Dataset on genetic and physiological adults׳ responses to social distress

Bonassi, Andrea; Ghilardi, Tommaso; Truzzi, Anna; Cataldo, Ilaria; Azhari, Atiqah; Setoh, Peipei; Shinohara, Kazuyuki; Esposito, Gianluca

doi:10.1016/j.dib.2017.06.057

Cited by 9 publications

(10 citation statements)

References 18 publications

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“…This study adopted the same DNA derivation and genotyping procedure used by Bonassi and colleagues [ 43 ], using ACGT, Inc. (Wheeling, IL). DNA was extracted from each kit using the Oragene DNA purifying reagent, then concentrations were assessed through spectroscopy (NanoDrop Technologies, USA).…”

Section: Methodsmentioning

confidence: 99%

Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships

et al. 2021

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Early interactions with significant individuals affect social experience throughout the course of a lifetime, as a repeated and prolonged perception of different levels of care, independence, or control influences the modulation of emotional regulatory processes. As many factors play a role in shaping the expectations and features of social interaction, in this study, we considered the influence of parental bonding and genetic allelic variation of oxytocin receptor gene polymorphism (rs53576) over levels of experienced anxiety and avoidance in 313 young adults belonging to two different cultural contexts, namely Italy and Singapore. Results highlighted a major effect of maternal characteristics, care, and overprotection, with differences between the two cultural groups. Additionally, the interaction between rs53576 and maternal overprotection suggested different environmental susceptibility in the Italian sample and the Singaporean one. Implications for clinical work and future steps are described in the Conclusion.

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Section: Methodsmentioning

confidence: 99%

Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships

et al. 2021

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“…The same data extraction procedure used by Bonassi et al [ 71 ] was adopted in this study. Specifically, DNA derivation and genotyping were executed by ACGT, Inc. (Wheeling, IL, USA).…”

Section: Materials and Methodsmentioning

confidence: 99%

Oxytocin Receptor Gene Polymorphisms and Early Parental Bonding Interact in Shaping Instagram Social Behavior

Bonassi

Cataldo

Gabrieli

et al. 2020

IJERPH

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Human beings engage in multiple social interactions daily, both in person and online. There are, however, individual differences in the frequency and quality of these interactions. This exploratory study focuses on online interactions and aims to model these differences by looking at potential environmental and genetic factors. The environmental factor is the childhood parental relationship, as reported by the participants in the dimensions of the Parental Bonding Instrument (N = 57, 41 females). At a genetic level, buccal mucosa cell samples were collected to assess participants’ genetic susceptibility, and OXTr regions rs2254298 (G/G homozygotes vs. A-carriers) and rs53576 (A/A homozygotes vs. G-carriers) were analyzed. To capture participants’ online activity, Instagram was probed. The number of people that the individual follows (“followings”), followers, and posts were used as a proxy for the quantity of interaction, and a Social Desirability Index (SDI) was computed as the ratio of followers to followings. An interaction between OXTr groups and parental bonding scores on the number of followings and posts was hypothesized. A gene-environment interaction for OXTr/rs2254298 on the number of Instagram posts was identified. In line with the hypothesis, participants with a genetic risk factor (A-carriers) and a history of low paternal care showed fewer Instagram posts than those without this risk factor (G/G genotype). Moreover, an interaction effect between maternal overprotection and OXTr/rs2254298 on the Instagram SDI was detected. These findings could represent an indirect pathway through which genes and parental behavior interact to shape social interactions on Instagram.

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“…The same DNA sequencing technique adopted by Bonassi and colleagues [28] was used in this study. DNA extraction and genotyping were performed by ACGT, Inc. (Wheeling, IL) for the 5-HTT gene (SLC6A4) rs25531 region target.…”

Section: Genotypingmentioning

confidence: 99%

The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

Bonassi¹,

Cataldo²,

Gabrieli³

et al. 2020

Preprint

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Human social interactions ensure recognition and approval from others, both in offline and online environments. This study applies a model from behavioural genetics on Instagram sociability to explore the impact of individual development on the behaviour on social networks. We hypothesize that sociable attitudes on Instagram resulted from an interaction between serotonin transporter gene alleles and the individual's social relationship with caregivers. We assess environmental and genetic components of 57 Instagram users. The self-report questionnaire Parental Bonding Instrument is adopted to determine the quality of parental bonding. The number of posts, followed users ("followings"), and followers are collected from Instagram as measures of online social activity. Additionally, the ratio between the number of followers and followings ("Social Desirability Index") was calculated to estimate the asymmetry of each user's social network. Finally, buccal mucosa cell samples were acquired, and the polymorphism rs25531 (T/T homozygotes vs C-carriers) within the serotonin transporter gene was examined. In the preliminary analysis, we identified a gender effect on the number of followings. In the main analysis, an effect of paternal care was also detected on the same variable. In line with our predictions, we specifically found a gene-environment interaction on the standardized Instagram "Social Desirability Index": users with the genotype more sensitive to environmental influences (T/T homozygotes) showed a higher Instagram "Social Desirability Index" than non-sensitive ones (C-carriers) when they experienced positive maternal care. This result may contribute to the understanding of online social behaviour from a gene*environment perspective.

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Dataset on genetic and physiological adults׳ responses to social distress

Cited by 9 publications

References 18 publications

Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships

Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships

Oxytocin Receptor Gene Polymorphisms and Early Parental Bonding Interact in Shaping Instagram Social Behavior

The interaction between serotonin transporter allelic variation and maternal care modulates sociability on Instagram

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