Data on Spectroscopic, Rheological characterization of neem oil and its isolated fractions

Bhargava, Samir; Madhav, N. V. Satheesh

doi:10.1016/j.dib.2018.10.049

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…This was supported by two peaks, one at 721 cm -1 due to methylene (-CH 3 ) rocking vibrations and the other at 1159 cm -1 due to C-O-C stretching vibrations of esters. These results were similar to the spectra obtained by Bhargava and Madhav who determined the spectroscopic rheological characterization of NO and its isolated fractions and a corresponding C=O stretching at 1750 cm -1 [39]. Additionally, the spectra of neem oil [40].…”

Section: Ftir Results Of No Additivesupporting

confidence: 89%

Synthesis and Morphology of Flexible Polyurethane Foams Containing Neem Oil and Clove Powder

Kuranchie,

Yaya,

Aboagye-Antwi

et al. 2024

International Journal of Polymer Science

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Polyurethane foams are a versatile class of polymeric materials whose physico-chemical structure and properties can be modified by incorporating additives. This study examined the effect of naturally occurring insect-repelling additives such as neem oil (NO) and clove powder (CP) on the formulation and morphology of flexible polyurethane foam (FPUF) composites. The foams were prepared by the prepolymer method using a box test as applied in the foam industry. The composite material was formulated by varying the isocyanate index (103 and 108) as an excess amount of isocyanate was required to react with the additives. The formulation at 103 was unsuccessful as the foams collapsed immediately after rising. However, at 108, two main categories of foams were successfully prepared: foams containing either NO or CP and the other containing both additives. The effect of these additives on the formulation was examined by monitoring the foam reaction using the cream, tack-free, and rising times. It was observed that the cream, tack-free, and rising times increased with increasing NO/CP content. Conversely, the morphology was studied using scanning electron microscopy (SEM) and optical microscope (OP). The SEM images revealed disruption of the foam network with 1 wt% NO, likewise those containing 1 wt% CP. The cellular network of the foams with simultaneous addition of NO and CP was similar to that of the neat foams and had no broken cell joints and struts due to better dispersion of the additives in the polyurethane matrix. The study indicates that the combined addition of NO and CP modifies the morphology of FPUF, which can influence their physico-mechanical properties.

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Section: Ftir Results Of No Additivesupporting

confidence: 89%

Synthesis and Morphology of Flexible Polyurethane Foams Containing Neem Oil and Clove Powder

Kuranchie,

Yaya,

Aboagye-Antwi

et al. 2024

International Journal of Polymer Science

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“…The main structure of the peaks of the NeO spectrum was also observed in the NeO-SLNs spectrum including C-H aliphatic doublet peak on 2919 and 2852 and C=O doublet peak on 1712 and C-H bending peak on 1456 (Fig. 2 ), which all matched with existing NeO spectra in previous studies [ 38 , 39 ]. Indeed, no specific interaction was observed between the NeO and the lipids used in the formulations.…”

Section: Resultssupporting

confidence: 87%

Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity

Nemati

Rahimi

Hesari

et al. 2022

BMC Complement Med Ther

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Background Toxoplasmosis is caused by an intracellular zoonotic protozoan, Toxoplasma gondii, which could be lethal in immunocompromised patients. This study aimed to synthesize Neem oil-loaded solid lipid nanoparticles (NeO-SLNs) and to evaluate the anti-Toxoplasma activity of this component. Methods The NeO-SLNs were constructed using double emulsification method, and their shape and size distribution were evaluated using transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. An MTT assay was employed to evaluate the cell toxicity of the component. The anti-Toxoplasma activity of NeO-SLNs was investigated using vital (trypan-blue) staining. Anti-intracellular Toxoplasma activity of NeO-SLNs was evaluated in T. gondii-infected Vero cells. Results The TEM analysis represented round shape NeO-SLNs with clear and stable margins. DLS analysis showed a mean particle size 337.6 nm for SLNs, and most of nanoparticles were in range 30 to 120 nm. The cell toxicity of NeO-SLNs was directly correlated with the concentration of the component (P-value = 0.0013). The concentration of NeO-SLNs, which was toxic for at least 50% of alive T. gondii (cytotoxic concentration (CC50)), was > 10 mg/mL. The ability of NeO-SLNs to kill Toxoplasma was concentration-dependent (P-value < 0.0001), and all concentrations killed at least 70% of alive tachyzoites. Furthermore, the viability of T. gondii- infected Vero cells was inversely correlated with NeO-SLNs concentrations (P-value = 0.0317), and in the concentration 100 μg/mL at least 75% of T. gondii- infected Vero cells remained alive. Conclusions Overall, our findings demonstrated that the NeO-SLNs was able to kill T. gondii tachyzoites in concentration 100 μg/mL with a cell toxicity lower than 20%. Such results suggest that employing SLNs as carrier for NeO can effectively kill T. gondii tachyzoites with acceptable cell toxicity. Our findings also showed that SLNs capsulation of the NeO can lead to prolonged release of the extract, suggesting that NeO-SLNs could be also employed to clear cyst stages, which should be further investigated in animal models.

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“…The method used for formation of fatty acid methyl esters was an acid catalyzed method. 6 The fatty acid transformed to its saponified derivative was investigated through GC-MS equipment (Thermo Trace 1300 GC coupled with Thermo TSQ 800 Triple Quadrupole MS; Software -Xcalibur 2.2 SP1). The Investigational conditions for GC-MS system (discussed somewhere else also) 6 are as follows:-Column used -TG 5MS (30 m * 0.25 mm, 0.25 mm; Thermo Fisher Scientific, USA).…”

Section: Preparation Of Fatty Acid Methyl Esters For Gc Analysismentioning

confidence: 99%

Cyclosporine A Loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil

Bhargava¹,

Madhav²

2020

IJPER

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Title: Cyclosporine A loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil. Aim: Nanoemulsions formulation development is an upcoming approach to deliver peptides. The approach reduces challenges during peptide delivery by many folds. Nanoemulsions contains drugs encapsulated or solubilized in an oily phase, with water as continuous phase. In our research, nanoemulsion have been developed for Cyclosporine a using fractions of Sesame oil as encapsulating agent. Methods: The comparison between oil fractions (SOC; SOAM) and Sesame oil have been well proved through Spectral studies like FT-IR, GC-MS and rheology studies. Nanoemulsions have been developed using a modified solvent-evaporation method. FT-IR of oil fraction also shows absence of peaks showing peptide fragments, indicating its encapsulation inside oil fraction. Conclusion: The zeta potential of our selected formulation FSC2 among FSC1-FSC12 has been found to be -15 mV, while its polydispersity is 0.325. The in vitro studies clearly reveals first order release mechanism as best fit model for selected formulation. The r 2 for selected formulation has been identified to be 0.99. The t80 of FSC2 has been found to be 6.5 Hrs. The TEM Studies of formulation reveal spherical appearance of particles with average particle size between 50-220 nm.

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Data on Spectroscopic, Rheological characterization of neem oil and its isolated fractions

Cited by 7 publications

References 8 publications

Synthesis and Morphology of Flexible Polyurethane Foams Containing Neem Oil and Clove Powder

Synthesis and Morphology of Flexible Polyurethane Foams Containing Neem Oil and Clove Powder

Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity

Cyclosporine A Loaded Nanoemulsions using Bio-oil Fractions of Sesame Oil

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