2024
DOI: 10.1002/advs.202309972
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Data‐Driven Engineering of Phages with Tunable Capsule Tropism for Klebsiella pneumoniae

Chao Wang,
Shiwei Wang,
Shisong Jing
et al.

Abstract: Klebsiella pneumoniae, a major clinical pathogen known for causing severe infections, is attracting heightened attention due to its escalating antibiotic resistance. Phages are emerging as a promising alternative to antibiotics; however, their specificity to particular hosts often restricts their use. In this study, a collection of 114 phages is obtained and subjected to analysis against 238 clinical K. pneumoniae strains, revealing a spectrum of lytic behaviors. A correlation between putative tail protein clu… Show more

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