Abstract:<div>Abstract<p>Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-cell acute lymphoblastic leukemia (T-ALL). Here, we identify a highly conserved distal enhancer (PE) that interacts with the <i>PTEN</i> promoter in multiple hematopoietic populations, including T cells, and acts as a hub of rel… Show more
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