. Das' Prgparat befand sich in einem Anthracen-Spaltkristall, der in einen NaJ-Lochkristall eintauchte. In Koinzidenz mit der Vernichtungsstrahlung, die im NaJ-Kristall nachgewiesen wurde, wurden die Positronen, in Antikoinzidenz die Elektronen gemessen.

Optimization of Pentadentate Bispidines as Bifunctional Chelators for64Cu Positron Emission Tomography (PET)

“…The crude product was recrystallized from acetone to afford a yellow crystalline solid in a yield of 55.3% (3.23 g, 20.63 mmol). 1 H NMR (400 MHz, DMSO-d 6 ): δ = 7.50 (dd, 3 J H,H = 5.14 Hz, 4 15 mmol, 1.0 equiv) was dissolved in trifluoroacetic acid (30 mL) and cooled to 0 °C. At this temperature zinc dust was added portionswise to the reaction solution; a strong delayed reaction was observed.…”

“…The product was obtained as a red-brown oil in a yield of 62.4% (0.62 g, 4.35 mmol). 1 H NMR (400 MHz, CDCl 3 ): δ = 1.75 (s, 2H, CH 2 NH 2 ), 3.98 (s, 2H, CH 2 NH 2 ), 7.18 (dd, 3 J H,H = 5.14 Hz, 4 J H,H = 1.10 Hz, 1H, H 5 ), 7.34−7.36 (m, 1H, H 3 ), 8.46 (d, 3 J H,H = 5.40 Hz, 1H, H 6 ). 13 Bispidine B4 (C 30 H 33 N 5 O 7 , M W = 575.61 g/mol).…”

Bispidine Dioxotetraaza Macrocycles: A New Class of Bispidines for64Cu PET Imaging

“…With positron emitters, for example 64 Cu ions, an important focus is on the design of bifunctional chelators (BFCs) that coordinate the β + emitting metal ion with high stability and offer functional groups for conjugation to biological vector molecules. Because of its suitable half-lifetime of 12.7 h and its decay scheme (β + , 19%; β – , 40%; and electron capture 40%), 64 Cu is an ideal positron emitter for PET imaging, and the “matched-pair” 64 Cu/ 67 Cu offers possible applications in diagnosis and therapy. − There is a range of well-known ligand systems for stable and well-defined Cu II complexes, and derivatives of these ligands have been used as BFCs for PET imaging. Examples are ATSM (diacetyl-bis( N 4-methylthiosemicarbazone), , derivatives of aza-macrocycle ligand systems, including TETA and DOTA, − derived from the 14- and 12-membered cyclam- and cyclen-type aza-macrocycles, and hexamine cage ligands. − An advantage of these systems is the high thermodynamic stability (macrocyclic effect , ) and facile methods for the attachment of functionalities such as carboxylates, where a biofunctionalization can be performed.…”

“…The aqueous buffered solutions (HEPES/NaOH buffer) consist of 100 μM bispidine ligands, 10 μM Cu(NO 3 ) 2 , and 300 kBq [64 Cu]CuCl 2 . The distribution experiments in 1-octanol/buffer systems were performed at 25 ± 1 °C in microcentrifuge tubes (2 cm3…”

Investigation of dual decay of70Ga (21 min)

“…The effect of /~--absorption in the sample was less than 1% [5]. The electron spectrometer was inserted into a well typ NaJ-crystal [6]. The efficiency of the NaJ-crystal, 10.2 cm diam., 10.2 cm in height, was measured with calibration standards [7] and by the summing technique [8].…”