Data science to analyse the largest natural experiment of our time

Dee, Edward Christopher; Paguio, Joseph Alexander; Yao, Jasper Seth; Stupple, Aaron; Celi, Leo Anthony

doi:10.1136/bmjhci-2020-100177

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…25 Data scientists may help define patterns of success and failure among various interventions. 26 Policymakers, particularly at the local level, may influence local actions and decisions among citizens in their jurisdictions. 5,27 The private sector -mavericks in supply chain and logistics managementmay understand the macroscopic supply and demand factors at play, and could aid policymakers in program implementation.…”

Section: Lessons and Considerations For Covid-19mentioning

confidence: 99%

Vaccination in the Philippines: experiences from history and lessons for the future

Reyes

Dee

Ho³

2020

Human Vaccines & Immunotherapeutics

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In anticipation of a potential vaccine for COVID-19, vaccine uptake may be critical in overcoming the pandemic, especially in countries like the Philippines, which has among the highest rates of infection in the region. Looking at the progress of vaccination in the country -its promises, pitfalls, and challengesmay provide insight for public health professionals and the public. The history of vaccination in the Philippines is marked by strong achievements, such as the establishment and growth of a national programme for immunization, and importantly, the eradication of poliomyelitis and maternal and neonatal tetanus. It is also marred by critical challenges which provide a springboard for improvement across all sectors -vaccine stock-outs, strong opposition from certain advocacy groups, and the widely publicized Dengvaxia controversy. Moving forward, with recent surveys having shown that vaccine confidence has begun to improve, these experiences may inform the approaches taken to address vaccine uptake. These lessons from the past highlight the importance of a strong partnership between health leaders and the local community, bearing in mind cultural appropriateness and humility; the engagement of multidisciplinary stakeholders; and the importance of foresight in preparing public health infrastructure for the arrival of a COVID-19 vaccine.

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Section: Lessons and Considerations For Covid-19mentioning

confidence: 99%

Vaccination in the Philippines: experiences from history and lessons for the future

Reyes

Dee

Ho³

2020

Human Vaccines & Immunotherapeutics

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“…Although our findings are based on retrospective data, thoughtful and thorough analyses of such data in light of the urgency of the ongoing pandemic will likely continue to play a valuable role in paving the way forward. 6 We recognize that prospective randomized controlled trials remain the gold standard of clinical studies. However, situations in which randomized trials are too costly, too slow, or not feasible may necessitate taking into consideration causal inference studies such as ours in informing clinical decisions.…”

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confidence: 99%

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Paguio

Dee

et al. 2021

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Exercise and Experiments of Nature

Joyner

Wiggins

Baker

et al. 2023

Comprehensive Physiology

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In this article, we highlight the contributions of passive experiments that address important exerciserelated questions in integrative physiology and medicine. Passive experiments differ from active experiments in that passive experiments involve limited or no active intervention to generate observations and test hypotheses. Experiments of nature and natural experiments are two types of passive experiments. Experiments of nature include research participants with rare genetic or acquired conditions that facilitate exploration of specific physiological mechanisms. In this way, experiments of nature are parallel to classical "knockout" animal models among human research participants. Natural experiments are gleaned from data sets that allow population-based questions to be addressed. An advantage of both types of passive experiments is that more extreme and/or prolonged exposures to physiological and behavioral stimuli are possible in humans. In this article, we discuss a number of key passive experiments that have generated foundational medical knowledge or mechanistic physiological insights related to exercise. Both natural experiments and experiments of nature will be essential to generate and test hypotheses about the limits of human adaptability to stressors like exercise.

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Data science to analyse the largest natural experiment of our time

Cited by 3 publications

References 16 publications

Vaccination in the Philippines: experiences from history and lessons for the future

Vaccination in the Philippines: experiences from history and lessons for the future

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Exercise and Experiments of Nature

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