The data herein presented concerns the article entitled “Evaluation of hydrochemical properties and groundwater suitability for irrigation uses in southwestern zones of Jashore, Bangladesh”. Data was collected during 2018-2019 in the southwestern zones of Jashore, Bangladesh. One hundred groundwater samples (boreholes and tube wells) were collected to evaluate groundwater quality, using the irrigation water quality index (IWQI) as an indicator. Fourteen hydrochemical parameters (pH, EC, TDS, NO
3
N, pH, EC, Ca
2+
, Mg
2+
, Na
+
, K
+
, Cl
−,
HCO
3
−
, SO
4
2−
and Fe
2+
) were used to calculate irrigation water quality indices (KI, Na%, PI, SAR, SSP, MH, and TH). Statistical methods such as Viper diagrams, USSL, and Wilcox diagrams were used to visualize datasets. The attained data can be used to assess the hydrogeochemistry of the sampled sites and groundwater quality for irrigation purposes. The findings of this work can be used in the optimization of management and treatment procedures and in the implementation of sustainable water development.