Data-enriched edible pharmaceuticals (DEEPs): Patients' preferences, perceptions, and acceptability of new dosage forms and their digital aspects – An interview study

Chao, Meie; Genina, Natalja; Beer, Netta; Sporrong, Sofia Kälvemark

doi:10.1016/j.rcsop.2022.100141

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…However, according to the patients' feedback, the size of the dosage form should not be larger than the size of the tongue. [ 40 ] The chosen area of 4.91 cm 2 is just below the dimensions of the tongue. Whether further increase in the printed area is desired, it would be recommended to roll the printed module into the standard capsule shell to improve the acceptability of the dosage form by patients.…”

Section: Resultsmentioning

confidence: 99%

Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication

Ahola,

Raijada,

Cornett

et al. 2024

Advanced Materials

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An abrupt cessation of antidepressant medication can be challenging due to the appearance of withdrawal symptoms. A slow hyperbolic tapering of an antidepressant, such as citalopram hydrobromide (CHB), can mitigate the withdrawal syndrome. However, there are no viable dosage forms on the market to implement the tapering scheme. A solution using a modular design approach to produce flexible and accurate doses of CHB is proposed. This design consists of two parts: (1) a module with a fixed amount of preloaded CHB in a freeze‐dried polymer matrix, and (2) fine‐tuning the CHB dose by inkjet printing. A non‐contact food‐grade printer, used for the first time for printing pharmaceuticals, is modified to allow for accurate printing of the highly concentrated CHB ink on the porous CHB‐free or CHB‐preloaded modules. The produced modules with submicron precision are bench‐marked with commercially available CHB tablets that are manually divided. The proposed tunable modular design (TMD) covers the entire range of doses needed for the tapering (0.5‐23.8 mg). The greatest variance is 13% and 88% when comparing TMD and self‐tapering, respectively. Self‐tapering is proven inaccurate and showcases the need for the TMD to make available accurate and personalized doses to wean off treatment with CHB.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication

Ahola,

Raijada,

Cornett

et al. 2024

Advanced Materials

Self Cite

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Section: Tabletsmentioning

confidence: 99%

Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

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Spatially Variant based on Patch Division for Digital Pill Analysis Using Prototype Model

Nehaa,

Bharathiraja,

Samuel

et al. 2024

2024 5th International Conference on Smart Electronics and Communication (ICOSEC)

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Data-enriched edible pharmaceuticals (DEEPs): Patients' preferences, perceptions, and acceptability of new dosage forms and their digital aspects – An interview study

Cited by 3 publications

References 35 publications

Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication

Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication

Inkjet Printing of Pharmaceuticals

Spatially Variant based on Patch Division for Digital Pill Analysis Using Prototype Model

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