DATA EVALUATION ACQUIRED TALYS 1.0 CODE TO PRODUCE ¹¹¹In FROM VARIOUS ACCELERATOR-BASED REACTIONS

Abstract

The Indium-111 physical-decay parameters as a β-emitter radionuclide show some potential for radiodiagnostic and radiotherapeutic purposes. Medical investigators have shown that 111 In is an important radionuclide for locating and imaging certain tumors, visualization of the lymphatic system and thousands of labeling reactions have been suggested. The TALYS 1.0 code was used here to calculate excitation functions of 112/114–118 Sn+p , 110 Cd +3 He , 109 Ag +3 He , 111–114 Cd+p , 110/111 Cd+d , 109 Ag +α to produce 111 In using low and medium energy accelerators. Calculations were performed up to 200 MeV. Appropriate target thicknesses have been assumed based on energy loss calculations with the SRIM code. Theoretical integral yields for all the latter reactions were calculated. The TALYS 1.0 code predicts that the production of a few curies of 111 In is feasible using a target of isotopically highly enriched 112 Cd and a proton energy between 12 and 25 MeV with a production rate as 248.97 MBq·μA-1 · h-1. Minimum impurities shall be produced during the proton irradiation of an enriched 111 Cd target yielding a production rate for 111 In of 67.52 MBq· μA-1 · h-1.

Production of novel diagnostic radionuclides in small medical cyclotrons

“…Despite being a well-established classical cyclotron produced radionuclide, it can be produced using novel methods employing SMC. From this point of view, only nuclear reaction 111 Cd(p,n) 111 In is feasible (Alipoor, Gholamzadeh, and Sadeghi, 2011 ). It peaks at 15 MeV with approximately 800 mb reaction cross section.…”