2023
DOI: 10.1158/0008-5472.c.6510438
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Data from Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8<sup>+</sup> T Cells in Head and Neck Cancer

Abstract: <div>Abstract<p>Human papillomavirus subtype 16 (HPV16) is the primary cause of an increasing number of head and neck squamous cell carcinomas (HNSCC), providing strong rationale for T-cell immune therapies against HPV<sup>+</sup> HNSCC. Here we assess immunogenicity of HPV16-specific CD8<sup>+</sup> T cells (CTL) and characterize HPV-specific mechanisms of T-cell dysfunction. We identified 16 strong and 29 moderately immunogenic CTL-epitopes from HPV16 E2, E6, and E7 antige… Show more

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