Data on the radioprotective effect of emodin in vivo and vitro via inhibition of apoptosis and modulation of p53

Wang, Jing; Zhang, Yue; Zhu, Qiuzhen; Liu, Yulan; Cheng, Hao; Zhang, Yuefan; Li, Tiejun

doi:10.1016/j.dib.2016.12.038

Cited by 3 publications

(8 citation statements)

References 3 publications

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“…Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone isolated from several Chinese herbs, including Rheum palmatum, Polygonum cuspidatum, and Polygonum multiflorum . Pre-clinical investigations have demonstrated emodin to contain a wide spectrum of pharmacological benefits, including; anti-viral [ 1 ], anti-bacterial [ 2 ], anti-allergic [ 3 ], anti-osteoporotic [ 4 ], anti-diabetic [ 5 , 6 ], anti-inflammatory [ 7 – 10 ], neuroprotective [ 11 ], hepatoprotective [ 12 ], and anti-tumorigenic [ 13 – 18 ] properties (Supplementary Table 1 ). In fact, studies by our group have shown that emodin is effective at reducing mammary tumorigenesis given its actions on macrophages [ 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Safety of natural anthraquinone emodin: an assessment in mice

Sougiannis

Enos

VanderVeen

et al. 2021

BMC Pharmacol Toxicol

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Background Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surrounding its potential toxicity. The primary purpose of this study was to uncover any potential toxic properties of emodin in mice at doses that have been shown to have efficacy in our cancer studies. In addition, we sought to assess the time course of emodin clearance when administered both intraperitoneally (I.P.) and orally (P.O.) in order to begin to establish effective dosing intervals. Methods We performed a subchronic (12 week) toxicity study using 3 different doses of emodin (~ 20 mg/kg, 40 mg/kg, and 80 mg/kg) infused into the AIN-76A diet of male and female C57BL/6 mice (n = 5/group/sex). Body weight and composition were assessed following the 12-week feeding regime. Tissues were harvested and assessed for gross pathological changes and blood was collected for a complete blood count and evaluation of alanine transaminase (ALT), aspartate transaminase (AST) and creatinine. For the pharmacokinetic study, emodin was delivered intraperitoneally I.P. or P.O. at 20 mg/kg or 40 mg/kg doses to male and female mice (n = 4/group/sex/time-point) and circulating levels of emodin were determined at 1, 4 and 12 h following administration via liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis. Results We found that 12 weeks of low (20 mg/kg), medium (40 mg/kg), or high (80 mg/kg) emodin feeding did not cause pathophysiological perturbations in major organs. We also found that glucuronidated emodin peaks at 1 h for both I.P. and P.O. administered emodin and is eliminated by 12 h. Interestingly, female mice appear to metabolize emodin at a faster rate than male mice as evidenced by greater levels of glucuronidated emodin at the 1 h time-point (40 mg/kg for both I.P. and P.O. and 20 mg/kg I.P.) and the 4-h time-point (20 mg/kg I.P.). Conclusions In summary, our studies establish that 1) emodin is safe for use in both male and female mice when given at 20, 40, and 80 mg/kg doses for 12 weeks and 2) sex differences should be considered when establishing dosing intervals for emodin treatment.

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Section: Introductionmentioning

confidence: 99%

Safety of natural anthraquinone emodin: an assessment in mice

Sougiannis

Enos

VanderVeen

et al. 2021

BMC Pharmacol Toxicol

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“…Several natural products with radioprotective abilities have been studied and reported (Table 1) [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17]. The radioprotective mechanism of these natural products has not yet been described in detail, particularly for miRNA modulation.…”

Section: Connection Between Radioprotective Natural Products and Mirnasmentioning

confidence: 99%

“…Since some natural products may exhibit fewer toxic effects than compounds from chemical synthesis, they have become preferable candidates as radioprotectors [2,3]. Recently, several studies have targeted natural bioactive substances as radioprotectors [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17]. However, there is a lack of understanding regarding the mechanisms of action for these radioprotective natural products.…”

Section: Introductionmentioning

confidence: 99%

“…This review focuses on downstream responses for radiation and exosome biogenesis in natural product treatments (Figure 1). Some literature reports have shown that several natural products are radiomodulators [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17], and others offer miRNA modulation for radiation [7, and exosome biogenesis [93,. However, the natural-product-miRNA-downstream axis has two main knowledge gaps regarding the connections between natural products and miRNA regulation and between miRNA and the modulation of radiation and exosome biogenesis (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis

Tang

Chuang

Shiau

et al. 2023

IJMS

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Exosomes are cell-derived membranous structures primarily involved in the delivery of the payload to the recipient cells, and they play central roles in carcinogenesis and metastasis. Radiotherapy is a common cancer treatment that occasionally generates exosomal miRNA-associated modulation to regulate the therapeutic anticancer function and side effects. Combining radiotherapy and natural products may modulate the radioprotective and radiosensitizing responses of non-cancer and cancer cells, but there is a knowledge gap regarding the connection of this combined treatment with exosomal miRNAs and their downstream targets for radiation and exosome biogenesis. This review focuses on radioprotective natural products in terms of their impacts on exosomal miRNAs to target radiation-modulating and exosome biogenesis (secretion and assembly) genes. Several natural products have individually demonstrated radioprotective and miRNA-modulating effects. However, the impact of natural-product-modulated miRNAs on radiation response and exosome biogenesis remains unclear. In this review, by searching through PubMed/Google Scholar, available reports on potential functions that show radioprotection for non-cancer tissues and radiosensitization for cancer among these natural-product-modulated miRNAs were assessed. Next, by accessing the miRNA database (miRDB), the predicted targets of the radiation- and exosome biogenesis-modulating genes from the Gene Ontology database (MGI) were retrieved bioinformatically based on these miRNAs. Moreover, the target-centric analysis showed that several natural products share the same miRNAs and targets to regulate radiation response and exosome biogenesis. As a result, the miRNA–radiomodulation (radioprotection and radiosensitization)–exosome biogenesis axis in regard to natural-product-mediated radiotherapeutic effects is well organized. This review focuses on natural products and their regulating effects on miRNAs to assess the potential impacts of radiomodulation and exosome biogenesis for both the radiosensitization of cancer cells and the radioprotection of non-cancer cells.

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“…At present, emodin is used as a reference drug against Giardia protozoa and it has been a very promising drug. This extract has strong antiinflammatory and antioxidant effects that can be useful in the treatment of osteoporosis, and cardiovascular diseases, CNS, liver, metabolic and respiratory reactions (11,12).…”

Section: Malaria;mentioning

confidence: 99%

Cytotoxicity and Anti-Plasmodium berghei Activity of Emodin Loaded Nanoemulsion

Bayat¹,

Haghi²,

Nateghpour³

et al. 2022

IJPA

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Background: Malaria parasites cause a tremendous burden of disease in both the tropics and subtropics areas. Growing of drugs resistance in parasites is one of the most threats to malaria control. The aim of study was to investigate the anti-malarial activity of nano-emodin isolated from Rhamnus cathartica on Plasmodium berghei in mice to evaluate parasites inhibition rate using in-vivo test. Methods: The study was conducted in the School of Public Health, Tehran University of Medical Sciences, during 2020. Nano- emodin particles were prepared from Rhamnus cathartica, and confirmed by Zeta Potential Analyzer, DLS and electron microscopy techniques. Mice were infected with P. berghei and treated by emodin nanoparticles. Parasitemia was evaluated in each group in comparison with control group. Toxicity test was done using twice the highest concentration of emodin extract on a separate group of mice and ED50 was calculated. Results: Emodin extract was significantly effective in all concentrations on D4 (P<0.05). The most effective on parasitemia was observed in 400 mg/kg of Liquid Nano-emodin and solid (non-Nano) emodin. ED50 for emodin extract was determined 220 mg/kg. Toxicity test showed no toxic effect on the subjects. Conclusion: The emodin extract is safe, lack of side effects. So, it can be used for more and longer period of time and in higher doses. Emodin extract, either in form of liquid and nanoparticle or in a solid form, has the same therapeutic effect on P. berghei in infected Balb/c mice.

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Data on the radioprotective effect of emodin in vivo and vitro via inhibition of apoptosis and modulation of p53

Cited by 3 publications

References 3 publications

Safety of natural anthraquinone emodin: an assessment in mice

Safety of natural anthraquinone emodin: an assessment in mice

Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis

Cytotoxicity and Anti-Plasmodium berghei Activity of Emodin Loaded Nanoemulsion

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